Thyroid FNA biopsies comprised of abundant, mature squamous cells can be reported as benign: A cytologic study of 18 patients with clinical correlation

Chen, Athena L.; Renshaw, Andrew A.; Faquin, William C.; Alexander, Erik K.; Heller, Howard T.; Cibas, Edmund S.

doi:10.1002/cncy.21976

Cited by 8 publications

(9 citation statements)

References 23 publications

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“…TBSRTC is constantly evolving, as evidenced by the several modifications introduced in the second edition of TBSRTC 8 . Future revisions may consider amending the adequacy criteria to include squamous‐derived lesions 9,10 . Although rare, thyroid‐related lesions comprising squamous cells do exist.…”

Section: Discussionmentioning

confidence: 99%

“…Although rare, thyroid‐related lesions comprising squamous cells do exist. Intrathyroidal sources of benign squamous cells include cysts derived from developmental rests or remnants, as well as dermoid or epidermoid cysts 9,10 . Some authors have suggested that including these lesions with benign squamous cells into the Bethesda II category, even in the absence of thyroid follicular cells or colloid, would be reasonable 8–10 .…”

Section: Discussionmentioning

confidence: 99%

“… 8 Future revisions may consider amending the adequacy criteria to include squamous‐derived lesions. 9 , 10 Although rare, thyroid‐related lesions comprising squamous cells do exist. Intrathyroidal sources of benign squamous cells include cysts derived from developmental rests or remnants, as well as dermoid or epidermoid cysts.…”

Section: Discussionmentioning

confidence: 99%

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A Killian‐Jamieson diverticulum potentially mimicking a thyroid nodule: A case report highlighting the cytology of a pharyngoesophageal diverticulum

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Killian‐Jamieson diverticulum potentially mimicking a thyroid nodule: A case report highlighting the cytology of a pharyngoesophageal diverticulum

et al. 2022

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“…The cyst-lining cells are follicular cells that have undergone reactive changes including spindle- or elongated-shaped morphology, large round to oval nuclei with distinct nucleoli, fine chromatin, smooth nuclear contour, distinct cytoplasmic borders, and occasional exaggerated unipolar/bipolar cytoplasmic processes [3, 4]. Rarely, aspirates from the FNA may exclusively consist of benign-appearing, mature squamous cells [5]. It is worth noting that about 10–15% of thyroid nodules represent malignancy [6].…”

Section: Anterior Neckmentioning

confidence: 99%

Head and Neck Cystic Lesions: A Cytology Review of Common and Uncommon Entities

et al. 2022

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Background: Cystic lesions of the head and neck are a diagnostic challenge since they are seen in the clinical presentation of a wide variety of conditions. Herein, common and uncommon entities that present as cystic lesions in the head and neck are reviewed. Summary: In this study, peer-reviewed articles were selected using the database PubMed, Google, Google Scholar, and Scopus. Emphasis was placed on peer-reviewed articles that discuss the cytomorphology and differential diagnosis of entities that present as cystic lesions of the head and neck. In the anterior neck, both benign and malignant neoplasms can present, including papillary thyroid carcinoma (PTC), thyroid adenomatoid nodule, parathyroid cysts, and thyroglossal cysts. In the lateral neck, branchial cleft cyst, PTC, ectopic thyroid cyst, and squamous cell carcinomas (human papilloma virus and non- human papilloma virus-related) are common. Age over 40 years raises the possibility of malignancy. In the deep neck, mostly benign cystic entities occur such as a pleomorphic adenoma, paraganglioma, schwannoma, branchial cyst, epidermal inclusion cyst, and lymphoepithelial cyst. Lesions with squamous cell features can pose diagnostic dilemmas. Conclusion: Cytologic examination of head and neck cysts can provide valuable information regarding the nature of the cystic lesions. Information about anatomic site and clinical history can assist with the differential diagnoses. Ancillary studies can improve the diagnosis in some cases. Each case should be evaluated very carefully since there are a wide variety of congenital conditions, infectious/inflammatory conditions, benign neoplasms, and primary and secondary malignancies presenting as a cystic mass in the head and neck.

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“…The presence of ciliated cells, lymphocytes, squamous, colloid, and keratin are useful for the differential diagnosis. [50][51][52][53][54][55][56][57] The presence of a water-clear fluid mostly suggests parathyroid cysts, although a yellowish to brown cystic material is seen in thyroid cysts/pseudocysts. To note, occasionally PTC can be diagnosed in thyroglossal duct cysts.…”

Section: Other Cystic Lesionsmentioning

confidence: 99%

Approach to FNA of Thyroid Gland Cysts

Rossi¹,

Tralongo²,

Fiorentino³

et al. 2022

Advances in Anatomic Pathology

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Fine needle aspiration is a well-known procedure for the diagnosis and management of thyroid lesions, representing the first diagnostic tool for the definition of their nature. In clinical practice, a thyroid nodule can be classified as solid, cystic, and partially cystic based on its internal components. Different thyroid imaging reporting systems and cytologic diagnostic systems have focused their attention on solid nodules, which are more frequently linked with a malignant outcome. In fact, numerous papers demonstrated that nodules with microcalcifications, a taller-than-wide shape, hypoechogeneity, and irregular margins, are more likely to be malignant on histology. Nevertheless, according to the literature, the risk of malignancy in a partially cystic thyroid nodule ranges between 3.3 and 17-5%, including, for instance, the possible diagnosis of a cystic papillary thyroid carcinoma and other malignant entities. Therefore, in the current review article, we are going to discuss the approach to thyroid cystic lesions on fine needle aspiration cytology.

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Thyroid FNA biopsies comprised of abundant, mature squamous cells can be reported as benign: A cytologic study of 18 patients with clinical correlation

Abstract: The findings of the current study suggest that thyroid FNA specimens comprised almost exclusively of mature squamous cells can be reported as benign. Cancer Cytopathol 2018;126:336-41. © 2018 American Cancer Society.

Cited by 8 publications

References 23 publications

A Killian‐Jamieson diverticulum potentially mimicking a thyroid nodule: A case report highlighting the cytology of a pharyngoesophageal diverticulum

A Killian‐Jamieson diverticulum potentially mimicking a thyroid nodule: A case report highlighting the cytology of a pharyngoesophageal diverticulum

Head and Neck Cystic Lesions: A Cytology Review of Common and Uncommon Entities

Approach to FNA of Thyroid Gland Cysts

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