Thrombophilia and early pregnancy loss

McNamee, K; Dawood, Feroza; Farquharson, Roy G.

doi:10.1016/j.bpobgyn.2011.10.002

Cited by 53 publications

(39 citation statements)

References 89 publications

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“…Disparities exist not only in the diagnostic workup but also in standards of laboratory methods used to investigate acquired and inherited thrombophilia [13].…”

Section: Leading Article Investigating For Haematological Causes Of Rmentioning

confidence: 99%

Recurrent pregnancy loss and thrombophilia

Motha

Palihawadana

Perry³

2014

Ceylon Med. J.

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“…Disparities exist not only in the diagnostic workup but also in standards of laboratory methods used to investigate acquired and inherited thrombophilia [13].…”

Section: Leading Article Investigating For Haematological Causes Of Rmentioning

confidence: 99%

Recurrent pregnancy loss and thrombophilia

Motha

Palihawadana

Perry³

2014

Ceylon Med. J.

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“…The authors conclude that by the current state of evidence, testing for inherited thrombophilia should not lead to altered clinical management and so, should not be performed routinely in women with recurrent miscarriage. In light of the available data, a well-designed, multi-center collaboration is required to ascertain the effect of inherited thrombophilia on early pregnancy loss and to establish evidence-based treatment recommendations [44].…”

Section: Genetics and Treatment Of Reproductive Adversity In Thrombopmentioning

confidence: 99%

Pharmacogenetics and the Treatment of Thrombophilia

Novaković¹,

Maksimović²,

Cvetković³

2013

Pregnancy Thrombophilia - The Unsuspected Risk

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“…Thrombophilia refers to a group of inherited or acquired coagulation disorders leading to venous and/ or arterial thrombosis as well as reproductive disorders such as fetal loss (FL) (1)(2)(3). The most frequent genetic risk factors associated with thrombo philia include factor V Leiden (G1691A), pro throm bin G20210A and PAI-1 4G/5G gene variants (1).…”

Section: Introductionmentioning

confidence: 99%

“…The most frequent genetic risk factors associated with thrombo philia include factor V Leiden (G1691A), pro throm bin G20210A and PAI-1 4G/5G gene variants (1).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Pai-1 4g/5g Polymorphism in Women With Fetal Loss – First Data for a Serbian Population / Učestalost Polimorfizma Pai-1 4g/5g Kod Žena Sa Spontanim Pobačajem - Prvi Podaci Za Srpsku Populaciju

Đorđević¹,

Gvozdenov²,

Pruner³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis. The PAI-1 4G/5G polymorphism is associated with elevated plasma levels of PAI-1. Overexpression of PAI-1 and impaired fibrinolysis in homozygous carriers of the 4G/4G PAI polymorphism may lead to abnormal placental formation and increased risk of fetal loss (FL). The aim of our study was to determine the frequency of this polymorphism in patients with FL in a Serbian population. Methods: The study was carried out in a group of 203 women (91 controls and 112 women with FL). The presence of PAI-1 4G/5G polymorphism was detected by PCR-RFLP analysis. Results: Slightly increased frequency of the PAI-1 4G/4G genotype was observed in the study group compared to the controls (32.1% vs. 30.8%). The frequency of PAI-1 was highest in women experiencing FL in the second trimester of pregnancy (50%), but this difference was not statistically significant. Conclusions: Our findings suggest that PAI-1 4G/4G might be a risk factor for FL occurring in the second trimester of pregnancy. Further studies are required in order to determine the role of PAI-1 4G/5G polymorphism in the etiology of FL.

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Thrombophilia and early pregnancy loss

Cited by 53 publications

References 89 publications

Recurrent pregnancy loss and thrombophilia

Recurrent pregnancy loss and thrombophilia

Pharmacogenetics and the Treatment of Thrombophilia

The Prevalence of Pai-1 4g/5g Polymorphism in Women With Fetal Loss – First Data for a Serbian Population / Učestalost Polimorfizma Pai-1 4g/5g Kod Žena Sa Spontanim Pobačajem - Prvi Podaci Za Srpsku Populaciju

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