Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies

Bock-Marquette, Ildiko; Maar, Klaudia; Maar, Szabolcs; Lippai, Balint; Faskerti, Gabor; Gallyas, Ferenc; Olson, Eric N.; Srivastava, Deepak

doi:10.1016/j.intimp.2023.109741

Cited by 4 publications

(1 citation statement)

References 80 publications

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“…Transdermal administration of the encapsulated Tβ4 in the ethosomal gels can improve the percutaneous drug absorption and shorten wound recovery [228]. Future prospectives are also attracted to the possible application of Tβ4 in the regeneration of adult tissues such as the heart that was shown in mice where the peptide enhanced myocyte survival and improved cardiac function after coronary artery ligation [229]. For this application the new solutions were developed for Tβ4 delivery.…”

Section: Interesting Example Of Thymosin β4mentioning

confidence: 99%

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Michalicha,

Belcarz,

Giannakoudakis

et al. 2024

Materials

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Effective wound treatment has become one of the most important challenges for healthcare as it continues to be one of the leading causes of death worldwide. Therefore, wound care technologies significantly evolved in order to provide a holistic approach based on various designs of functional wound dressings. Among them, hydrogels have been widely used for wound treatment due to their biocompatibility and similarity to the extracellular matrix. The hydrogel formula offers the control of an optimal wound moisture level due to its ability to absorb excess fluid from the wound or release moisture as needed. Additionally, hydrogels can be successfully integrated with a plethora of biologically active components (e.g., nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing the performance of resulting composite hydrogels in wound healing applications. In this review, the-state-of-the-art discoveries related to stimuli-responsive hydrogel-based dressings have been summarized, taking into account their antimicrobial, anti-inflammatory, antioxidant, and hemostatic properties, as well as other effects (e.g., re-epithelialization, vascularization, and restoration of the tissue) resulting from their use.

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Section: Interesting Example Of Thymosin β4mentioning

confidence: 99%

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Michalicha,

Belcarz,

Giannakoudakis

et al. 2024

Materials

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Novel Approaches in Reversing Environmental Stress Initiated Pathological Processes to Accelerate Organ Repair—The Power of Small Molecules

Bock-Marquette,

Gallyas,

Rendeki

et al. 2024

Advances in Biochemistry in Health and Disease

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Review of Thymic Peptides and Hormones: From Their Properties to Clinical Application

Besman,

Zambrowicz,

Matwiejczyk

2024

Int J Pept Res Ther

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Background The thymus is the main lymphoid organ that regulates the functions of the immune system, protecting against pathogens, tumors, antigens, and mediators of tissue damage. It produces a family of hormone-like peptides that can modulate physiological processes such as stimulation or suppression of immune responses, angiogenesis, and wound healing. Objective This review aims to comprehensively characterize the properties of thymic peptides and their clinical applications. Methodology This article discusses the structure, biological properties, mechanism of action, and therapeutic applications of the most important thymic hormones (thymosin alpha 1, thymosin beta-4, thymulin, and thymopoietin), as well as preparations that are purified thymic extracts. Results Thymic peptides and extracts act in multiple manners on the immune system: they stimulate the differentiation and maturation of T cells, regulate the activity of natural killer cells and dendritic cells, and induce the release of proinflammatory cytokines, and their immunomodulatory effects have been confirmed in numerous clinical studies. An important feature of thymus preparations is their therapeutic safety—even long-term use does not cause side effects. Conclusions A wide range of therapeutic uses, i.e., from defensive and immunomodulatory tasks to participation in tissue regeneration processes, has led to the use of thymic peptides in the treatment of neoplastic diseases, viral infections, autoimmune diseases or immunodeficiencies. Further investigation of the mechanisms of action of thymic peptides may contribute to the discovery of new therapeutic targets.

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Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies

Cited by 4 publications

References 80 publications

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Novel Approaches in Reversing Environmental Stress Initiated Pathological Processes to Accelerate Organ Repair—The Power of Small Molecules

Review of Thymic Peptides and Hormones: From Their Properties to Clinical Application

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