Thrombosis in Systemic Lupus Erythematosus: Role of Impaired Fibrinolysis

Dhillon, Parvinderjit K.; Adams, Murray J.

doi:10.1055/s-0033-1334484

Cited by 33 publications

(32 citation statements)

References 53 publications

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“…Among atypical clinical features at presentation, four (6.6%) patients presented with unilateral deep vein thrombosis and would have impaired fibrinolysis 19. Three (4.9%) patients had vasculitic infarcts and gangrene.…”

Section: Discussionmentioning

confidence: 99%

Pattern of initial clinical manifestations of systemic lupus erythematosus in a tertiary care hospital

Batool¹,

Ahmad²,

Saeed³

et al. 2016

Pak J Med Sci

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Objective:To determine the pattern of initial clinical manifestations of Systemic Lupus Erythematosus (SLE) and to compare these features with those recorded elsewhere in PakistanMethods:This cross-sectional, descriptive study was performed in the Department of Rheumatology, Fatima Memorial Hospital, Lahore, Pakistan, from November 2015 to January 2016. Sixty one patients of SLE diagnosed as per ACR (American College of Rheumatology) 1982 revised criteria, were enrolled. The patients were evaluated for the initial clinical manifestations of SLE. The information was collected on a specially designed proforma and analyzed by using SPSS version 17.Results:Out of 61 patients, 49 (80.3%) were females and 12 (19.7%) males, showing a female to male ratio of 4:1. The mean age of patients was 26.2 ± 7.9 years. Fatigue was the most common presenting feature in 56 (91.8%) patients, followed by joint pains in 55 (90.2%) and fever in 54 (88.5%). Renal involvement was found in 46 (75.4%). Comparison of these presenting features was made with other studies carried out in Northern Pakistan (Islamabad) and in central Punjab (Pakistan). There were statistically significant differences in fever, fatigue and arthritis between our patients and the other two above mentioned study groups. However, comparison of renal manifestations showed significant difference only with Islamabad study, and not with previous study from central Punjab.Conclusion:In this study, majority of patients presented with combination of fatigue, fever, rash and arthritis. Almost three-fourth of patients had renal manifestations at initial presentation. Therefore, it is important for clinicians to have high index of suspicion for SLE, when patients present with above symptoms.

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Section: Discussionmentioning

confidence: 99%

Pattern of initial clinical manifestations of systemic lupus erythematosus in a tertiary care hospital

Batool¹,

Ahmad²,

Saeed³

et al. 2016

Pak J Med Sci

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“…Different mechanisms have been described as aetiological agents of impaired fibrinolysis in SLE and APS patients. Some are not related to aPL, such as the increased plasminogen activator inhibitor type 1 (PAI-1) activity that may inhibit tissue plasminogen activator (tPA) activity, while others are related to aPL such β2GPI antibodies, which interferes with the interaction of β2GPI with tPA activator and the enhancement of tPA activity [224].…”

Section: Impaired Fibrinolysismentioning

confidence: 99%

The diagnosis and management of the haematologic manifestations of lupus

Velo-García

Castro

Isenberg

2016

Journal of Autoimmunity

122

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Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe. Therefore, different treatment approaches are needed from simply keeping vigilant to significant immunosuppression. Most treatment evidence is based on case-reports or small retrospective studies, as few randomized controlled trials have been performed. The development of biological therapy has opened new possible ways to treat the most severe cases but further clinical trials are necessary. In this review we consider the most common and characteristic haematological manifestations of SLE patients, focusing on their pathogenesis and management.

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“…Impaired fibrinolysis has been reported in patients with SLE and may contribute to both the development of hypercoagulability and an increased risk of thrombosis [98].…”

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confidence: 99%