Thymic cell migration in the subnodular spaces of draining lymph nodes of rats

Sainte-Marie, G; Peng, F.‐S.

doi:10.1016/0008-8749(80)90413-x

Cited by 18 publications

(4 citation statements)

References 9 publications

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“…5f). This area contains a conduit for migrating cells and small molecules, such as chemokines: they are transported into the superficial cortex and then to the subfollicular area (Sainte-Marie and Peng, 1980;Katakai et al, 2004). Because large molecules do not enter this conduit, the presence of a certain gate is suggested (Gretz et al, 2000).…”

Section: Afferent Lymphatic and Marginal Sinus In The Lymph Nodesmentioning

confidence: 99%

The microstructure of secondary lymphoid organs that support immune cell trafficking

Matsuno¹,

Ueta

Shu

et al. 2010

Arch. Histol. Cytol.

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Section: Afferent Lymphatic and Marginal Sinus In The Lymph Nodesmentioning

confidence: 99%

The microstructure of secondary lymphoid organs that support immune cell trafficking

Matsuno¹,

Ueta

Shu

et al. 2010

Arch. Histol. Cytol.

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“…Moreover, we proposed that immunogenic information is transmitted to the plasmocytic population of the cords by lymphocytes from the afferent lymph. These cells would migrate across the extrafollicular zone and along the periphery of a deep cortical unit to enter the contiguous medullary cords of a given compartment (Sainte-Marie and Peng, 1980). This would yield a compartmentation of the medulla paralleling that of the cortex with no more overlapping of stimuli in the medulla than in the cortex.…”

Section: Physiological Compartmentsmentioning

confidence: 99%

Overall architecture and pattern of lymph flow in the rat lymph node

1982

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The immunogenic content of the afferent lymph stimulates structures in the lymph node. Thus, a better knowledge of the processes of lymph flow and filtration in the organ should help us better understand various aspects of the node's function. To gain this understanding, we analyzed the distribution of flow in rat node draining areas locally injected with a small dose of China ink. Because the lymph-flow pattern is likely related to the overall architecture of the node, we simultaneously studied its morphology. Indeed, while the different structures of the node are known, some aspects of its overall architecture need to be resolved. The present work aimed to accomplish this by an analysis of semiserial sections of nodes from various anatomical locations in normal rats; the sections were stained by the Dominici technique or silver-impregnated.With respect to their architecture, the nodes could be distinguished into those with either a discontinuous or a continuous subcapsular sinus and peripheral cortex. These are referred to here, respectively, as segmented and nonsegmented nodes. In the segmented nodes, the subcapsular sinus with the peripheral cortex is separated by "gaps," in which medullary sinuses reached the capsule. Further, a node appears to be divided into one or more "physiological compartments," each one representing a nodal area related to an opening of an afferent lymphatic.The findings on China-ink distribution indicate that the lymph-flow pattern varies in different nodes and is determined by the particular architecture of a node, i.e., the lymph flow in a given node aligns itself along the pattern of segmentation of the organ. The findings suggest that the lymph content is first held by the endothelium lining the inner wall of a restricted area of the subcapsular sinus in a concentration which decreases with the distance from the related afferent lymphatic opening. Part of the content, possibly its nonimmunogenic fraction, would later be released to flow further along the sinus. It would then be phagocytosed by the macrophage accumulation located in the portions of medullary sinuses into which the lymph enters from the subcapsular sinus. The lymph thus filtered then flows along the medullary sinuses and leaves the organ. The latter findings also indicate that a node is divided into physiological compartments, each one being stimulated by the lymph from a given afferent lymphatic opening. As the immunogenic content of the lymph can differ from one lymphatic to another, this explains the frequent variations in similar structures located in different areas of a given node. Hence, the pattern of distribution of the openings of the afferent lymphatics of a node can account for the particularities of its overall architecture and its division into physiological compartments.

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“…The reason for this may be that there is an optimal size for a unit, which corresponds roughly to that observed in the smaller species such as the rat and the mouse. Larger units could be unfavorable to the organism since lymphocyte migration takes place through the thickness of the units (SainteMarie and Peng, 1980). Hence, the larger or thicker the unit, the more time would be required for lymphocytes to migrate through it.…”

mentioning

confidence: 99%

Topography of the deep cortex of the lymph nodes of various mammalian species

Bélisle

Sainte-Marie

1981

Anat. Rec.

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In preceeding studies, we clarified the histology of the deep cortex of the rat lymph node. It was shown that the deep cortex is made up of basic elements termed "deep cortex units,' some of which are fused to one another into "deep cortex complexes.' Each unit is a semirounded lymphocytic structure, centered on the opening of an afferent lymphatic, contiguous to the peripheral cortex, and bulging into the medulla of a node. Moreover, each unit comprises a "center' and a "periphery,' bearing distinct morphological features. The present work was undertaken to verify whether the histology of the deep cortex of nodes form various species of mammals, currently used or experimental immunology, is comparable to that of the rate. The observations yielded a positive answer to the question.

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Thymic cell migration in the subnodular spaces of draining lymph nodes of rats

Cited by 18 publications

References 9 publications

The microstructure of secondary lymphoid organs that support immune cell trafficking

The microstructure of secondary lymphoid organs that support immune cell trafficking

Overall architecture and pattern of lymph flow in the rat lymph node

Topography of the deep cortex of the lymph nodes of various mammalian species

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