1997
DOI: 10.1002/(sici)1097-0339(199709)17:3<167::aid-dc1>3.0.co;2-c
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Spindle-cell lesions of the mediastinum: Diagnosis by fine-needle aspiration biopsy

Abstract: Spindle cells seen in fine‐needle aspiration biopsy (FNAB) of the mediastinal lesions can be a component of a wide variety of benign and malignant conditions. Few of these conditions, however, are described in the FNA cytopathology literature. This review discusses the cytopathologic features, differential diagnoses, and potential pitfalls of a variety of lesions with a significant component of spindle cells encountered in mediastinal FNAB. The cytopathology files from four institutions were searched for cases… Show more

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Cited by 47 publications
(20 citation statements)
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“…The rarity is demonstrated by the fact that only 4 cases of mediastinal melanomas have been reported on histology and that in only 1 case was there a report on the aspiration cytology findings. [1][2][3][4] Mediastinal melanomas can be primary or represent mediastinal metastases from a primary elsewhere. In the latter the mediastinal nodes are involved as part of a generalized dissemination process in patients with a known primary tumor.…”
Section: Discussionmentioning
confidence: 99%
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“…The rarity is demonstrated by the fact that only 4 cases of mediastinal melanomas have been reported on histology and that in only 1 case was there a report on the aspiration cytology findings. [1][2][3][4] Mediastinal melanomas can be primary or represent mediastinal metastases from a primary elsewhere. In the latter the mediastinal nodes are involved as part of a generalized dissemination process in patients with a known primary tumor.…”
Section: Discussionmentioning
confidence: 99%
“…1 Mediastinal melanoma is extremely rare: only 4 cases have been reported. [2][3][4][5][6] Though cytologists are extremely familiar with the features of melanomas on fine needle aspiration cytology (FNAC), at a rare location like the mediastinum they may have problems making this diagnosis.…”
mentioning
confidence: 99%
“…5,29,39,[48][49][50][51][52][53][54][55] Limitations of fine-needle aspiration cytology, however, include inability in detailed subtyping of thymoma according to the World Health Organization classification, as well as in determining capsular invasion.…”
Section: Neoplastic Lesions Thymomamentioning
confidence: 99%
“…However, the fibrous matrix sometimes causes cellular distortion, resulting in an elongated or a spindly appearance of the lymphoma cells. 39,53,96,98 The diagnosis of lymphoma can be confirmed by immunocytochemical study or flow cytometry. Flow cytometry is a useful adjunctive investigation in diagnosis of even some rare types of lymphoma.…”
Section: Primary Mediastinal Large B-cell Lymphomamentioning
confidence: 99%
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