The cause of recurrent miscarriage is multifactorial and appropriate treatment continues to be a challenge. Laboratory tests need to be standardized and well designed multicentre research trials are essential to expand on the current knowledge base with the aim to produce strong evidence-based medicine.

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Chromosomal analysis of a failed pregnancy following the diagnosis of recurrent miscarriage is not standard practice yet an abnormal karyotype is one of the commonest causes. Array comparative genomic hybridization heralds a new and improved era of cytogenetics, which may prevent unnecessary interventions for patients.

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