Thymidine phosphorylase/platelet-derived endothelial cell growth factor (PD-ECGF) associated with prognosis in renal cell carcinoma

Suzuki, Kaoru; Morita, Tatsuo; Hashimoto, S.; Tokue, Akihiko

doi:10.1007/s002400000154

Cited by 23 publications

(25 citation statements)

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“…The median ( SD , range) diameter for all 54 tumours was 7.5 (2.85, [3][4][5][6][7][8][9][10][11][12][13][14] cm; a large tumour was defined as having a diameter of > 7 cm. The MVD was significantly different between the 28 large and 26 small tumours ( P = 0.005; Table 1).…”

Section: Resultsmentioning

confidence: 99%

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Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

et al. 2007

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OBJECTIVE To clarify the significance of microvessel density (MVD) in a retrospective investigation the relationship between the pattern of MVD (reflecting angiogenesis), and tumour stage, grade, size, and occurrence of microvessel invasion (MVI), metastasis, and cancer‐specific survival (CSS) in patients who had surgery for renal cell carcinoma (RCC). PATIENTS AND METHODS Vessels were labelled in sections of formalin‐fixed, paraffin‐embedded tissues from 54 RCCs by CD34 immunohistochemistry. The mean MVD, expressed as the number of vessels per 10 high‐power fields (HPF, ×400) were measured for each case. In addition, all pathological slides were reviewed for the presence and absence of MVI. The prognostic value of MVD and MVI was then evaluated, and correlated with the usual prognostic variables, tumour metastasis and CSS. RESULTS In a univariate analysis of CSS, the MDV tended to be lower as stage increased from pT1 to pT3, and as grade increased from G1 to G4, although it was statistically significant only for stage (P < 0.001 and 0.050, respectively). The mean MVD was higher in 42 nonmetastatic than in 12 metastatic tumours, and in 33 tumours associated with MVI than in 21 with no MVI (P < 0.001). The mean MVD was also lower and significantly different for 28 large than 26 small tumours (P = 0.005). The survival rate of patients with tumours that were small, low‐stage, of higher MVD, with no MVI and metastasis was significantly higher than that of patients with large, high‐stage, low MVD, with MVI and metastatic tumours (all P < 0.001). MVI was significantly more common with a decreasing trend in MVD and the presence of metastasis (Spearman rank correlation rs = −0.68, P = 0.01, and rs = 0.39, P = 0.01, respectively). Independent prognostic factors in a multivariate analysis were: in all patients with RCC, tumour stage (P = 0.013) and metastasis (P = 0.028); in those with low MVD, MVI (P = 0.004) and metastases (P = 0.016); in those with no MVI, stage (P = 0.020); in those with MVI, MVD (P = 0.001); in those with no metastases, stage (P = 0.045); and in those with metastases, MVD (P < 0.001). No independent predictor was identified in patients with high MVD. In patients with no metastases there was a significantly shorter median CSS time in RCCs with low MVD and with MVI (P = 0.004 for both). Similarly, patients who had grade 3–4 tumours, vs those with lower MVD and with MVI, had a significantly shorter median CSS (P = 0.020 for MVD, and 0.01 for MVI). CONCLUSIONS This study suggested that MVD in RCC was inversely associated with MVI, tumour metastasis, patient survival and tumour diameter and stage, from the usual prognostic variables, but MVD was not an independent prognostic factor in multivariate analysis for all patients with RCC. Low MVD and the presence of MVI appears to be a marker for identifying patients with an adverse prognosis.

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Section: Resultsmentioning

confidence: 99%

“…Yoshino et al [2] and Paradis et al [3] reported that patient survival was significantly correlated with microvessel density (MVD), while others [4][5][6] reported that MVD did not correlate with metastasis. By contrast, others [7][8][9] reported that a higher MVD was associated with longer patient survival.…”

Section: Introductionmentioning

confidence: 99%

Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

et al. 2007

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“…12 Suzuki et al also reported that MVD had no predictive value for cancerspecific survival. 13 Slaton et al found no correlation between MVD and metastasis.…”

Section: Discussionmentioning

confidence: 97%

“…12 and Suzuki et al . 13 reported MVD had no predictive value for cancerspecific survival. Similarly, Slaton et al .…”

Section: Introductionmentioning

confidence: 95%

Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinoma

et al. 2004

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Background : Although a correlation between microvessel density (MVD) and tumor aggressiveness has been established for several malignancies, the data for renal cell carcinoma (RCC) is conflicting. In order to clarify the significance of MVD, we investigated the relationships between MVD and tumor stage, grade, size, occurrence of metastasis and patient survival. Methods : Tumor specimens from 70 patients with primary renal cell carcinoma were examined by immunohistochemical staining for CD34.Results : There was a tendency for MVD to decrease from G1 to G3 tumors or from stage T1 to T3 tumors, although this was not statistically significant. However, the MVD for 56 non-metastatic and 14 metastatic tumors were significantly different ( P = 0.005) at 109 ± 67 and 58 ± 35 per ¥ 400 field (mean ± SD), respectively. Microvessel density for 36 large and 34 small tumors was also significantly different ( P < 0.0001) at 48 ± 22 and 142 ± 54 per ¥ 400 field, respectively. The survival rate of patients with small, low grade and hypervascular tumors was significantly higher than that of patients with large ( P = 0.0015), high grade ( P = 0.05) or low MVD ( P = 0.039) tumors. Cox proportional hazards regression analysis showed that tumor grade and size emerged as independent prognostic factors. Conclusion : High MVD in RCC was inversely associated with tumor aggressiveness, but MVD was not the independent prognostic factor.

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“…For most of solid tumours, microvessel density (MVD) correlates with poor prognosis. However, MVD remains a controversial prognostic predictor for RCC (Kirkali et al, 2001;Sabo et al, 2001a;Suzuki et al, 2001;Dekel et al, 2002;Kinouchi et al, 2003;Yildiz et al, 2008;Qian et al, 2009), a significant contributory factor being that blood vessels in RCC may be regarded as being monolithic in structure and function, which might not accurately reflect the functional diversity based on microvessel differentiation and location. Mature blood vessels are usually covered by pericytes, and pericyte coverage is regarded as an indicator of vascular maturation (Gerhardt and Semb, 2008).…”

Section: Hai-lun Zhan Xin Gao* Xiang-fu Zhou Xiao-yong Pu De-juanmentioning

confidence: 99%

Presence of Tumour-infiltrating FOXP3⁺Lymphocytes Correlates with Immature Tumour Angiogenesis in Renal Cell Carcinomas

Zhan

Gao²,

Zhou³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Thymidine phosphorylase/platelet-derived endothelial cell growth factor (PD-ECGF) associated with prognosis in renal cell carcinoma

Cited by 23 publications

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Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinoma

Presence of Tumour-infiltrating FOXP3⁺Lymphocytes Correlates with Immature Tumour Angiogenesis in Renal Cell Carcinomas

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Thymidine phosphorylase/platelet-derived endothelial cell growth factor (PD-ECGF) associated with prognosis in renal cell carcinoma

Cited by 23 publications

References 0 publications

Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma

Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinoma

Presence of Tumour-infiltrating FOXP3+Lymphocytes Correlates with Immature Tumour Angiogenesis in Renal Cell Carcinomas

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Presence of Tumour-infiltrating FOXP3⁺Lymphocytes Correlates with Immature Tumour Angiogenesis in Renal Cell Carcinomas