Thrombolysis Potential of Methanol Extracts from the Five Medicinal Plants Leaf, Available in Bangladesh

Jakaria, Md.; Islam, Md. Ashikul; I, Md. Shariful; Talu, Mohammad Belal; Clint, Chayan Dhar; Ibrahim, Mohammed

doi:10.5567/pharmacologia.2017.78.82

Cited by 5 publications

(2 citation statements)

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“…The thrombolytic activity of AMFV was evaluated following the clot lysis test [21][22][23] In in vivo animal experiment, twenty-four animals were divided into four groups where each group consists of six animals (n=6). The standard drug diclofenac sodium (10 mg/kg, b.w, i.p.)…”

Section: Thrombolytic Activitymentioning

confidence: 99%

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

et al. 2021

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Merremia vitifolia (Burm.f.) Hallier f., an ethnomedicinally important plant, used in the tribal areas to treat various ailments including fever, headache, eye inflammation, rheumatism, dysentery, jaundice and urinary diseases. The present study explored the biological efficacy of the aqueous fraction of M. vitifolia leaves (AFMV) through in vitro and in vivo experimental models. The thrombolytic and anti-arthritic effects of AFMV were evaluated by using the clot lysis technique and inhibition of protein denaturation technique, respectively. The anti-nociceptive activity of AFMV was investigated in Swiss Albino mice by acetic acid-induced writhing test and formalin-induced paw licking test. The antioxidant activities of AFMV, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and total reducing power, were also tested. The qualitative phytochemical assays exhibited AFMV contains secondary metabolites such as alkaloid, carbohydrate, flavonoid, tannin, triterpenoids and phenols. In addition, AFMV showed strong antioxidant effects with the highest scavenging activity (IC50 146.61 µg/mL) and reducing power was increased with a dose-dependent manner. AFMV also revealed notable clot lysis effect and substantial anti-arthritic activity at higher doses (500 µg/mL) as compared with the control. The results demonstrated a promising reduction of the number of writhing and duration of paw licking in acetic acid-induced writhing test and formalin-induced paw licking test in a dose-dependent manner, respectively. In conclusion, AFMV provides the scientific basis of its folkloric usage, suggesting it as the vital source of dietary supplement.

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Section: Thrombolytic Activitymentioning

confidence: 99%

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

et al. 2021

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“…Though alteplase, anistreplase, streptokinase, urokinase and tissue plasminogen activator are wonderful clot lysis agents but still they have significant paucity, including the need for large doses, limited fibrin specificity, bleeding tendency, allergic reactions, and in some cases the thrombi have been proven to be resistant to intravenous tissue plasminogen activator (t-PA) (Bhaargavi and Sindhuja, 2016). For that reason, recently researches are emphasized on traditional and herbal drugs as effective alternatives and numbers of plants have already been indicated to show very outgoing and influential thrombolytic agents (Jakaria et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Methanol soluble fraction of fruits of Annona muricata possesses significant antidiarrheal activities

Afroz

Hoq

Jahan

et al. 2020

Heliyon

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Medicinal plants are the major sources of traditional treatment of disease in Indian subcontinent due to abundant presence of plants and vast side effects of synthetic drug. The present study was subjected to observe in vitro thrombolytic, antibacterial, and in vivo antidiarrheal activities of methanol soluble fraction of fruits of Annona muricata. In thrombolytic activity assay, various concentrations (2 ─ 10 mg/ml) of methanol soluble fraction was used and dose dependently less potent activity was found. The maximum clot lysis 18.33% (p* < 0.05) was achieved at 10 mg/ml of methanolic fruit extract, whereas standard drug streptokinase showed 55.50% (p*** < 0.001) clot lysis. In antibacterial assay, disc diffusion method was used comprising two gram positive (S. aureus and Micrococcus luteus) and two gram negative (E. coli and P. aeruginosa) bacteria. None of four (0.25, 0.5, 1, and 5 mg/disc) concentration of fruit extract showed antibacterial potentiality, whereas standard amikacin (3 mg/disc) revealed strong antibacterial activities (=~ 23 ─ 24 mm of MIC). To evaluate antidiarrheal activity, castor oil induced diarrhea was created in Swiss albino mice and different doses (100, 200, and 400 mg/kgbw) of fruit extract was introduced post orally. All of three different doses of fruit extract showed significant (p < 0.05 ─ 0.001) antidiarrheal activities. Notably, the percent inhibition of diarrhea by methanolic extract of fruits of Annona muricata was found to be 58.38% at a dose of 400 mg/kgbw. The effect of vehicle saline (10 ml/kgbw) was considered as control and loperamide (5 mg/kgbw) as standard that provided 67.01% inhibition of diarrhea. The results suggest that, the fruits of Annona muricata possess potent antidiarrheal properties, providing scientific basis of using the plant parts in the treatment of diarrheal disease.

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An integrated medicine of Bhutan: Sowa Rigpa concepts, botanical identification, and the recorded phytochemical and pharmacological properties of the eastern Himalayan medicinal plants

Yeshi

Gyal

Sabernig

et al. 2019

European Journal of Integrative Medicine

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Thrombolysis Potential of Methanol Extracts from the Five Medicinal Plants Leaf, Available in Bangladesh

Cited by 5 publications

References 0 publications

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

Methanol soluble fraction of fruits of Annona muricata possesses significant antidiarrheal activities

An integrated medicine of Bhutan: Sowa Rigpa concepts, botanical identification, and the recorded phytochemical and pharmacological properties of the eastern Himalayan medicinal plants

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