Thyroid dysfunction and inflammatory biomarkers in chronic obstructive pulmonary disease: Relation to severity and exacerbation

Background: Hormones also take part in respiratory control via peripheral chemo receptors or by their local effects on the lungs and the airways. In chronic obstructive pulmonary disease patients, respiratory muscles are required to work efficiently than normal individuals to establish a sufficient respiration. Changes in serum hormone levels of COPD patients adversely affect functioning of respiratory muscles. Objective of the study was to assess endocrinal profile in COPD patient with comparable control groups.Methods: A Hospital based Case control study conducted at Department of Pulmonary Medicine, Late B.R.K.M Government Medical College, Jagdalpur, Chhattisgarh, India during July 2016 to January 2017. Study included 75 diagnosed cases of COPD in which moderate, severe, very severe COPD was 25 in each of this group (per GOLD ‘s guideline) and compared to age matched 25 healthy control.Results: In this study serum growth hormone and serum testosterone showed significant difference between COPD cases and control group and fair significant difference in serum FSH between COPD cases and control groups. There was no significant correlation between serum growth hormone, serum testosterone and serum FSH with COPD grading. There was no statistically difference observed in serum LH (p=0.425) level between COPD cases and control groups. Present study showed there was statistically difference in FT3, FT4 and TSH level between COPD cases and control groups. There was significant negative correlation between FT4 levels between COPD grading. But no correlation seen between COPD grading and control with respect to serum FT3 and TSH level.Conclusions: Endocrinal assessment in present study showed significant decrease in serum growth hormone and serum testosterone in COPD patients, which are anabolic hormones. Early detection and correction of such an anabolic hormonal abnormality may prevent skeletal and diaphragmatic muscle weakness, and improve respiratory drive of COPD patients.

show abstract

“…18 In agreement to our results, a recent study by Amira Shoukry et al and Dimopoulou et al also observed similar findings. 19,20…”

Section: Discussionmentioning

confidence: 99%

Endocrinal assessment of chronic obstructive pulmonary disease patients as compared to control groups

et al. 2017

View full text Add to dashboard Cite

show abstract

“…However, they did not reveal any significant relationship between thyroid functions and arterial blood gas parameters in patients with AECOPD. 20 Karadağ et al detected a positive correlation between PaO 2 and fT4. 18 In a study conducted with 30 AECOPD patients, Madhuri G. et al did not find any significant relationship between fT3-fT4-TSH and PaO 2 , PaCO 2 , and SaO 2 .…”

Section: F I G U R E 1 Numbers Of Non-thyroidalmentioning

confidence: 96%

Prevalence of non‐thyroidal illness syndrome in COPD exacerbation and effect of hypoxaemia and hypercapnia on thyroid functions

Gümüş

Özyurt

Özçelik

et al. 2020

Clinical Respiratory J

View full text Add to dashboard Cite

Introduction Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease showing acute exacerbations during its course. Comorbidities often accompany. Non‐thyroidal illness syndrome (NTIS) occurs because of the functional impairment in the hypothalamic‐pituitary‐thyroid axis in severe critical cases. The objective of the current study is to determine the prevalence of NTIS among hospitalised patients due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and to reveal the factors affecting thyroid functions. Materials and methods A total of 132 patients hospitalised for AECOPD were enroled. Arterial blood gas samples at room air and venous blood samples for thyroid function tests were obtained within 24 hours following hospitalisation. Results The mean age was 69.3 ± 9.6 years with male predominance (M/F:130/2). The prevalence of NTIS was 55%. Subgroups of NTIS cases were analysed. Low TSH levels were the most common pathology (55%). Patients with NTIS had significantly lower PaO2 and SaO2 levels compared with those without NTIS (P = 0.045 and P = 0.022, respectively). In addition, a positive correlation was found between PaO2 and free thyroxine (fT4) (P < 0.001, r = 0.313). A statistically significant negative correlation between PaCO2 and fT4 was found (P < 0.001, r = −0.393). And a statistically significant negative correlation between PaCO2 and free triiodothyronine (fT3) values were found (P = 0.040, r = −0.183). Conclusion NTIS is a very common condition during AECOPD. We believe that hypoxemia causing functional impairment in the hypothalamic‐pituitary‐thyroid axis is the main mechanism in NTIS development and hypercapnia disrupts freeT3 and freeT4 production and secretion.

show abstract

“…Однако интерпретация этих данных и оценка возможностей их использования встречают у нас затруднения. При этом полученные данные, указывающие на повышенный оксидативный стресс в условиях низкой Т3-ХОБЛ и, вероятно, необходимость в модуляции антиоксидантной системы, возможно, в данном случае заслуживают внимания [ 52 ]. Наряду с этим установлена обратная корреляция между уровнем общего Т3 и тяжестью заболевания, степенью гипоксемии и медиаторами провоспаления.…”

Section: роль контринсулярных гормонов в нарушении гомеостаза глюкозы...unclassified

The role of counterinsular hormones in the regulation of glucose homeostasis and the pathogenesis of type 2 diabetes mellitus in COPD

Kobylyansky¹

2021

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

The frequent combination of type 2 diabetes mellitus (T2DM) and chronic obstructive pulmonary disease (COPD) is an important socially significant and far from being studied problem. However, only a few works are devoted to it. To solve this problem, we analyzed the possible pathogenetic mechanisms from the standpoint of the impact on glucose homeostasis of the main hormones — insular and contrainsular.The analysis was carried out using various literature databases, including Index Medicus, Scopus, Pub Med, Embase, Cochrane and others for the period, with rare exceptions, for 2000–2020, of which the works devoted directly to the aspect considered in this work were published in the last 5 years.The analysis revealed a mutual aggravating effect of COPD and T2DM, in which COPD plays an initiating role. It also revealed a significant role of counterinsular hormones, which largely determines the nature of the pathogenesis of T2DM in COPD.In addition, the article draws attention to the possible role of genetic factors that can be common for COPD and T2DM and have a significant role in the comorbidity of COPD and T2DM. The data obtained can be used for both diagnostic and therapeutic purposes in the correction of disorders of carbohydrate metabolism in COPD, which is the lot of further research.

show abstract

Thyroid dysfunction and inflammatory biomarkers in chronic obstructive pulmonary disease: Relation to severity and exacerbation

Cited by 7 publications

References 30 publications

Endocrinal assessment of chronic obstructive pulmonary disease patients as compared to control groups

Endocrinal assessment of chronic obstructive pulmonary disease patients as compared to control groups

Prevalence of non‐thyroidal illness syndrome in COPD exacerbation and effect of hypoxaemia and hypercapnia on thyroid functions

The role of counterinsular hormones in the regulation of glucose homeostasis and the pathogenesis of type 2 diabetes mellitus in COPD

Contact Info

Product

Resources

About