Thyroid Follicle Transplantation by Percutaneous Injection

Iwai, Hiroshi; Yamashita, Toshio; Kubo, Nobuo; Tomoda, Koichi; Tsujikawa, Satoshi; Inaba, Muneo; Ikehara, Susumu; Kumazawa, Tadami

doi:10.3109/00016489309126197

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…It seems that there is a “latent period” between thyroidectomy and initiation of the function of the autograft, which may be necessary for the vascular supply of the autograft from the surrounding tissues. During this period, a transient hypothyroidism can develop 23, 32, 36–39…”

Section: Discussionmentioning

confidence: 99%

Functional capacity of the thyroid autograft and heterograft: An experimental study

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Functional capacity of the thyroid autograft and heterograft: An experimental study

et al. 2011

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“…Studies on animals have been collected in Table 1 comprising 22 publications. Studies were clustered according to their geographical distribution, half of which were published by US and European research groups [ 18 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 67 ] ( Figure 6 ), while the animals enrolled in the studies were mostly murine and canine [ 28 , 29 , 30 , 31 , 33 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 67 , 68 ], among which only one study discussed orthotopic autotransplantation into the remaining thyroid lobe [ 33 ]. In all the other concerned heterotopic autotransplantations, the preferred site was the muscle (posterior limb, neck, and dorsal-abdominal region) [ 18 , 32 , 36 , 37 , 38 , 41 , 42 , 43 , 44 , 68 ].…”

Section: Resultsmentioning

confidence: 99%

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Spinelli,

Ghionzoli,

Sahli

et al. 2024

Cancers

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Background and aims: This paper aims to study an alternative solution to hormonal replacement therapy in specific groups of patients who underwent thyroidectomy during childhood or adulthood. After cryopreservation, thyroid autotransplantation could be an alternative solution which would allow us to use the ability of the thyroid tissue of producing hormones according to the physiological needs of the body. Materials and methods: A feasibility study about the effects of the most modern cryopreservation techniques on the structural and functional integrity of the follicular cells of the thyroid tissue has been carried out. Patients who could benefit from the treatment have been found for both autotransplant techniques. Additionally, a literature review has been conducted. Results: The histological analysis has shown that cryopreservation does not alter the original architecture, and the culture examination that cell viability is successfully preserved. Moreover, both thyroid autotransplantation studies on animals and those on humans that were found in the literature have shown good results regarding the viability and functionality of the transplant. Conclusions: The viability of cryopreserved thyroid tissue found in this study is encouraging. Further studies to evaluate the levels of FT3, FT4 and thyroglobulin in thyroid tissue after cryopreservation are needed to verify that the secretory properties of the thyrocytes have been maintained intact. Furthermore, autotransplanted cases found in the literature do not have a long-term follow-up.

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“…However, this is not critical if the implantation is heterotopic. It is well known that thyroid gland transplants can survive under the skin, in muscles or under the kidney capsule and still produce hormones [53,54]. In case of heterotopic implantation under highly vascularized kidney capsula there is no need for large-diameter blood vessels connected to the bioprinted thyroid gland construct.…”

Section: Discussionmentioning

confidence: 99%

Bioprinting of a functional vascularized mouse thyroid gland construct

et al. 2017

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Bioprinting can be defined as additive biofabrication of three-dimensional (3D) tissues and organ constructs using tissue spheroids, capable of self-assembly, as building blocks. The thyroid gland, a relatively simple endocrine organ, is suitable for testing the proposed bioprinting technology. Here we report the bioprinting of a functional vascularized mouse thyroid gland construct from embryonic tissue spheroids as a proof of concept. Based on the self-assembly principle, we generated thyroid tissue starting from thyroid spheroids (TS) and allantoic spheroids (AS) as a source of thyrocytes and endothelial cells (EC), respectively. Inspired by mathematical modeling of spheroid fusion, we used an original 3D bioprinter to print TS in close association with AS within a collagen hydrogel. During the culture, closely placed embryonic tissue spheroids fused into a single integral construct, EC from AS invaded and vascularized TS, and epithelial cells from the TS progressively formed follicles. In this experimental setting, we observed formation of a capillary network around follicular cells, as observed during in utero thyroid development when thyroid epithelium controls the recruitment, invasion and expansion of EC around follicles. To prove that EC from AS are responsible for vascularization of the thyroid gland construct, we depleted endogenous EC from TS before bioprinting. EC from AS completely revascularized depleted thyroid tissue. The cultured bioprinted construct was functional as it could normalize blood thyroxine levels and body temperature after grafting under the kidney capsule of hypothyroid mice. Bioprinting of functional vascularized mouse thyroid gland construct represents a further advance in bioprinting technology, exploring the self-assembling properties of tissue spheroids.

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Thyroid Follicle Transplantation by Percutaneous Injection

Cited by 6 publications

References 8 publications

Functional capacity of the thyroid autograft and heterograft: An experimental study

Functional capacity of the thyroid autograft and heterograft: An experimental study

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Bioprinting of a functional vascularized mouse thyroid gland construct

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