Thrombosis of the Posterior Inferior Cerebellar Artery Secondary to Nephrotic Syndrome

Gauna, Ramón Ruiz de; Alcelay, L. Galdós; Conesa, Maria J. Soto; Asarta, Arantza Pinedo

doi:10.1159/000188828

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Few studies have suggested that hyper coagulability in NS is associated with the steroid and diuretic administration [9]. Although there are case reports of NS and stroke [7,[10][11][12][13][14][15][16], we report this case to illustrate the importance of considering hypercoagulability from NS as a potential cause of embolic stroke, and to initiate anticoagulation treatment if appropriate. Additionally, we performed an extensive literature search for NS and association with ischemic stroke.…”

Section: Introductionmentioning

confidence: 85%

Embolic Stroke and Nephrotic Syndrome: A Case Report and Literature Review

Androulakis

2017

OAJNN

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Nephrotic syndrome (NS) is less commonly associated with arterial thrombosis than venous thrombosis. We report a case of a 43-yearoldwomanwho presented with an acute embolic stroke confirmed on MRI, about 3 months after the diagnosis of NS. The standard stroke evaluations did not show evidence ofcardiac source of embolism, large vessel atherosclerosis or any primary hypercoagulable disorders. Laboratory tests revealed impaired renal function and extremely high nephrotic range proteinuria and a renal biopsy showed primary membranous glomerulonephropathy. Subsequently, she was discharged on anticoagulation and responded well to the treatment. This case illustrates the importance of considering hypercoagulable evaluation due to nephrotic syndrome as a potential cause of embolic stroke, and the initiation of anticoagulation therapy in a timely manner. We also present a literature review on the association between nephrotic syndrome and acute stroke.

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Section: Introductionmentioning

confidence: 85%

Embolic Stroke and Nephrotic Syndrome: A Case Report and Literature Review

Androulakis

2017

OAJNN

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“…In 2014, Sasaki et al reported an additional case of ischemic stroke with NS, and reviewed 21 prior cases reported in 19 literatures [4] . However, the incidence and the clinical characteristics of AIS patients have still remained unclear [5] , [6] , [7] , [8] , [9] , [10] .…”

Section: Discussionmentioning

confidence: 99%

“…Arterial thromboses are less frequent than venous thromboses and the most common locations are femoral arteries, although other arteries may be involved [1] , [2] , [3] . Stroke associated with NS has rarely been reported in several case reports [4] , [5] , [6] , [7] , [8] , [9] , [10] . We report 10 cases of acute ischemic stroke (AIS) associated with NS and the results of a retrospective cohort study comparing AIS patients with and without NS.…”

Section: Introductionmentioning

confidence: 98%

Acute ischemic stroke associated with nephrotic syndrome: Incidence and significance — Retrospective cohort study

et al. 2015

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We report 10 cases with arterial ischemic stroke (AIS) with nephrotic syndrome (NS), and clarified its incidence and clinical characteristics. The patients having albumin less than 3.0 g/dl and serum cholesterol greater than 250 mg/dl at the same time were retrospectively screened from 11,161 cases of stroke. Furthermore, the patients of AIS showing heavy proteinuria were selected. The 10 cases were diagnosed as AIS with NS. Its incidence was 0.09% of all kinds of stroke and 0.12% of AIS. Their subtypes were 6 large-artery atherosclerosis, 3 small-vessel occlusion, and 1 cardioembolism. We carried out a retrospective cohort study to assess the association between NS and atherosclerosis progression in AIS patients. Seven AIS patients with NS due to diabetic nephropathy (cases; NS group) were compared with patients with AIS and diabetes mellitus (DM) without NS (control group). Control group subjects were matched in a 2:1 ratio to cases by age, sex, use of medications for DM, and hemoglobin A1c (HbA1c) level. The NS group had high cerebral artery atherosclerosis scores, especially in the anterior circulation. The NS group demonstrated atherosclerosis of the internal carotid and lower extremity arteries, although there were no statistical differences between the two groups. Study subjects had high serum fibrinogen and D-dimer levels, suggesting that AIS patients with NS have a greater degree of hypercoagulability than AIS patients without NS.

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Nephrotic syndrome

Liebeskind

2014

Handbook of Clinical Neurology

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Thrombosis of the Posterior Inferior Cerebellar Artery Secondary to Nephrotic Syndrome

Cited by 5 publications

References 3 publications

Embolic Stroke and Nephrotic Syndrome: A Case Report and Literature Review

Embolic Stroke and Nephrotic Syndrome: A Case Report and Literature Review

Acute ischemic stroke associated with nephrotic syndrome: Incidence and significance — Retrospective cohort study

Nephrotic syndrome

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