Thymic carcinoma

Snover, Dale C.; Levine, Gerald D.; Rosaí, Juan

doi:10.1097/00000478-198207000-00007

Cited by 223 publications

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“…Some genetic studies suggested that combined thymic epithelial tumors could arise by dedifferentiation of thymoma/thymic carcinoma or by biphasic differentiation of a multipotential thymic epithelial precursor. However, the concept of tumor collision awaits genetic evidence [3]. Clinically, almost all reported cases of combined thymic tumors were observed in the anterior mediastinum, and there were no differences in the clinical manifestations of combined tumors as compared to the individual component.…”

Section: Discussionmentioning

confidence: 99%

“…Primary thymic MEC is rare. It was first described by Snover DC and his colleagues in 1982 [3]. Since then, no more than 30 cases have been reported in the English literature [4-15].…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that thymic MECs might arise from thymic epithelium because, in some cases, a transition between tumor cells and benign cyst-lining epithelium and the finding of residual non-neoplastic thymic parenchyma within the walls of the cysts has been reported in some cases [7]. However, pluripotent epithelial stem cells of endodermal origin have been also postulated in the pathogenesis of MEC of the thymus by some authors [3]. A strong association between MEC and t (11; 19) (q21; p13) has been observed in non-thymic anatomical sites [24,25].…”

Section: Discussionmentioning

confidence: 99%

“…Mucoepidermoid carcinoma (MEC) of the thymus is rare in thymic caircinoma, and comprises approximately 2% of published thymic carcinoma [1,2]. Up to date, no more than 30 cases of thymic MEC have been described in the literature [3-15]. In rare condition, combined thymic epithelial tumors showing either type A or type B thymomas areas combined with thymic carcinoma components may occur primarily in thymus, and are exceptionally rare (<1%) [16].…”

Section: Introductionmentioning

confidence: 99%

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Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature

et al. 2014

Diagn Pathol

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BackgroundIn rare condition, combined thymic epithelial tumors showing either type A or type B thymomas areas combined with thymic carcinoma components may occur in thymus. Mucoepidermoid carcinoma (MEC) of the thymus is rare in thymic carcinoma, and so far there is no report to describe a combined epithelial tumor of thymus with MEC component. We report an unusual case of combined thymic MEC/type B2 thymoma in a middle-aged male occurring in a mass of anterior mediastinum. Case report: A 51-year-old Chinese male patient presented with a 6-month history of right ptosis and progressive muscle weakness. Computed tomography (CT) examination revealed a solitary, well-circumscribed mass was in the anterior mediastinum with mild heterogeneous enhancement. Histologically, the mass contained two separated components and displayed typically histological features of low-grade MEC and type B2 thymoma, respectively. There was no gradual transition of these two components observed in mass, and no enlarged lymph node was found in the surrounding tissues. A diagnosis of combined thymic MEC/type B2 thymoma was made. The patient received thymectomy to resect the mass totally. After surgery, chemotherapy with regiments of cisplatin and mitomycin, and radiotherapy of the main tumor bed were performed on the patient. There was no evidence of tumor recurrence during the period of 12 months follow-up.ConclusionTo our best knowledge, this is the first report of combined thymic epithelial tumor with MEC component. Although this tumor is rare, the diagnosis of a thymic MEC should be taken into consideration when a combined epithelial tumor is occasionally encountered in thymus.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9721397571157894

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Section: Discussionmentioning

confidence: 99%

“…Primary thymic MEC is rare. It was first described by Snover DC and his colleagues in 1982 [3]. Since then, no more than 30 cases have been reported in the English literature [4-15].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature

et al. 2014

Diagn Pathol

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“…In contras t to thy momas th ey s how ad en osquamous, basal oid , sa rcom a toid, and undifferentiated ca rcinomas (7). Mucoepidermoid ca rci nom a of thymus is extre me ly rare and was first described in 1982 (3,5) with on ly tw o cases bein g documented . This tumour is cytologica lly similar to low gr ad e mucoepidermoid tumour of saliva ry glands (6).…”

Section: Discussionmentioning

confidence: 99%

Primary Mucoepidermoid Carcinoma of the Thymus - A Rare Cause of Mediastinal Tumour

Brightman¹,

Ja²,

Wp³

et al. 1992

Thorac cardiovasc Surg

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Spindle-cell lesions of the mediastinum: Diagnosis by fine-needle aspiration biopsy

et al. 1997

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Spindle cells seen in fine‐needle aspiration biopsy (FNAB) of the mediastinal lesions can be a component of a wide variety of benign and malignant conditions. Few of these conditions, however, are described in the FNA cytopathology literature. This review discusses the cytopathologic features, differential diagnoses, and potential pitfalls of a variety of lesions with a significant component of spindle cells encountered in mediastinal FNAB. The cytopathology files from four institutions were searched for cases of mediastinal FNAB containing a spindle‐cell component that was a key or predominant cytologic feature of the diagnostic specimen. The cytomorphologic features of these cases were analyzed, and their differential features are discussed. Of 196 mediastinal FNABs, 22 (11%) were lesions with significant spindle‐cell component: granulomatous inflammation (four); benign nerve sheath tumor (four); thymic cyst (two); spindle‐cell thymoma (two); large‐cell non‐Hodgkin's lymphoma with sclerosis (two); nodular sclerosing Hodgkin's disease (two); liposarcoma (two); spindle‐cell squamous carcinoma possibly arising in a teratoma (one); unspecified high‐grade sarcoma (one); spindle‐cell malignant melanoma (one); and nonspecific fibrous tissue (one). The cytologic features of each lesion were analyzed as an aid for accurate classification. These findings were correlated with radiologic and clinical information when available. The value of ancillary studies performed on aspirated material in selected cases was also reviewed. FNA of mediastinal lesions with significant spindle‐cell morphology represents an infrequent and heterogeneous group of entities that may pose significant diagnostic challenges. This review presents the salient cytopathologic features of various spindle‐cell lesions of the mediastinum with particular emphasis on differential diagnosis and pitfalls. The pathologist must use caution when interpreting these lesions and ancillary studies may be of significant value in selected cases. Diagn. Cytopathol. 1997;17:167–176. © 1997 Wiley‐Liss, Inc.

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Thymic carcinoma

Cited by 223 publications

References 0 publications

Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature

Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature

Primary Mucoepidermoid Carcinoma of the Thymus - A Rare Cause of Mediastinal Tumour

Spindle-cell lesions of the mediastinum: Diagnosis by fine-needle aspiration biopsy

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