Thyroid Function and Obesity

Longhi, Silvia; Radetti, Giorgio

doi:10.4274/jcrpe.856

Cited by 49 publications

(24 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increase in leptin levels and cytokines secreted from adipose tissue causes increase in deiodinase activity and decrease in iodine uptake in thyroid tissue. Changes in thyroid function are reversible and thyroid function tests become normal after losing weight ( 42 ). Thyroid hormone is an important modulator in the lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents

Elmaoğulları¹,

Tepe²,

Uçaktürk³

et al. 2015

Jcrpe

View full text Add to dashboard Cite

Objective:Childhood-onset obesity is associated with increased mortality and morbidity related to cardiovascular diseases (CVD) during adulthood. Dyslipidemia has a fundamental role in the pathogenesis of CVD. This study aimed to evaluate the prevalence of dyslipidemia and related factors among obese children and adolescents.Methods:Obese patients aged between 2 and 18 years were included in the study. Serum concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), fasting glucose levels, insulin, thyroid-stimulating hormone (TSH), free thyroxine (fT4), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and liver ultrasound findings were evaluated retrospectively.Results:Among 823 obese patients, 353 (42.9%) met the dyslipidemia criteria: 21.7% had hypertriglyceridemia, 19.7% had low levels of HDL-C, 18.6% had hypercholesterolemia, and 13.7% had high levels of LDL-C. Older age and/or high body mass index (BMI) were related to increased prevalence of dyslipidemia. Hepatosteatosis was more common among dyslipidemic patients. The frequency of insulin resistance (IR) and of higher levels of ALT and TSH were also detected in dyslipidemic patients. Patients with both dyslipidemia and grade 2-3 hepatosteatosis had higher levels of ALT, AST and TSH and lower levels of fT4.Conclusion:Prevalence of dyslipidemia is high in obese children, and hypertriglyceridemia is in the foreground. Higher levels of IR and more apparent abnormal liver function test results are observed in the context of dyslipidemia and hepatosteatosis coexistence. Metabolic and hormonal alterations related with thyroid functions may also be associated with dyslipidemia and hepatosteatosis in obese patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents

Elmaoğulları¹,

Tepe²,

Uçaktürk³

et al. 2015

Jcrpe

View full text Add to dashboard Cite

show abstract

“…As a result, plasma exudation and imbibition of parenchyma occur. This situation differs from the autoimmune thyroiditis that was confirmed by a fine-needle biopsy, which did not show lymphocyte infiltrations, ruling out Hashimoto's disease as a cause of parenchyma derangement [21]. It is also suggested that the hypoechogenic image of the thyroid gland in obese subjects may result from the accumulation of adipose tissue [15].…”

Section: Does Obesity Influence Ultrasound Imaging Of the Thyroid Gland?mentioning

confidence: 78%

“…In summary, in adult obese individuals the prevalence of thyroid autoimmunity (assessed by the presence of antithyroid antibodies) does not differ from the normal-weight population even in those with elevated TSH levels. In contrast, in a study performed in paediatric obese patients, antithyroid autoantibodies were found significantly more often than in normal-weight peers [21]. The prevalence of elevated aTPO and aTG levels in obese subjects in different populations is summarised in Table II.…”

Section: Does Obesity Increase the Risk Of Aitd?mentioning

confidence: 86%

Diagnosis and treatment of thyroid disorders in obese patients — what do we know?

Gajda

Kuryłowicz

Żach

et al. 2019

Endokrynologia Polska

View full text Add to dashboard Cite

Obesity-related changes in the composition of the body interfere with the proper functioning of the thyrotropic axis, leading to its disturbances and changes in the structure of the thyroid gland. Distinguishing what is related to obesity and what constitutes pathological changes is crucial for the proper treatment of patients. In this paper authors present a case of a patient with a diet-induced obesity, whose only abnormalities in thyroid assessment included an elevated level of thyroid stimulating hormone (TSH) and hypoechoic thyroid gland on ultrasound. Based on this clinical situation, we reviewed literature in order to establish rules regarding management of thyroid disorders in obese individuals. The most common obesity-related thyroid abnormality is an isolated increase of TSH, without clinical symptoms of hypothyroidism, defined as hyperthyrotropinaemia. In obese adults, autoimmune thyroid disease is found equally often as in the normal-weight population. Thyroid enlargement, increased risk of nodules, and decreased echogenicity, not related to autoimmunity, is frequent among obese individuals. Weight loss leads to the normalisation of TSH levels and thyroid echogenicity. Excessive weight can influence both the TSH level and ultrasound image of the thyroid gland; however, these findings can be reversed by weight reduction. Therefore, in asymptomatic obese patients elevated TSH should not be treated with thyroid hormone replacement.

show abstract

“…As mentioned previously, high levels of leptin have been found in adults and children with obesity. Likewise, the development of secondary hypothyroidism has been reported in subjects with leptin deficiency or resistance [18,61]. Leptin also regulates central and peripheral Ds activity, affecting deiodination (and therefore the bioactivity) of T4 and T3 [62].…”

Section: Prace Poglądowementioning

confidence: 97%

“…It is generally accepted that a positive energy balance (obese subjects) presents increased TSH and free T3 concentrations [18]. On the other hand, a negative energy balance in obese and thin humans inhibits the activity of the HPT, and gonadal and hypothalamuspituitary-somatotrope axis, while stimulating the adrenal axis [19].…”

Section: Prace Poglądowementioning

confidence: 99%

Hormony tarczycy i otyłość: znana, lecz słabo rozpoznana relacja

García‐Solís

Garcı́a

Hernández-Puga

et al. 2018

Endokrynologia Polska

View full text Add to dashboard Cite

Hormony tarczycy (thyroid hormones, TH) są zaangażowane w wiele różnych procesów biologicznych, wliczając rozwój układu nerwowego, regulację metabolizmu pośredniego oraz zużycie energii. Aktywnie uczestniczą w podstawowym zużyciu energii i termogenezie adaptacyjnej i z tego względu mogą mieć wpływ na masę ciała w przebiegu chorób tarczycy. Otyłość to niezakaźna, przewlekła, zapalna choroba metaboliczna, która implikuje dodatni bilans energetyczny. Tkanka tłuszczowa produkuje szereg hormonów i adipocytokin, takich jak leptyna, które mogą wpływać na stan tarczycy na różnych poziomach. Istnieją dowody na to, że dysfunkcja tarczycy może predysponować do otyłości i odwrotnie, istnieją dowody sugerujące, że otyłość powoduje zmiany dotyczące tarczycy. Celem tej pracy było opisanie związku między układem tarczycy a otyłością. Ponadto w pracy zaprezentowano hipotetyczny model podkreślający znaczenie obwodowej dejodynacji hormonów tarczycy i jego rolę w ustanowieniu dodatniego bilansu energetycznego. Podsumowując, możemy stwierdzić, że relacja między układem tarczycy a otyłością i nadwagą jest złożona i obejmuje wiele poziomów interakcji. Ponadto, poddając ocenie otyłego pacjenta, powinno się rozważyć ocenę funkcji tarczycy, aby uzyskać lepsze i spersonalizowane efekty leczenia.

show abstract

Thyroid Function and Obesity

Cited by 49 publications

References 46 publications

Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents

Prevalence of Dyslipidemia and Associated Factors in Obese Children and Adolescents

Diagnosis and treatment of thyroid disorders in obese patients — what do we know?

Hormony tarczycy i otyłość: znana, lecz słabo rozpoznana relacja

Contact Info

Product

Resources

About