Thrombophilic Mutations in Iran

Prevalence of factor V Leiden (G1691A) and prothrombin (G20210A) among Kurdish population from Western Iran

“…The prevalence of prothrombin G20210A mutation in the present study was 1.6%, with allele frequency of 0.8%, which again, is lower than that found (3.1%, allele frequency of 1.5%) in Tehran population [10]. The prothrombin G20210A mutation is rarely seen in Asian populations [8].…”

“…The reasons for different prevalence of this thrombophilic mutation in our study, compared to Zeinali et al report [10], could be attributed to differences in sample sizes, differences in ethnic backgrounds and selection of the populations studied. Further, the allele frequency of factor V leiden mutation in our population is lower than some neighboring countries, including Turkey (4.5-4.9%) [14].…”

“…Previously, Zeinali et al [10] had reported an allele frequency of 2.7% for factor V Leiden mutation and an allele frequency of 1.5% for prothrombin G20210A mutation among 161 healthy Iranian individuals from Tehran, the capital. We aimed to assess the prevalence of these thrombophilic mutations in 434 healthy individuals from a distinct Iranian ethnic group, Kurds, living in the Kermanshah Province of Iran and to find the possible influence of ethnicity on the prevalence of factor V Leiden and prothrombin G20210A mutations in this population.…”

Thrombophilic mutations among Southern Iranian patients with sickle cell disease: high prevalence of factor V Leiden

“…Furthermore, Otrock et al [5] found that the concomitant presence of homozygosity for FV Leiden and heterozygosity for the methylenetetrahydrofolate reductase (MTHFR) mutation in a sickle-beta zero thalassemia patient led to the development of extensive deep vein thrombosis. A relatively high frequency of factor V Leiden mutation and a moderate frequency of prothrombin G20210A has been reported in Iranians [15]. Recently we studied 434 individuals from Western Iran and found a prevalence of 1.6% and 2.97% for prothrombin gene mutation and factor V Leiden, respectively (J Thromb Thrombolys, accepted for publication), which are lower than those from the prevalence of 5.5% for factor V Leiden and 3.1% for prothrombin mutation reported by Zeinali et al [15] in 161 subjects from Tehran, a city with mixed ethnicity.…”

Factor V Leiden in Blood Donors in Baghdad (Iraq)

“…The prevalence rate of 3% in Iraqi blood donors, although it is much lower than the prevalence rates of 14.2%, 13.6%, and 12.25% reported in Lebanon, Syria, and Jordan, respectively (4,7 ), and to a lesser extent than the rates in Turkey (7.4%) (8 ) and Iran (5.5%) (9 ), is comparable to the prevalence of 2.5% reported in Clinical Chemistry 50, No. 3, 2004 Saudi Arabia (10 ).…”