Thymolipoma. A report of nine cases, with emphasis on its association with myasthenia gravis

Rieker, Ralf J.; Schirmacher, Peter; Moser, Katharina; Hoffmann, Hans; Dienemann, Hendrik; Pfannschmidt, Joachim

doi:10.1007/s00595-009-4042-5

Cited by 40 publications

(57 citation statements)

References 22 publications

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“…It usually presents in young age, mean age of 22–26 years, and there is no sex predilection. In some of the series, 40% of patients with thymolipoma had autoimmune diseases like myasthenia gravis,1 5 6 vitamin B 12 deficiency, hypogammaglobulinemia and aplastic anaemia. Those patients with autoimmune disease symptoms may show improvement of their symptoms after resection of the tumour.…”

Section: Discussionmentioning

confidence: 99%

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Huge mediastinal mass with minimal symptoms: thymolipoma

et al. 2011

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A 35-year-old Indian working in Dubai had come to India for his annual vacation. He presented with a shortness of breath and mild chest discomfort of 3 months duration. Routine investigations gave normal results, except for his chest x-ray that showed homogenous opacity in the right mid and lower zones. Chest CT scan revealed a huge mass with fat and soft tissue involving the anterior mediastinum predominantly on the right side extending into the pericardiac region. The mass was pushing the right hemidiaphragm inferiorly and was compressing the right lung superiorly with atelectasis. The patient underwent surgical excision of the mass and recovered uneventfully. Gross specimen showed an encapsulated mass weighing 2.585 kg. Histopathological examination revealed lobules of mature adipose tissue interspersed with islands of mature thymic tissue and prominent Hassal's corpuscles suggesting thymolipoma. There was no evidence of malignancy.

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Section: Discussionmentioning

confidence: 99%

“…Thymolipomas are rare benign thymic neoplasms of anterior mediastinum, constituting fewer than 9% of tumours of the thymus 1 2. They are made up of well-differentiated adipose and thymic tissues.…”

Section: Discussionmentioning

confidence: 99%

Huge mediastinal mass with minimal symptoms: thymolipoma

et al. 2011

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Section: Discussionmentioning

confidence: 99%

“…The tumor in the present patient was a benign tumor consisting of thymic and adipose tissue. The thymic tissue component in thymolipomas, in contrast to thymomas, is separated by large amounts of mature fat with no atypia and no mitotic activity (5). Ringe et al reported that half of patients with thymolipoma were asymptomatic, and most cases were coincidentally found to have cardiomegaly on chest X-ray (8).…”

Section: Discussionmentioning

confidence: 99%

Thoracoscopic resection for mediastinal thymolipoma in a child

Furukawa

Sakai

Higashi

et al. 2018

Asian J Endoscop Surgery

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Thymolipoma is a rare disease among benign tumors. We herein report the case of a child who underwent thoracoscopic resection of a large thymolipoma. A 3-year-old boy was diagnosed with an anterior mediastinal solid tumor. Thoracic imaging revealed a fat density mass that was 8.0 × 5.0 × 3.5 cm in size. Given the MRI findings of the tumor, we suspected that the lesion was a teratoma. We decided to perform thoracoscopic exploration and, if possible, resection of the solid tumor sequentially. We successfully resected the tumor thoracoscopically. A histological examination revealed thymolipoma. For large mediastinal tumors in the intrathoracic space in children, the thoracoscopic approach is recommended when the tumor is preoperatively considered to be benign and resectable.

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“…10 Comparable lesions in the breast, thyroid, thymus, and skin have been classified in the same sense as thymolipoma 47 and adenolipoma. 22,48 In contrast, oncocytic lipoepithelial lesions tend to be predominantly epithelial, thus meriting the designation lipoadenoma to emphasize the predominance of the abnormal oncocytic epithelial component.…”

Section: Discussionmentioning

confidence: 99%

Lipomatous Salivary Gland Tumors

Agaimy

Ihrler²,

Märkl

et al. 2013

American Journal of Surgical Pathology

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Lipomatous neoplasms of the salivary glands are rare. Their wide histologic spectrum has not been sufficiently studied. We collected 31 fat-containing salivary gland lesions excluding pleomorphic adenoma and myoepithelioma with lipometaplasia. There were 19 male and 12 female patients aged 7 to 89 years (mean, 53 y). Tumors originated in the parotid (n=29) and the submandibular (n=2) gland. On the basis of the proportion and distribution of adipose tissue and the epithelial type, tumors could be categorized into 3 main groups: ordinary lipoma (n=20) identical to soft tissue lipoma but located within the salivary gland, oncocytic lipoadenoma (n=6) composed predominantly of oncocytes with variable fatty component, nononcocytic sialolipoma (n=4) composed of lobular fatty tissue (≥70%) with evenly distributed normal salivary tissue recapitulating the composition of normal salivary glands and microcystic lipoadenoma (n=1) composed of cystic ducts admixed with adipose tissue. The mean tumor size was 3.3, 3.8, and 2.9 cm for lipoma, oncocytic lipoadenoma, and nononcocytic sialolipoma, respectively. Associated diseases included Madelung disease with bilateral atypical lipomatous tumors of the neck and bilateral parotid lipoma (1), oncocytic lipoadenoma after irradiation for sinonasal adenocarcinoma (1), and periparotideal lipoma excised years before oncocytic lipoadenoma (1) and nononcocytic sialolipoma (1). No recurrence was recorded at a mean follow-up of 72 months (range, 6 to 184 mo). Sebaceous islands were seen in 5/6 oncocytic lipoadenomas and in 2/4 sialolipomas. Periductal inflammation/fibrosis was common in sialolipoma and oncocytic lipoadenoma. This study demonstrates the wide morphologic spectrum of fatty salivary gland lesions. Oncocytic lipoadenoma is an epithelial-predominant tumor that is distinct from the fat-dominated nononcocytic sialolipoma, but the 2 types seem to merge in some cases.

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Thymolipoma. A report of nine cases, with emphasis on its association with myasthenia gravis

Abstract: Thymolipomas are benign tumors that show an excellent outcome. Patients with autoimmune disease symptoms occasionally show an improvement of the symptoms after a resection of the tumors.

Cited by 40 publications

References 22 publications

Huge mediastinal mass with minimal symptoms: thymolipoma

Huge mediastinal mass with minimal symptoms: thymolipoma

Thoracoscopic resection for mediastinal thymolipoma in a child

Lipomatous Salivary Gland Tumors

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