Thymoquinone improves behavioral and biochemical deficits in hepatic encephalopathy induced by thioacetamide in rats

Hajipour, Somayeh; Farbood, Yaghoob; Dianat, Mahin; Rashno, Mohammad; Khorsandi, Laya Sadat; Sarkaki, Alireza

doi:10.1016/j.neulet.2020.135617

Cited by 16 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oral administration of the berberine (5, 10, and 15 mg/kg, for 1 week) to rats significantly increased total SOD (T‐SOD), CAT, GSH, and reduced MDA and ROS levels in the rat model of liver injury (Han et al, 2019). In thioacetamide‐induced liver cirrhosis and hepatic encephalopathy in rats, intraperitoneal administration of the berberine (10, 30, and 60 mg/kg, for 1 week) significantly increased GPx activity and decreased MDA level in the hippocampal tissue (Hajipour et al, 2023).…”

Section: Resultsmentioning

confidence: 99%

Anti‐inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review

Shakeri,

Kiani,

Rahimi

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Berberis vulgaris (B. vulgaris or barberry) is a medicinal plant that has been used for various purposes in traditional medicine. Berberine is one of the main alkaloids isolated from B. vulgaris and other plants. Both B. vulgaris and berberine have shown anti‐inflammatory, antioxidant, and immunomodulatory effects in different experimental models and clinical trials. This review aims to summarize the current evidence on the mechanisms and applications of B. vulgaris and berberine in modulating inflammation, oxidative stress, and immune responses. The literature search was performed using PubMed, Scopus, and Google Scholar databases until August 2023. The results indicated that B. vulgaris and berberine could inhibit the production of pro‐inflammatory cytokines, such as tumor necrosis factor‐alpha (TNF‐α), interleukin‐1β (IL‐1β), interleukin 6 (IL‐6), and interleukin‐17 (IL‐17), and enhance the expression of anti‐inflammatory cytokines, such as interleukin 10 (IL‐10) and transforming growth factor‐β (TGF‐β), in various cell types and tissues. B. vulgaris and berberine can also scavenge free radicals, increase antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and reduce lipid peroxidation and DNA damage. B. vulgaris and berberine have been reported to exert beneficial effects in several inflammatory, oxidative, and immune‐related diseases, such as diabetes, obesity, cardiovascular diseases, neurodegenerative diseases, autoimmune diseases, allergic diseases, and infections. However, more studies are needed to elucidate the optimal doses, safety profiles, and potential interactions of B. vulgaris and berberine with other drugs or natural compounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Anti‐inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review

Shakeri,

Kiani,

Rahimi

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Thymoquinone is the active ingredient that possesses the most therapeutic effects. There are many reports of the use of thymoquinone to regulate normal kidney and liver functions [27,28]. In addition, researchers have indicated a decrease in hepatorenal damage in animals under TQ-treatment, regardless of the core etiology [29][30][31].…”

Section: Resultsmentioning

confidence: 99%

Untitled

Ghareeb

2022

J. Med. Chem. Sci.

View full text Add to dashboard Cite

Gold nanoparticles (GNPs) represent the most important applications of nanotechnology in fields of medicine. The study aimed at clarifying their toxic effect, especially upon biochemical parameters related to liver and kidney functions of lab animals. Twenty-four healthy rats were distributed on 4 groups, each containing 6 rats. Control group included rats without any treatment, while GNPs group of mice were under intoxication with gold nanoparticles at a dosage of 50 μl/day for 7 days. As for the GNPs + BS group, intoxicated rats with GNPs were given oil of black seed at a dosage of 10 ml / kg. Finally, BS group included rats were under treatment of 1 ml/ kg of black seed oil. Serum levels of hepato-renal parameters including alanine amino transferase, aspartate amino transferase, alkaline phosphatase, blood urea, creatinine, and uric acid, were measured to detect impaired liver and kidneys functions. Rats treated with GNPs indicated a substantial (P < 0.05) increase in all these biomarkers levels contrasted to the group of control. Then, coadministration of black seed oil together with GNPs had a significant effect on reducing hepatorenal functions disorders. Thus, from these results, it can be concluded that the black seed oil has shown a defensive effect against the disturbances caused by GNPs in the liver and kidney functions of rats.

show abstract

“…4 Additionally, ammonia, a strong free radical producer, results in the generation of free radicals in astrocytes and reduces their ability to fight against free radicals. 5 Increased lipid peroxidation and decreased antioxidant defence have been reported in former studies in the livers and brains of rats with hyperammonemia. 6,7 The animal model of HE utilised to explain the disruption of the normal function of the CNS is thioacetamide (TAA).…”

Section: Introductionmentioning

confidence: 90%

“…A change in pathophysiological circumstances brought about by oxidative stress results in structural and functional disruption of many enzymes and DNA within the cells. 5 Moreover, TAA has been shown to have carcinogenic, neurotoxic, and hepatotoxic effects in a number of animal models. [8][9][10] Although acute HE patients have a significant mortality rate, liver transplantation is the only viable treatment currently available.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Naringenin mitigates thioacetamide-induced hepatic encephalopathy in rats: targeting the JNK/Bax/caspase-8 apoptotic pathway

et al. 2023

View full text Add to dashboard Cite

show abstract

Thymoquinone improves behavioral and biochemical deficits in hepatic encephalopathy induced by thioacetamide in rats

Cited by 16 publications

References 42 publications

Anti‐inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review

Anti‐inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review

Untitled

Naringenin mitigates thioacetamide-induced hepatic encephalopathy in rats: targeting the JNK/Bax/caspase-8 apoptotic pathway

Contact Info

Product

Resources

About