Thyroid Dysfunction in Patients with Liver Cirrhosi

Joeimon, J L; Mohanraj, Karthik Ganesh; Karthikeyan, R; T, Rajkumar Solomon; Aravind, A.; K, Caroline Selvi; Balamurali, R.; Ramkumar, G.; Muthukumuran, K; C, Vaishnavipriyaa; Kavitha, S.; Anand, Aravindh Sivanandan

doi:10.9790/0853-1604081822

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…And this may have an impact on the endurance of the patients. Neglect of these may result in over of under diagnosis of liver or thyroid diseases and thereby cause problems in patient care 12 .…”

Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction in Patient with Cirrhotic Liver Disease and its Relation to the Severity of Cirrhosis

2023

PJMHS

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Background: Liver carries its vital significance due to ability to control over excretion, metabolism and transportation of the thyroid hormone. Peripheral change of T4 to T3 occurs in the live leading to initiation of action and breakdown of the hormones. Any morbidity in the liver can result in the decrease in TSH level and leading to thyroid dysfunction. So it is necessary to determine this impact in cases with liver cirrhosis. Methodology: 115 cases of chronic liver disease who were not on the any therapy were involved in this research. The age of >18 years and both genders were selected. Data was collected from Department of Medicine, Lahore General Hospital, and Lahore in a duration of one year. All the demographics and baseline information mandatory for the selection of the appropriate sample was recorded. The participants were informed about the purpose of the research and after their consent they were selected for this study. Finally, the collected data was analyzed using SPSS 23.inc. Practical implication: Thyroid dysfunction in patients with cirrhotic liver disease has practical implications for their management and outcomes. Regular screening and early intervention are important to detect and treat thyroid dysfunction promptly. Managing both cirrhosis and thyroid dysfunction requires a multidisciplinary approach involving hepatologists and endocrinologists. Patient education and support are crucial for raising awareness and ensuring adherence to treatment plans. Further research is needed to understand the relationship between thyroid dysfunction and cirrhosis severity and to explore potential therapeutic targets. Integrating thyroid evaluation into the overall management of cirrhosis can improve patient outcomes and quality of life. Results: Mean age of 51(9.81) years were involved in this research. The male cases were higher in number 81(70.4%). The body mass index value was 27.5(3.65). Child Pugh A class was noted in 37(32.2%), B in 32(27.8%) & C in 46(40%). Serum T3 level was 2.05, serum T4 level was 8.69, serum FT3 level was 3.06, serum FT4 was 1.24 and TSH level was having a mean value 3.15. A significant inverse relationship noted in the severity of cirrhosis and thyroid profile levels. Conclusion: Thyroid function depends on the smooth functioning of the liver through its hormones. As the liver compromise some disease, this normal function disturbs and thyroid dysfunction occurs which increase with the harshness of liver disease. Keywords: Liver Disease, Thyroid Dysfunction, HCV, TSH

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Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction in Patient with Cirrhotic Liver Disease and its Relation to the Severity of Cirrhosis

2023

PJMHS

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A Cross-Sectional Study of Thyroid Dysfunction in Patients Suffering from Liver Cirrhosis in a Tertiary Care Hospital in Bengaluru, India

Kalmani¹,

H.S²,

Ravishankar³

et al. 2021

jebmh

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BACKGROUND Thyroid abnormalities are seen in most of the patients suffering from liver cirrhosis. Cirrhosis of the liver is the major cause of morbidity and mortality worldwide. Cirrhosis plays a vital role in the thyroid hormone metabolism and thyroid hormone circulation by producing thyroid binding globulin. Hence, it is seen that the thyroid dysfunction is associated with the severity of liver disease. We wanted to study the changes in the levels of thyroid hormones in patients suffering from alcoholic liver cirrhosis. METHODS In this cross-sectional study, 50 patients who were admitted to the IP department and ICU of General Medicine Department of Akash Hospital, Devanahalli, for symptoms of cirrhosis of liver were evaluated for their thyroid profile along with other relevant investigations. RESULTS Among the 50 patients studied, 43 were male and 7 were female. 17 patients had an increase in their thyroid stimulating hormone (TSH). These patients also had a significant association with various LFT parameters such as indirect bilirubin, AST, ALT, APS, and GGT. These 17 patients who had increase in TSH also had associated hepatic complications such as - jaundice (41 %), hepatic encephalopathy (35.29 %), bleeding varices (29.4 %), and portal hypertension (82.35 %). CONCLUSIONS Thyroid abnormalities are not uncommon in patients with cirrhosis. Hypothyroidism is the most common abnormality that was detected. Rate of complications is also high in patients with elevated levels of TSH. A fair amount of suspicion is required for detecting thyroid abnormalities in patients suffering from cirrhosis. KEYWORDS Cirrhosis, Thyroid Hormone, Hypothyroidism, Hyperthyroidism, Thyroiditis

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Prevalence of Thyroid Dysfunction in Chronic Liver Disease

Desai

Haideri

Basu

et al. 2021

Global Journal for Research Analysis

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Introduction: Chronic Liver Disease affects most of the organs in the human body. Various studies have been done regarding chronic liver disease, but not many studies are done on the assessment of thyroid function in chronic liver disease. Present study thus aimed at assessing the thyroid functions in chronic liver disease patients. Materials & Methods: A hospital based cross-sectional study was conducted at a tertiary care hospital Study included 52 patients presenting with Chronic liver disease fullling the study criteria using purposive conservative sampling. Detailed examination was done for all cases including thyroid function tests. All analysis was carried out by using SPSS software version 21. Overall prevalence of thyroid dysfunction among chronic liver disease patients was 36.5%. A Results: signicant positive correlation was observed between severity of chronic liver disease and TSH levels (r-0.60) while an inverse correlation was observed with T3 and T4 levels (p<0.01). A signicant association was observed between presence of thyroid dysfunction among chronic liver disease patients who had hepatic encephalopathy (66.7% vs 32.6%; p<0.05). Also, a signicant association was observed with severity of chronic liver disease. Present study observed Conclusion: that derangement in thyroid prole is common in patients with cirrhosis of liver. A statistically signicant change was observed in serum T3 and T4 levels that tend to fall with progressive severity of chronic liver disease irrespective of aetiology. Thus all cirrhotic patients should undergo thyroid function evaluation as these patients are denitely associated with development of thyroid dysfunction.

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Thyroid Dysfunction in Patients with Liver Cirrhosi

Cited by 5 publications

References 2 publications

Thyroid Dysfunction in Patient with Cirrhotic Liver Disease and its Relation to the Severity of Cirrhosis

Thyroid Dysfunction in Patient with Cirrhotic Liver Disease and its Relation to the Severity of Cirrhosis

A Cross-Sectional Study of Thyroid Dysfunction in Patients Suffering from Liver Cirrhosis in a Tertiary Care Hospital in Bengaluru, India

Prevalence of Thyroid Dysfunction in Chronic Liver Disease

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