THSD7A expression: a novel immunohistochemical determinant in predicting overall survival of metastatic renal cell carcinoma treated with targeted therapy

Aktepe, Oktay Halit; Gündoğdu, Fatma; Kösemehmetoğlu, Kemal; Yeter, Haci Hasan; Aksoy, Sercan; Güven, Deniz Can; Şahin, Taha Koray; Yüce, Deniz; Kertmen, Neyran; Dizdar, Ömer; Yalçın, Şuayib; Erman, Mustafa

doi:10.1007/s11845-021-02759-0

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Several studies indicate that THSD7A might at least play a role in the prognosis of different tumor types and that it possibly activates FAK-dependent signaling pathways [ 5 , 9 , 11 , 13 , 14 , 15 , 16 , 17 , 18 ]. The aim of this study was to examine the role of THSD7A as a potential biomarker in LSCC.…”

Section: Discussionmentioning

confidence: 99%

“…There is also evidence of the participation of THSD7A in angiogenesis [ 9 , 10 , 11 ] and an association with obesity [ 12 ]. Furthermore, several studies indicate that THSD7A might at least play a role in the prognosis of different tumor types [ 13 , 14 , 15 , 16 , 17 , 18 ]. In addition to that, other groups report on THSD7A expression in different tumor types and a possible relationship between malignant diseases and MN [ 6 , 16 , 17 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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THSD7A Positivity Predicts Poor Survival and Is Linked to High FAK Expression and FGFR1-Wildtype in Female Patients with Squamous Cell Carcinoma of the Lung

Flockerzi

Hohneck

Langer

et al. 2023

IJMS

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Lung cancer is the leading cause of cancer-related deaths in the western world, with squamous cell carcinoma being one of the most common histological subtypes. Prognostic and predictive markers are still largely missing for squamous cell carcinoma of the lung (LSCC). Several studies indicate that THSD7A might at least play a role in the prognosis of different tumors. FAK seems to play an important role in lung cancer and is discussed as a potential therapeutic target. In addition, there is evidence that FAK-dependent signaling pathways might be affected by THSD7A. For that reason, we investigated the role of THSD7A as a potential tumor marker in LSCC and whether THSD7A expression has an impact on the expression level of FAK. A total of 101 LSCCs were analyzed by immunohistochemistry using tissue microarrays. THSD7A positivity was associated with poor overall survival in female patients and showed a relation to high FAK expression in this subgroup. To our knowledge, we are the first to report these correlations in lung cancer. The results might be proof of the assumed activation of FAK-dependent signaling pathways by THSD7A and that as a membrane-associated protein, THSD7A might serve as a putative therapeutic target in LSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

THSD7A Positivity Predicts Poor Survival and Is Linked to High FAK Expression and FGFR1-Wildtype in Female Patients with Squamous Cell Carcinoma of the Lung

Flockerzi

Hohneck

Langer

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Several other studies indicate that THSD7A might play a role at least Diagnostics 2023, 13, 2211 2 of 10 in the prognosis of different tumor types. Furthermore, there are several reports on the relationship between THSD7A expression in different tumor types and the development of a membranous nephropathy [10][11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

SCARA5 Is Overexpressed in Prostate Cancer and Linked to Poor Prognosis

et al. 2023

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Prostate cancer is one of the most common malignancies worldwide, showing a wide range of clinical behaviors. Therefore, several treatment options arise out of the diagnosis “prostate cancer”. For this reason, it is desirable to find novel prognostic and predictive markers. In former studies, we showed that THSD7A expression is associated with unfavorable prognostic parameters in prostate cancer and is linked to a high expression of focal adhesion kinase (FAK). Recently, scavenger receptor class A member 5 (SCARA5) was reported to be the downstream gene of THSD7A in esophageal squamous cell carcinoma. SCARA5 is believed to play an important role in the development and progression of several different tumor types. Most studies describe SCARA5 as a tumor suppressor. There is also evidence that SCARA 5 interacts with FAK. To examine the role of SCARA5 as a potential biomarker in prostate cancer, a total of 461 prostate cancers were analyzed via immunohistochemistry using tissue microarrays. Furthermore, we compared the expression level of SCARA5 with our previously collected data on THSD7A and FAK. High SCARA5 expression was associated with advanced tumor stage (p < 0.001), positive nodal status (p < 0.001) and high Gleason-score (p < 0.001). At least, strongly SCARA5-positive cancers were associated with THSD7A-positivity. There was no significant association between SCARA5 expression level and FAK expression level. To our knowledge, we are the first to investigate the role of SCARA5 in prostate cancer and we demonstrated that SCARA5 might be a potential biomarker in prostate cancer.

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THSD7A as a Promising Biomarker for Membranous Nephrosis

Jiang,

Lian

et al. 2023

Mol Biotechnol

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THSD7A expression: a novel immunohistochemical determinant in predicting overall survival of metastatic renal cell carcinoma treated with targeted therapy

Cited by 5 publications

References 25 publications

THSD7A Positivity Predicts Poor Survival and Is Linked to High FAK Expression and FGFR1-Wildtype in Female Patients with Squamous Cell Carcinoma of the Lung

THSD7A Positivity Predicts Poor Survival and Is Linked to High FAK Expression and FGFR1-Wildtype in Female Patients with Squamous Cell Carcinoma of the Lung

SCARA5 Is Overexpressed in Prostate Cancer and Linked to Poor Prognosis

THSD7A as a Promising Biomarker for Membranous Nephrosis

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