Thymoquinone Ameliorates Lung Inflammation and Pathological Changes Observed in Lipopolysaccharide-Induced Lung Injury

Khazdair, Mohammad Reza; Bargi, Rahimeh; Saadat, Saeideh; Memarzia, Arghavan; Roshan, Nema Mohamadian; Hosseini, Mahmoud; Askari, Vahid Reza; Boskabady, Mohammad Hossein

doi:10.1155/2021/6681729

Cited by 17 publications

(6 citation statements)

References 46 publications

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“…The treatment with TQ has shown a significant role in the improvement of such pathological changes in these tissues. In addition, TQ shows a protective effect on LPS-caused inflammation in the lung and pathological changes in the lung tissue, which suggests the therapeutic role of TQ in lung injury [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Thymoquinone, an Active Compound of Nigella sativa, on Rats with Benzo(a)pyrene-Induced Lung Injury through Regulation of Oxidative Stress and Inflammation

et al. 2021

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Benzopyrene [B(a)P] is a well-recognized environmental carcinogen, which promotes oxidative stress, inflammation, and other metabolic complications. In the current study, the therapeutic effects of thymoquinone (TQ) against B(a)P-induced lung injury in experimental rats were examined. B(a)P used at 50 mg/kg b.w. induced lung injury that was investigated via the evaluation of lipid profile, inflammatory markers, nitric oxide (NO), and malondialdehyde (MDA) levels. B(a)P also led to a decrease in superoxide dismutase (SOD) (34.3 vs. 58.5 U/mg protein), glutathione peroxidase (GPx) (42.4 vs. 72.8 U/mg protein), catalase (CAT) (21.2 vs. 30.5 U/mg protein), and total antioxidant capacity compared to normal animals. Treatment with TQ, used at 50 mg/kg b.w., led to a significant reduction in triglycerides (TG) (196.2 vs. 233.7 mg/dL), total cholesterol (TC) (107.2 vs. 129.3 mg/dL), and inflammatory markers and increased the antioxidant enzyme level in comparison with the group that was administered B(a)P only (p < 0.05). B(a)P administration led to the thickening of lung epithelium, increased inflammatory cell infiltration, damaged lung tissue architecture, and led to accumulation of collagen fibres as studied through haematoxylin and eosin (H&E), Sirius red, and Masson’s trichrome staining. Moreover, the recognition of apoptotic nuclei and expression pattern of NF-κB were evaluated through the TUNEL assay and immunohistochemistry, respectively. The histopathological changes were found to be considerably low in the TQ-treated animal group. The TUNEL-positive cells increased significantly in the B(a)P-induced group, whereas the TQ-treated group showed a decreased apoptosis rate. Significantly high cytoplasmic expression of NF-κB in the B(a)P-induced group was seen, and this expression was prominently reduced in the TQ-treated group. Our results suggest that TQ can be used in the protection against benzopyrene-caused lung injury.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Thymoquinone, an Active Compound of Nigella sativa, on Rats with Benzo(a)pyrene-Induced Lung Injury through Regulation of Oxidative Stress and Inflammation

et al. 2021

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“…TQ limited pulmonary injury and inflammation caused by LPS-challenge [140]. TQ oil capsules (500 mg/ day) was found to beneficial for chronic obstructive pulmonary disease therapy [141].…”

Section: Effects Of Tq On Respiratory Disordersmentioning

confidence: 99%

Occurrence and Bioactivity Diversity of Thymoquinone: An Overview

Samra

Ahmed

Shaker³

et al. 2022

Octahedron Drug Research

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Nigella sativa L. seeds are traditionally known for their ability to cure different diseases including airway and digestive system disorders, back pain, chronic headache, paralysis, diabetes, hypertension, and skin diseases. Keeping in view the numerous traditional medicinal uses of N. sativa seeds which may be related to thymoquinone (TQ), the main component of its essential oil, we provide an overview of the biological efficacy and toxicology of TQ to support their therapeutic potential in treatment of human diseases. The current review covers the recent literature from 2002 to 2021. The data was collected from books, journals, electronic searches (Pub Med, ScienceDirect, Google Scholar, and Springerlink), and theses. Thymoquinone exhibits importance in combating various diseases such as inflammation, arthritis, ulcerative colitis, cancer. Also, it showed ability to cure neuropathic pain, male infertility, diabetes, hepatitis, cardiovascular, musculoskeletal, respiratory, renal, skin, microbial infection, and neurodegenerative diseases comprising Parkinson's and Alzheimer's. That explains the traditional uses of N. sativa seeds in folk remedies in curing different ailments. The current review provides an explanation of the ethnopharmacological uses of N. sativa L. seeds which are related to the pharmacological activities of TQ. The pharmacological properties, pharmacokinetics, efficacy, high therapeutic index, lipophilicity, and safety margin make TQ a hopeful candidate for drug development.

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“…Phytomedicine, due to its antioxidant, anti-inflammatory, and immunoregulatory effects, was used for the treatment of various diseases [20][21][22]. The effect of thymoquinone (TQ), the main component of Nigella sativa seeds, on LPS-induced lung injury in rats significantly improved lung pathological changes and the levels of cytokines (TGF-β1, INF-γ, PGE2, and IL-4) in bronchoalveolar lavage fluid (BALF) compared to the LPS-treated group [23]. The effects of hydroethanol extract Zataria multiflora on learning and memory capacity in LPS-challenged rats also remarkably reduced IL-6, malondialdehyde (MDA), and nitric oxide (NO) metabolite concentrations, but increased thiol content, superoxide dismutase (SOD), and catalase (CAT) activities [24].…”

Section: Introductionmentioning

confidence: 99%

Effects of Herbs and Derived Natural Products on Lipopolysaccharide-Induced Toxicity: A Literature Review

Kianmehr

Behdadfard

Hedayati-Moghadam

et al. 2023

Oxidative Medicine and Cellular Longevity

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Introduction. Oxidative stress (OS) during inflammation can increase inflammatory responses and damage tissue. Lipopolysaccharide (LPS) can induce oxidative stress and inflammation in several organs. Natural products have several biological activities including anti-inflammatory, antioxidant, and immunoregulatory properties. The aims of the study are to study the possible therapeutic effects of natural products on LPS inducing toxicity on the nervous system, lung, liver, and immune system. Methods. The in vitro and in vivo research articles that were published in the last 5 years were included in the current study. The keywords included “lipopolysaccharide,” “toxicity,” “natural products,” and “plant extract” were searched in different databases such as Scopus, PubMed, and Google Scholar until October 2021. Results. The results of most studies indicated that some medicinal herbs and their potent natural products can help to prevent, treat, and manage LPS-induced toxicity. Medicinal herbs and plant-derived natural products showed promising effects on managing and treating oxidative stress, inflammation, and immunomodulation by several mechanisms. Conclusion. However, these findings provide information about natural products for the prevention and treatment of LPS-induced toxicity, but the scientific validation of natural products requires more evidence on animal models to replace modern commercial medicine.

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Thymoquinone Ameliorates Lung Inflammation and Pathological Changes Observed in Lipopolysaccharide-Induced Lung Injury

Cited by 17 publications

References 46 publications

Protective Effects of Thymoquinone, an Active Compound of Nigella sativa, on Rats with Benzo(a)pyrene-Induced Lung Injury through Regulation of Oxidative Stress and Inflammation

Protective Effects of Thymoquinone, an Active Compound of Nigella sativa, on Rats with Benzo(a)pyrene-Induced Lung Injury through Regulation of Oxidative Stress and Inflammation

Occurrence and Bioactivity Diversity of Thymoquinone: An Overview

Effects of Herbs and Derived Natural Products on Lipopolysaccharide-Induced Toxicity: A Literature Review

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