Thrombosis of the Mesenteric Vein as a Complication of Mediterranean Spotted Fever

Gangrene is an uncommon complication in cases of rickettsial spotted fever. We report three cases of spotted fever from south India, presumably caused by Rickettsia conorii subspecies indica. Along with gangrene, these cases had severe manifestations of sepsis and multiorgan dysfunction syndrome (MODS) like acute kidney injury, liver dysfunction, delirium and seizure. One patient died while the other two recovered well. This case series is being reported to highlight the occurrence of gangrene in spotted fever rickettsiosis and the importance of appropriate management at the earliest.

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“…Other serious complications of rickettsial infections include thrombosis of major blood vessels, 12 severe sepsis syndrome and death.…”

Section: Discussionmentioning

confidence: 99%

Gangrene in cases of spotted fever: a report of three cases

et al. 2012

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“…Patients with malignant forms have a petechial rash and neurological, renal, or cardiac problems, especially elderly people (206). Thrombosis of the deep venous vessels and acute pericarditis have also been described as complications of boutonneuse fever (70,145). Variations in the severity of MSF have been encountered in different countries and even in different areas of the same country.…”

Section: Previously Described Diseasesmentioning

confidence: 99%

Rickettsioses as paradigms of new or emerging infectious diseases

1997

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Rickettsioses are caused by species of Rickettsia, a genus comprising organisms characterized by their strictly intracellular location and their association with arthropods. Rickettsia species are difficult to cultivate in vitro and exhibit strong serological cross-reactions with each other. These technical difficulties long prohibited a detailed study of the rickettsiae, and it is only following the recent introduction of novel laboratory methods that progress in this field has been possible. In this review, we discuss the impact that these practical innovations have had on the study of rickettsiae. Prior to 1986, only eight rickettsioses were clinically recognized; however, in the last 10 years, an additional six have been discovered. We describe the different steps that resulted in the description of each new rickettsiosis and discuss the influence of factors as diverse as physicians' curiosity and the adoption of molecular biology-based identification in helping to recognize these new infections. We also assess the pathogenic potential of rickettsial strains that to date have been associated only with arthropods, and we discuss diseases of unknown etiology that may be rickettsioses.

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“…3 Landau describes a case of mesenteric vein thrombosis as a complication of MSF. 9 Beselga et al publish a case of retinal artery occlusion in the context of MSF. 5 Ben Brahim et al give a case of pulmonary thrombosis as a complication of MSF.…”

Section: Discussionmentioning

confidence: 99%

Rickettsia conorii: Unusual case of acute aortic thrombosis

2022

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Objectives Mediterranean spotted fever is a common zoonosis in Europe caused by Rickettsia conorii bacterium . Among its wide range of clinical presentations, arterial thrombosis of large vessels has never been described before. Methods We report a case of a complete acute infrarenal aortic thrombosis in a 61-year-old male with R. conorii infection . Results and Conclusion The patient was successfully operated using open aortic surgery and subsequent treatment with doxycycline. To our knowledge, this is the first report of aortic thrombosis associated with infection by this parasite, extending the clinical spectrum of the disease.

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Thrombosis of the Mesenteric Vein as a Complication of Mediterranean Spotted Fever

Cited by 8 publications

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Gangrene in cases of spotted fever: a report of three cases

Gangrene in cases of spotted fever: a report of three cases

Rickettsioses as paradigms of new or emerging infectious diseases

Rickettsia conorii: Unusual case of acute aortic thrombosis

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