Thyroid abnormalities in paediatric patients with vitiligo: retrospective study

Kartal, Demet; Borlu, Murat; Çınar, Salih Levent; Kesikoğlu, Ayten Ferahbaş; Utaş, Serap

doi:10.5114/ada.2016.60617

Cited by 21 publications

(27 citation statements)

References 17 publications

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“…Uncu et al (29), on the other hand, claim that thyroid disease is associated with the duration of vitiligo, but has nothing to do with the onset and also that the risk of thyroid disease is not increased in segmental type. Similarly, hypothyroidism in adolescence was also common in our study and it was not related to segmental type (12)(13)(14)(15)(16)(17)(18). Ertekin et al (30) Observed 2.10% (in 3 cases) of vitiligo in their series of children with coeliac.…”

Section: Discussionsupporting

confidence: 77%

“…While topical steroids and calcineurin inhibitors have been preferred in younger ages and in limited lesions, while in older ages and in more spread lesions phototherapy and systemic treatment methods have been practised. The age at disease onset has been defined to be between 6.20-8.70 in a number of studies(6)(7)(8)(9)(10)(14)(15)(16)(17). Similarly, the age at disease onset was 9.63 in our study.…”

mentioning

confidence: 58%

“…In our study, covering children only, 18.09 % (19 cases) of iron deficiency anaemia and 5.71% (n=6) vitamin B12 deficiency anaemia have been observed. The ratio of observing thyroid pathology in patients with vitiligo is around 10-26 % (6,14,19,23). In a study conducted by Zetting et al (26) on 1096 adult patients with vitiligo the most common coexisting disease has been reported as thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Demographic Characteristics of Children with Vitiligo: Retrospective Analysis of 105 Cases

Akbaş¹,

Kılınç²,

Aktaş³

2019

Turkish Journal of Pediatric Disease

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Objective: Vitiligo is a disease for which the cause is not clearly known public but is common and is characterised by depigmented macules. It's incidence rate ranges between 0.1-11%. Incidence among children is not known clearly but it has been reported that in half of the cases lesions start before the age of, and in 25% they start before 10-14 years and it has different characteristics than that in adults. The aim of this study is to define the clinical and demographic characteristics of childhood vitiligo, identify the accompanying diseases and the treatment options that are provided. Material and Methods: The files of 105 paediatric patients diagnosed with vitiligo in our hospital's dermatology department during the 2011-2018 period have been retrospectively examined. Age, gender, starting age, disease duration, lesion area, vitiligo type, family vitiligo history, blood tests and accompanying diseases have been recorded. Vitiligo types have been divided into 2 main groups, namely segmental and no segmental. Cases with generalized (vulgar), focal, acral, acrofacial vitiligo have been included in non-segmental vitiligo cases. Results: 44.76% of the patients are female. The average age was 10.98±4.77 years, the average age when the condition started was 9.63±4.53 years and average duration of the disease was 19.19±19,60 months (1.59 years). Number of cases in 0-2 age group was 7 (6.66%), 3-5 age group was 10 (9.52%), 6-11 age group was 32 (30.47%), 12-18 age group was 56 (53.33%). In terms of duration of the disease, 0-2 months included 12 patients (11.42%), 3-6 months included 11 patients (10.47%), 7 months to 1 year included 9 patients (8.57%), and over a year included 73 patients (6.52%). With regards to the types of vitiligo, 6.66% (n=7) had segmental vitiligo, 92.38% (n=97) had non-segmental vitiligo, 0.95% (n=1) had mixed type vitiligo. 53.60% (n=52) of non-segmental vitiligo was focal vitiligo, 31.95% (n=31) was vitiligo vulgaris 7.21% (n=7) was acrofacial and 7.21% (n=7) was acral type. In terms of focal vitiligo 40.38% (n=21) had cheek involvement, 23.07% (n=12) periorbital involvement, 11.53% (n=6) perioral involvement, 7.69% (n=4) genital involvement and five cases (9.61%) had multiple involvements. In 30.4% of the cases (n=32), one or more coexisting disease has been observed to exist. Treatment options differed by age. While topical steroids and calcineurin inhibitors have been preferred in younger ages and in limited lesions, while in older ages and in more spread lesions phototherapy and systemic treatment methods have been practised. Conclusion: This study is addressing the clinical and demographic characteristics of children with vitiligo as well as the practised treatment options. In contrast to other studies, this study has concluded more incidences among males. Regarding people in the early stages of vitiligo and in lesions localised in head-neck area, micro-therapy has been observed to be effective and calcineurin inhibitors have hastened repigmentation.

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Section: Discussionsupporting

confidence: 77%

mentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

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Clinical and Demographic Characteristics of Children with Vitiligo: Retrospective Analysis of 105 Cases

Akbaş¹,

Kılınç²,

Aktaş³

2019

Turkish Journal of Pediatric Disease

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“…The exact pathogenesis of vitiligo is uncertain [ 4 ]. Vitiligo is a multifactorial disorder related to both genetic and non-genetic factors [ 5 , 6 ]. It is generally agreed that there is an absence of functional melanocytes in the vitiligo skin and that this loss of histochemically recognizable melanocytes is a result of their destruction [ 4 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the serum zinc level in patients with vitiligo

Mogaddam

Ardabili

Maleki

et al. 2017

pdia

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IntroductionVitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches, which affects approximately 0.1–2% of the general population worldwide. Zinc is an essential trace element that is necessary for growth and development at all stages of life. Some studies have reported an association between serum zinc levels and vitiligo.AimTo measure the serum zinc level in patients with vitiligo compared to healthy subjects.Material and methodsOne hundred patients with vitiligo and 100 healthy controls were referred to our clinic. The two groups were matched for age and sex. Atomic absorption spectrophotometry was used to measure serum zinc levels. The statistical analysis was performed using SPSS software.ResultsThe mean serum level of zinc in vitiligo patients and controls was 80.11 ±17.10 μg/dl and 96.10 ±16.16 μg/dl, respectively. The serum zinc level in patients with vitiligo was significantly lower than in healthy controls (p = 0.0001).ConclusionsThe results of our study revealed a significant association between vitiligo and serum zinc levels. A relative decrease in the serum zinc level in vitiligo patients can highlight the role of zinc in the pathogenesis of vitiligo, and large-scale studies need to be conducted to confirm these findings and assess the effect of oral zinc supplements in patients with low zinc levels.

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“…Thyroid disorders are the most common co-morbidity in patients with NSV, hypothyroidism being more common and the incidence being as high as 13%-22% in children with vitiligo. (23,24) Since vitiligo usually precedes the development of thyroid dysfunction, and since thyroid dysfunction can be subclinical, annual thyroid screening with the thyroid autoantibodies TSH, T3, and T4 is suggested for children with vitiligo, especially for those with non-segmental disease. (25) However, some studies suggest that the incidence of allergic diseases and atopic diathesis is even more common in children with vitiligo than thyroid abnormalities.…”

Section: Clinical Featuresmentioning

confidence: 99%

Pediatric Vitiligo

Sharma¹

2019

jmscr

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Thyroid abnormalities in paediatric patients with vitiligo: retrospective study

Cited by 21 publications

References 17 publications

Clinical and Demographic Characteristics of Children with Vitiligo: Retrospective Analysis of 105 Cases

Clinical and Demographic Characteristics of Children with Vitiligo: Retrospective Analysis of 105 Cases

Evaluation of the serum zinc level in patients with vitiligo

Pediatric Vitiligo

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