Thrombosis with Behçet’s disease should be evaluated different conditions

Balta, İlknur; Balta, Şevket; Demır, Mustafa; Öztürk, Cengiz; Demırkol, Sait

doi:10.11604/pamj.2015.20.117.3571

Cited by 2 publications

(3 citation statements)

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“…In patients with BD, vascular involvement and thrombotic tendency is a potentially life risk condition ( Balta et al, 2014a , Balta et al, 2014b , Balta et al, 2014c ). Deep vein thrombosis (DVT) is the most common manifestation but other organs may also be involved ( Balta et al, 2015a , Balta et al, 2015b ). Thrombotic events may be associated so many conditions and its treatment may cause serious complications ( Balta et al, 2015a , Balta et al, 2015b ).…”

Section: Introductionmentioning

confidence: 99%

“…Deep vein thrombosis (DVT) is the most common manifestation but other organs may also be involved ( Balta et al, 2015a , Balta et al, 2015b ). Thrombotic events may be associated so many conditions and its treatment may cause serious complications ( Balta et al, 2015a , Balta et al, 2015b ). More useful details should be explored to differential diagnosis BD patients with DVT and guide its treatment.…”

Section: Introductionmentioning

confidence: 99%

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HnRNP A1 is Involved in Deep Vein Thrombosis Patients with Behçet's Disease

et al. 2016

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ObjectiveThe aim of this study was to verify the hypothesis originated from bioinformatics and literature reviews that hnNRP A1 may be a new immune target of Behçet's disease (BD).MethodsFirst, bioinformatics was used to show the correlation between hnRNP A1 and A2/B1 in amino acid sequences and three dimensional structures. Second, hnRNP A1 was expressed, purified, and immunologically confirmed by systematic immunology methods including: Western blotting, immunoprecipitation and Dot-ELISA. Then, ELISA was used to screen the anti-hnRNP A1 autoantibodies in newly confirmed clinical samples and the clinical significance was compared between anti-hnRNP A1 antibody positive and negative groups. Finally, the endothelial cells antigen profile of one anti-hnRNP A1 antibody positive BD patient was detected using immunoprecipitation with liquid chromatography tandem mass spectrometry (LC–TMS).ResultsIn total 720 subjects enrolled and tested in this study. Our results demonstrated hnRNP A1 as a new immune target of BD. The reactivity of BD serum IgG antibodies against hnRNP A1 was significantly higher than healthy controls (P < 0.0001), and deep vein thrombosis (DVT) showed a significant higher in the anti-hnRNP A1 antibodies positive group (P < 0.05).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

HnRNP A1 is Involved in Deep Vein Thrombosis Patients with Behçet's Disease

et al. 2016

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“…

Antiphospholipid syndrome (AS) or antiphospholipid body syndrome is associated with arterial or venous thrombosis. This syndrome is diagnosed with determining serum antiphospholipid bodies which lead to the clinical events such as arterial or venous thrombosis [1][2][3][4][5][6][7][8][9][10]. Pathophysiology of disease is associated with activating coagulation cascade or inhibiting protein S and/or protein C by antiphospholipid bodies.

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confidence: 99%