Thyroid carcinoma in Pakistan

Bukhari, Uzma; Sadiq, Saleem; Memon, Jawaid Hussin; Baig, Farooq

doi:10.1016/s1658-3876(09)50023-4

Cited by 11 publications

(8 citation statements)

References 15 publications

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“…It seems we are still following a conservative approach with total thyroidectomy in 81% of participants and another 16.9% underwent two surgeries with initial lobectomy followed by total thyroidectomy. The prevalence of papillary carcinoma in our study is comparable to previous studies done in Pakistan and with the international data 11…”

Section: Discussionsupporting

confidence: 91%

Pre-operative serum TSH levels: A risk factor for advanced metastatic differentiated thyroid carcinoma

et al. 2019

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Background and Objective: As the thyroid cancer incidence is increasing, the search for its risk factor is becoming more important. Serum thyroid stimulating hormone (TSH) levels being a growth factor for normal thyroid tissue, is also considered as growth promotor of cancer cells. In our study we aimed for pre-operative serum TSH levels of Differentiated thyroid cancers (DTC) done before their first surgery and determined its association with advanced disease in terms of stage, multifocal disease, lymph node involvement and distant metastasis. Methods: We have conducted a retrospective review of thyroid cancers from 1st January 2008 to 31st December 2017. Out of 281, 142 cases were included according to inclusion criteria. We noted the demographic details of participants, their histopathological diagnosis and serum TSH levels done before first surgery from the medical records. We calculated the stage of tumor through modified American Joint Committee (AJCC) staging system. Results: Out of 147 participants, 89.4% had papillary carcinoma or its variants whereas 10.6% reported follicular carcinoma. The mean pre-op TSH level of the patients included was 2.04 ± 1.79. In addition to the descriptive analysis, the univariate regression analysis revealed that the association of serum TSH levels was found to be statistically insignificant with advanced stage of thyroid cancer, multifocal disease, lymph node metastasis and distant metastasis respectively. Conclusion: The serum TSH levels before surgery was not associated with poor prognosis of differentiated thyroid cancer with respect to higher staging, multifocal disease, lymphatic or distant metastasis. doi: https://doi.org/10.12669/pjms.35.5.704 How to cite this:Batool S, Afridi MS, Khoja A, Islam N. Pre-operative serum TSH levels: A risk factor for advanced metastatic differentiated thyroid carcinoma. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.704 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 91%

Pre-operative serum TSH levels: A risk factor for advanced metastatic differentiated thyroid carcinoma

et al. 2019

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“…Most frequent malignancy of thyroid gland is thyroid cancer which has most increasing trend in Pakistan and throughout the world [1]. The incidence of thyroid cancer in Pakistan is 1.2% of all malignancies consisting of papillary thyroid carcinoma 69–71%, follicular thyroid carcinoma 11–13%, medullary thyroid carcinoma 3–5% and anaplastic thyroid carcinoma 1–2% [2].…”

Section: Introductionmentioning

confidence: 99%

Interaction among susceptibility genotypes of PARP1 SNPs in thyroid carcinoma

et al. 2018

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Polymorphisms in DNA repair genes may alter the repair mechanism which makes the person susceptible to DNA damage. Polymorphic variants in these DNA repair pathway genes such as Poly (ADP-ribose) polymerase- 1 (PARP1) have been associated with susceptibility of several types of cancer including thyroid. Many studies have been published on PARP1 gene polymorphisms and carcinogenesis with inconsistent results. The present study was designed to explore the link between the PARP1 polymorphisms and thyroid cancer risk. This case-control study was comprised of 456 thyroid cancer patients and 400 healthy controls. Three SNPs of PARP1 gene; rs1136410, rs1805414 and rs1805404 were analyzed using ARMS-PCR. The combined genotype and haplotype analysis were performed using haploview software 4.2. Major allele homozygote (CC) of rs1136410 and combined genotype (TT+TC) of rs180414 showed a significant association with thyroid cancer risk (OR = 1.30; 95% CI 0.99–1.77; P = 0.05) and (OR = 0.43; 95% CI = 0.27–0.67; P = 0.03). Histological subtype analysis showed the significant association of selected PARP1 SNPs with papillary, follicular and anaplastic subtypes in thyroid cancer patients. Haplotype analysis showed that TCT (p = 0.01), CTT (p = 0.02) and CTC (p = 0.03) were significantly higher in controls when compared to cases. However, TTC (p = 0.05) and TCC (p = 0.01) haplotype frequency was significantly higher in cases compared to controls. Global haplotype analysis showed that there was an overall significant difference between cases and controls (p = 0.001). Identification of these genetic risk markers may provide evidence for exploring insight into mechanisms of pathogenesis and subsequently aid in developing novel therapeutic strategies for thyroid cancer.

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“…Thyroid cancer is the most frequent malignancy of thyroid gland and the most increasing endocrine cancer in Pakistan and globally [1]. Its increasing incidence is the main reason for considerable attention of recent researches [2].…”

Section: Introductionmentioning

confidence: 99%

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

Sarwar¹,

Mahjabeen²,

Bashir³

et al. 2017

Cell Physiol Biochem

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Background/Aims: In mammalian cells, XRCC3 plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to thyroid cancer. In this study, we used a haplotype-based approach to investigate whether 5 selected SNPs i.e. rs1799796, rs1799794, rs861539, rs709399 and rs861530 of XRCC3 gene are associated with thyroid cancer risk in 456 cancer patients and 400 cancer-free controls. Methods: Genotyping was performed using Allele-specific PCR followed by sequencing. Statistical analysis was performed to analyse gene and haplotype association. Results: After analysis, frequency of mutant genotype/alleles of SNPs (rs1799796, p<0.0001; rs1799794, p<0.0001; rs861539, p<0.001; rs709399, p <0.0001; rs861530, p<0.002) was found significantly higher in thyroid cancer patients compared to controls. Significant associations were found for most of the variant genotypes in SNPs of rs1799794, rs1799796, rs861539, rs861530 and rs709399 in papillary thyroid and follicular cancer patients compared to other histologic subtypes of thyroid carcinoma. Additionally, haplotype analysis revealed that haplotypes, AACGA (p= 0.0005), AGTAA (p= 0.008), GATAA (p= 0.001), GGCAA (p= 0.001) were linked with significant increase in thyroid cancer risk. However, haplotype AGCGG (p= 0.0009) was associated with a significant reduced thyroid cancer risk. Conclusion: Our results suggest that common genetic variants in the XRCC3 gene of DSBR pathway may modulate thyroid cancer risk.

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Thyroid carcinoma in Pakistan

Cited by 11 publications

References 15 publications

Pre-operative serum TSH levels: A risk factor for advanced metastatic differentiated thyroid carcinoma

Pre-operative serum TSH levels: A risk factor for advanced metastatic differentiated thyroid carcinoma

Interaction among susceptibility genotypes of PARP1 SNPs in thyroid carcinoma

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

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