Through the Microbial Looking Glass: Premature Labor, Preeclampsia, and Gestational Diabetes

Dunn, Alexis; Hanson, Lisa; VandeVusse, Leona; Leslie, Sharon

doi:10.1097/jpn.0000000000000375

Cited by 17 publications

(13 citation statements)

References 96 publications

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“…Numerous studies support the involvement of human microbiota and microbial translocation in preeclampsia (PE) (140)(141)(142)(143). A meta-analysis of epidemiologic studies indicated that any viral or bacterial infection relates to a higher risk of PE (two-fold) (91).…”

Section: Gut Kidney Microbiome Axis and Pregnancy-related Complicationsmentioning

confidence: 99%

Focus on the Gut–Kidney Axis in Health and Disease

et al. 2021

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The recent new developments in technology with culture-independent techniques including genome sequencing methodologies shed light on the identification of microbiota bacterial species and their role in health and disease. Microbiome is actually reported as an important predictive tool for evaluating characteristic shifts in case of disease. Our present review states the development of different renal diseases and pathologies linked to the intestinal dysbiosis, which impacts on host homeostasis. The gastrointestinal–kidney dialogue provides intriguing features in the pathogenesis of several renal diseases. Without any doubt, investigation of this interconnection consists one of the most cutting-edge areas of research with potential implications on our health.

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Section: Gut Kidney Microbiome Axis and Pregnancy-related Complicationsmentioning

confidence: 99%

Focus on the Gut–Kidney Axis in Health and Disease

et al. 2021

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“…Further, Li Juan et al demonstrated that preeclampsia is associated with a disrupted gut microbiota composition compared with that of women who had uncomplicated pregnancies (171). In a recent review of the current knowledge about the possible association between the microbiome and the development of preeclampsia, Dunn et al did a comprehensive literature search and reported that overall, five groups of investigators studied the microbiome of PEC (172). In two of the studies, the placenta site was analyzed; in the remaining three, the mouth, gut, or an intra-amniotic site was examined.…”

Section: Hypothesis For How Altered Microbiome Affects Pec and Iugrmentioning

confidence: 99%

Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota

et al. 2020

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Understanding what happens at the time of embryo implantation has been the subject of significant research. Investigators from many differing fields including maternal fetal medicine, microbiology, genetics, reproductive endocrinology and immunology have all been studying the moment the embryo interacts with the maternal endometrium. A perfect relationship between the uterus and the embryo, mediated by a tightly controlled interaction between the embryo and the endometrium, is required for successful implantation. Any factors affecting this communication, such as altered microbiome may lead to poor reproductive outcomes. Current theories suggest that altered microbiota may trigger an inflammatory response in the endometrium that affects the success of embryo implantation, as inflammatory mediators are tightly regulated during the adhesion of the blastocyst to the epithelial endometrial wall. In this review, we will highlight the various microbiome found during the periconceptual period, the microbiomes interaction with immunological responses surrounding the time of implantation, its effect on implantation, placentation and ultimately maternal and neonatal outcomes.

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“… 19 The presence of GDM, along with other risk factors such as high blood pressure and obesity during pregnancy, can also lead to premature labor and delivery. 20 Therefore, the most direct adverse pregnancy outcome of GDM patients with poor blood glucose and weight control is macrosomia, which will lead to a series of other adverse pregnancy outcomes. One study found that up to 12 hours of comprehensive nutritional care significantly reduces the incidence of macrosomia in patients with GDM.…”

Section: Discussionmentioning

confidence: 99%

The Impact of the One-Day Clinic Diabetes Mellitus Management Model on Perinatal Outcomes in Patients with Gestational Diabetes Mellitus

Cao

Wang

Cai

et al. 2021

DMSO

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Objective The aim of the present study was to explore the impact of the one-day clinic diabetes mellitus (DM) management model on perinatal outcomes in patients with gestational diabetes mellitus (GDM). Methods A total of 995 patients who underwent prenatal checkups at our hospital and were diagnosed with GDM by oral glucose tolerance test (OGTT) screening at 24–28 weeks of gestational age were enrolled between December 2018 and August 2020. The patients were randomly divided into a study group (541 cases) and a control group (454 cases). One-day clinic intervention for DM was conducted in the study group, while individualized dietary interventions and exercise instruction were given in the control group. The perinatal outcomes of patients were compared between the two groups. Results In the study group, maternal weight gain, fasting blood glucose before delivery, the incidence of abnormality in postpartum OGTT, and abnormality of pancreatic islet function were lower than in the control group, and the differences were statistically significant ( P < 0.05). The percentage of patients with insulin treatment in the study group was higher than in the control group, and the difference was statistically significant ( P < 0.05). The incidence of premature rupture of membranes, macrosomia, and neonatal jaundice was lower in the study group than in the control group, and the differences were statistically significant ( P < 0.05). Conclusion The one-day clinic DM management model can effectively control weight gain and blood glucose levels during pregnancy in patients with GDM, resulting in a higher recovery rate of blood glucose and islet function after delivery and a lower incidence of premature rupture of membranes, macrosomia, and neonatal jaundice. The one-day clinic DM management model could therefore have profound implications for reducing and delaying the onset of postpartum type 2 diabetes in patients with GDM.

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Through the Microbial Looking Glass: Premature Labor, Preeclampsia, and Gestational Diabetes

Cited by 17 publications

References 96 publications

Focus on the Gut–Kidney Axis in Health and Disease

Focus on the Gut–Kidney Axis in Health and Disease

Immunological Role of the Maternal Uterine Microbiome in Pregnancy: Pregnancies Pathologies and Alterated Microbiota

The Impact of the One-Day Clinic Diabetes Mellitus Management Model on Perinatal Outcomes in Patients with Gestational Diabetes Mellitus

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