Thrombogenicity of heparin- and non-heparin-coated catheters: clinical trail

Abstract

Prese nted at the annual meeting o f the American Soc iety o f Neuroradio log y, Chica90, Apri l 198 1.

Antithrombogenic Heparin-Bound Polyurethanes

“…'Ib reduce the release rate of heparin, a heparinized surface is sometimes treated with glutaraldehyde to fix the heparin on the surface [28]. The materials heparinized by these methods are widely applied in clinical use [29]. There are other methods to immobilize heparin on plastic surfaces.…”

A scanning electron microscopic study on thrombogenicity of intraarterial catheters for chemotherapeutic treatment in head and neck cancer

“…21À23,41 Many studies have been published on thrombogenic properties of vascular catheter materials both in vitro and in vivo. 16,17,19,42 Most investigators found that endovascular devices manufactured from polyethylene were superior to those made of polyurethane in terms of surface quality and debris accumulation. 19,43,44 The effects of surface roughness of plastic devices on thrombogenicity have been emphasized.…”

“…Both inner and outer surfaces are potentially inactivated. 25,26,30,42 An in vitro study by Engbers et al 16 reported that with polyurethane catheters, the adhesion of platelets on the catheter surface is mainly determined by the rate of reaction between platelets and the material surface. Heparin-coated catheters showed a fourfold to fivefold reduction in platelet adhesion compared with uncoated catheters.…”

“…54 Also, release of heparin from antithrombotic coatings might contribute to a time-dependent increase of thrombogenesis on pulmonary catheters, cardiopulmonary bypasses, and cerebral angiographic devices. 27,42,55 Although significant progress has been made in the design of blood-compatible polymers in the past decade, there is no ideal polymer surface that is comparable to a natural endothelial surface in preventing surface-induced thrombosis and maintaining hemostasis. Several surface modification techniques are currently being used to improve the biocompatibility of blood-contacting devices.…”

Staphylococcal adherence to polyvinyl chloride and heparin-bonded polyurethane catheters is species dependent and enhanced by fibronectin

“…Although many factors are thought to contribute to the high incidence of sepsis in newborn infants with indwelling catheters, the effect of catheter composition on the adherence of microorganisms has received little attention (18,21,22). The recently introduced heparinbonded polyurethane (HBP) catheters are purported to decrease the incidence of thrombosis (13). Heparin, however, may also provide a substrate for factors in serum, such as fibronectin (FN), which can modulate bacterial adherence.…”