Thyroid function and thyroid autoantibodies in patients with chronic spontaneous urticaria

Czarnecka‐Operacz, Magdalena; Sadowska‐Przytocka, Anna; Jenerowicz, Dorota; Szeliga, Anna; Adamski, Zygmunt; Łącka, Katarzyna

doi:10.5114/ada.2017.72464

Cited by 13 publications

(8 citation statements)

References 24 publications

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“…Moreover, some studies reported Tg receptor expression in non-thyroid tissue such as skin and human brain thus suggesting a role of Tg in these tissues (Naicker and Naidoo, 2018) which then implies that TgAb antibodies may disrupt that role. There is known connection of thyroid autoimmunity with skin disorders like chronic urticaria (Czarnecka-Operacz and Sadowska-Przytocka et al, 2017), vitiligo (Baldini and Odorisio et al, 2017) and increased skin autoreactivity (Turkoglu and Zindanci et al, 2012). One case report already documented an association of TgAb with facial edema in euthyroid individual (Miralles and Soriano et al, 2002) thus providing more evidence for our finding.…”

Section: Discussionsupporting

confidence: 69%

Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto’s Thyroiditis: A Cross-Sectional Study

Barić

Brčić

Gračan

et al. 2018

Immunological Investigations

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Background: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characterization of patients with HT, with specific focus on thyroid autoimmunity, to get better understanding of disease manifestation. Methods: We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes. Results: Our key and novel finding is the existence of significant positive correlation between TgAb levels and the number of symptoms (r = 0.25, p = 0.0001) in HT patients without LT4 therapy that remained significant after adjustment for TPOAb, T3, TSH levels and thyroid volume (β = 0.66, SE = 0.3, p = 0.0299). Increased TgAb levels are significantly associated with fragile hair (p = 0.0043), face edema (p = 0.0061), edema of the eyes (p = 0.0293) and harsh voice (p = 0.0349). Conclusions: Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. Based on these results, we recommend screening for TgAb antibodies in HT patients with symptom burden. We also suggest that further work on understandings of symptoms appearance due to their autoimmune or hypothyroid causation is needed.

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Section: Discussionsupporting

confidence: 69%

Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto’s Thyroiditis: A Cross-Sectional Study

Barić

Brčić

Gračan

et al. 2018

Immunological Investigations

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“…34 Several studies suggest that adequate therapy with antithyroid drugs or levothyroxine in early stages may help to achieve remission of CSU. 44 Kim et al reported that 2 out of 10 patients with CSU and HT, showed improvement in urticaria symptoms when levothyroxine was administered. 35 Magen et reported that patients with CSU and hypothyroidism, showed a decrease of the urticaria activity score (UAS) when levothyroxine was added to the treatment; nevertheless, in euthyroid patients, there was no significant difference after 3-6 months of levothyroxine treatment.…”

Section: Treatment Of Urticaria and Autoimmune Thyroid Diseasementioning

confidence: 99%

Chronic urticaria and thyroid pathology

González‐Díaz

Sánchez‐Borges

Rangel-Gonzalez

et al. 2020

World Allergy Organization Journal

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Urticaria is defined as the sudden appearance of erythematous, itchy wheals of variable size, with or without angioedema (AE) (swelling of the deeper layers of the skin). Its classification depends on time course of symptoms and the presence of eliciting factors. When it lasts less than 6 weeks it is classified as acute urticaria (AU), and if the symptoms persist for more than 6 weeks, it is classified as chronic urticaria (CU). Current International Guidelines also classify CU as chronic spontaneous urticaria (CSU) and inducible urticarial, according to the absence or presence of environmental triggering factors. CSU is defined as urticaria and/or angioedema in which there is no evidence of a specific eliciting factor. CSU is associated with autoimmunity in 30-45% of the cases, sharing some immunological mechanisms with other autoimmune diseases, and is associated with autoimmune thyroid disease (ATD) in about 4.3%-57.4% patients. Several studies suggest that adequate therapy with anti-thyroid drugs or levothyroxine in early stages of ATD and CSU, may help to remit the latter; but there is still a lack of double-blind, placebo-controlled studies that support this hypothesis in patients without abnormal thyroid hormone levels. The objective of this review is to describe the pathophysiology of chronic spontaneous urticaria and its association with autoimmune thyroid disease.

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“…Increased levels of D-dimers are associated with increased platinum processing of fibrin. What is also significant is that D-dimers are also responsible for the release of histamine from mast cells [ 11 , 12 ]. It seems that markers of haemostasis can be useful in monitoring the activity of the disease process in the course of CSU and the effects of its treatment.…”

Section: Discussionmentioning

confidence: 99%

The relationship between the severity of clinical symptoms of chronic urticaria and serum D-dimer levels

Sadowska‐Przytocka

Czarnecka‐Operacz

Łącka

et al. 2021

pdia

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Introduction Urticaria and angioedema belong to a heterogeneous group of diseases and it is often very difficult to determine the specific cause of clinical symptoms. Coagulation factors play an important role, and patients with chronic urticaria have elevated plasma concentrations of coagulation factor VII, prothrombin fragment 1 + 2 and D-dimers. Aim To assess the relationship between the severity of clinical symptoms of chronic urticaria and serum D-dimer levels. Material and methods Sixty patients with a diagnosis of chronic spontaneous urticaria, diagnosed and treated in the Dermatology Department of the Poznan University of Medical Sciences were qualified for the tests. The control group consisted of 35 healthy volunteers. All patients with chronic spontaneous urticaria were previously subjected to individual stages of the diagnostic process, in accordance with the guidelines of EAACI and the Polish team of specialists in the field of dermatology and venereology, and allergology. The dermatological condition was assessed using the UAS scale. The serum D-dimer concentration was determined by immunoturbidimetry. Results In the basic group, statistically significant, positive and high correlations between the serum D-dimer concentration and the severity of urticaria symptoms were shown, as well as between the severity of pruritus and the value of the disease activity index were shown. Conclusions Elevated levels of D-imers are significantly correlated with the severity of urticaria.

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Thyroid function and thyroid autoantibodies in patients with chronic spontaneous urticaria

Cited by 13 publications

References 24 publications

Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto’s Thyroiditis: A Cross-Sectional Study

Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto’s Thyroiditis: A Cross-Sectional Study

Chronic urticaria and thyroid pathology

The relationship between the severity of clinical symptoms of chronic urticaria and serum D-dimer levels

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