Thrombopoietin and mean platelet volume in coronary artery disease

Abstract

SummaryBnckgmund: Large platelets are shown to be hemostatically more active. It has been suggested that mean platelet volume (MPV) is increased during acute myocardial infarction (AMI) and unstable angina pectoris (USAP). However, the underlying mechanism of the phenomenon remains unclear.Hypothesis: In this study, platelets, MPV, and thrombopoietin (TP) levels were investigated in patients with coronary artery disease (CAD) and healthy controls.Methods: Twenty patients with AM1 and 20 patients with USAP were included in this study. Seventeen healthy adult subjects served as controls. Venous blood samples of the subjects were drawn within 12 h after admission. Thrombopoietin levels were measured by ELISA and platelet counts and MPV were assayed by autoanalyzer.Results: Patients with AM1 and USAP had higher platelet counts than those in the control group. Although the platelet counts were slightly higher in AM1 than in USAP, this did not reach statistical significance. Mean platelet volume and levels of TP were found to be elevated in patients with AM1 and USAP compared with control subjects (p<O.OOl). Thrombopoietin levels were higher in AM1 than USAF' , but this was not statistically significant. There was a positive correlation between TP levels and MPV values (p < 0.05).Conclusion: Increased TP levels may increase both platelet counts and platelet size, resulting in hemostatically more active platelets, which may contribute to the development and progression of CAD.

Mean platelet volume and its prognostic value in acute coronary syndrome complicated by cardiogenic shock

“…It also stimulates alpha granule secretion from platelets and enhances their ability to aggregate [10]. TPO was positively correlated with MPV in ACS patients in the report of Senaran et al [11].…”

Increased mean platelet volume in type 2 diabetes mellitus

“…Mean platelet volume has been studied in many vascular diseases. Platelets play a pivotal role in atherothrombosis, the major cause of most unstable coronary syndromes and increased MPV levels have been shown as an indicator in myocardial infarcts [4,[11][12][13], congestive heart disease [13], cerebrovascular diseases [14], obesity [15] and hypertensive patients [16,17]. There is a previous study that suggested a relationship between high MPV levels and an increase in the frequency of restenosis in patients who received coronary angioplasty [18].…”

Can Blood Groups, Neutrophil-Lymphocyte Ratio and Mean Platelet Volume Predict Mortality in Critically Ill Patients Developing Acute Kidney Injury?

“…Large platelets can be defined as stressplatelets. MPV is increased when there is increased destruction of peripheral platelets, and is decreased when there is impairment of platelet production [13]. Since larger platelets are more reactive, MPV is regarded as an indicator of increased cardiovascular disease risk in the general population.…”