Thyroid Eye Disease

Cockerham, Kimberly P.; Chan, Stephanie S.

doi:10.1016/j.ncl.2010.03.010

Cited by 24 publications

(14 citation statements)

References 177 publications

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“…Based on current knowledge, a strong causal association with autoimmunity has been established. Autoimmune conditions frequently reported with OP include Crohn's disease [10], rheumatoid arthritis, systemic lupus erythematosus [11], Myasthenia gravis [12], Wegener's granulomatosis [13], sarcoidosis [14], Grave's disease [15], ulcerative colitis, Tolosa-Hunt syndrome [16], and ankylosing spondylitis. Infectious agents have not been implicated although there are cases of OP reported a few weeks post Group A strep pharyngitis or upper respiratory infections suggesting their possible role [17].…”

Section: Pathophysiologymentioning

confidence: 99%

Orbital Pseudotumor: A Mimic of Orbital Cellulitis

Natesan¹,

Twardy²

2018

Microbiol Infect Dis

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Orbital pseudotumor (OP) also referred to as Non-specific orbital inflammatory syndrome (NOIS) has been associated with a wide range of inflammatory and autoimmune disorders and the exact etiology of this syndrome remains unknown. The differentiation of orbital cellulitis (OC) from OP is often complex leading to delays in appropriate treatment. Timely decision is crucial as both conditions are associated with intracranial complications and result in loss of vision. As compared to the few cases reported in literature, our case is unusual due to a history of mild chronic, relapsing-remitting course for over a year, without a clear diagnosis. Diagnosis is by exclusion, based on a thorough history, clinical presentation, and rapid response to corticosteroid treatment. It mimics orbital cellulitis or malignant lymphoma of the orbit because of the overlapping clinical manifestations. Our case emphasizes the importance of including this entity in the differential diagnosis of orbital cellulitis and the need for timely diagnosis and treatment to halt the progression of disease. This article provides a brief overview of OP, critical nature of the condition, clinical clues to diagnosis, and novel treatment options (steroid sparing agents) currently available for this condition. OP and NOIS are used interchangeably in this document.

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Section: Pathophysiologymentioning

confidence: 99%

Orbital Pseudotumor: A Mimic of Orbital Cellulitis

Natesan¹,

Twardy²

2018

Microbiol Infect Dis

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“…La oftalmopatía tiroidea presenta una incidencia ajustada anual de 16 mujeres y 3 hombres por 100 000 habitantes, con el pico de incidencia en la cuarta y quinta décadas, aunque también se puede presentar en niños y ancianos 3,8 .…”

Section: Epidemiologíaunclassified

“…La Escala Clínica de Actividad modificada, CAS por sus siglas en inglés, constituye la escala de evaluación más frecuentemente utilizada en la orbitopatía tiroidea. Esta asigna un punto a cada síntoma y signo presente (dolor retrobulbar, dolor evocado ante la fijación de la mirada, eritema palpebral, inyección conjuntival, quemosis, inflamación de la carúncula y edema palpebral) 8 .…”

Section: Evaluaciónunclassified

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Adulto eutiroideo con oftalmopatía de Graves unilateral: reporte de caso y revisión de tema

Murillo

Salas

2016

RC_UCR-HSJD

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La oftalmopatía tiroidea o de Graves es una con-dición que afecta la órbita, en la cual la reacción inmune a un autoantígeno, probablemente el re-ceptor de TSH, provoca una reacción inflamatoria en los músculos extraoculares y el tejido orbita-rio1. Sólo un pequeño porcentaje de los pacientes con oftalmopatía presenta una condición eutiroi-dea y un porcentaje aún menor, afección unilateral o asimétrica. La historia natural de la oftalmopa-tía unilateral es desconocida2. Presentamos el re-porte de caso y revisión de tema de un paciente eutiroideo con oftalmopatía tiroidea unilateral

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“…Graves' Ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy, is an autoimmune disease characterized by invasion of retrobulbar and orbital tissues [1, 2]. About 20–50% of GO patients also present clinically with Graves' Disease (GD), which is characterized by diffuse goiter with hyperthyroidism [3–5].…”

Section: Introductionmentioning

confidence: 99%

Pingmu Decoction Induces Orbital Preadipocytes Apoptosis In Vitro

Zhang

Gao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Pingmu Decoction is the Traditional Chinese Medicine which has treated Graves' Ophthalmopathy (GO) in the inactive stage for more than ten years. This study was to explore the mechanism of Pingmu Decoction of inhibiting preadipocytes in GO patients from differentiating into mature adipocytes. Human orbital preadipocytes were isolated and cultured through tissue explant method. Orbital preadipocytes were induced into mature adipocytes. The medicinal serum was prepared from rats. The cells were treated with medicinal serum which were divided into three groups, low dose group (5%), medium dose group (10%), and high dose group (20%). The cells viabilities were observed by Oil Red O staining, MTT method, and Annexin V/propidium iodide (PI) double staining. Effect of Pingmu Decoction on cell apoptosis rate of orbital matured adipocytes was measured by flow cytometry. The genes Fas and Fas L from cell groups were tested by RT-PCR and Western blotting. The expression of master adipogenic transcription factors, including peroxisome proliferation-activity receptor (PPAR) γ and CCAAT/enhancer binding protein (C/EBP) α, was tested by Western blotting. Pingmu Decoction could reduce orbital preadipocytes viability and induce apoptosis of mature adipocyte via Fas/Fas L signaling pathway. Pingmu Decoction reduced lipid accumulation and downregulated the expression of PPAR γ and C/EBP α. Pingmu Decoction may play a therapeutic effect by reducing the accumulation of orbital adipocytes.

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Thyroid Eye Disease

Cited by 24 publications

References 177 publications

Orbital Pseudotumor: A Mimic of Orbital Cellulitis

Orbital Pseudotumor: A Mimic of Orbital Cellulitis

Adulto eutiroideo con oftalmopatía de Graves unilateral: reporte de caso y revisión de tema

Pingmu Decoction Induces Orbital Preadipocytes Apoptosis In Vitro

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