Thyroid function in abnormal uterine bleeding

Abstract

Background: AUB is any abnormal uterine bleeding in the absence of any palpable pelvic pathology and demonstrable extra genital causes. AUB is responsible for 10% of gynaecological complaints. Thyroid hormone is very important to affect the menstrual pattern. The objective of this study was to evaluate thyroid function test in women with AUB and to assess the menstrual pattern in women with thyroid dysfunction. Methods: The present study was conducted in the Department of Obstetrics and Gynecology, Laxmi Narasimha Hospital, Hanamkonda, Hyderabad, Telangana, India 80 women of reproductive age group between 15-45 years women with menstrual disorders like menorrhagia, oligomenorrhea, hypomenorrhea, polymenorrhea, metrorrhagia, and amenorrhea. Quantitative determination of T3, T4, and TSH by CLIA estimated in autoanlyser. Results: About 80 women participated in the study in which Most of the subjects belong to 26-30 years of age group. Maximum patients i.e. 41 (51.2%) patients were para one to 2. Commonest cause bleeding pattern was menorrhagia 41.25%. 15 apparently normal patients with AUB belonged to the category of subclinical hypothyroidism (15%). Hormonal levels revealing profound hypothyroidism in patients without any symptoms was present in only 10% of cases. 2.5% of cases had hyperthyroidism though they were clinically normal. Patients who were sub-clinically hypothyroid were maximally presenting as polymenorrhoea (50%) and menorrhagia (12.1%) and only 6.27% of patients had oligomenorrhoea. Patients who were profound hypothyroid were predominantly having polymenorrhagia (83.3%) and (62.5%) of patients had oligomenorrhoea. Conclusions: So, biochemical evaluation of thyroid functioning should be made mandatory in all provisionally diagnosed cases of AUB to detect thyroid dysfunction.

Thyroid disorders in reproductive age presenting with abnormal uterine bleeding

“…Similarly in study by Kundoor R et al 10 majority of thyroid disorder was subclinical hypothyroid (15%), followed by hypothyroid 10% and hyperthyroid 2.5%. In study by Sudha HC et al 8 euthyroid constituted 62% patients, hypothyroid 12%, Subclinical hypothyroid in 16% and hyperthyroid in 2% patients.…”

Subclinical Hypothyroidism in Perimenopausal Abnormal Uterine Bleeding Patients

“…According to Kolli et al, in patients with subclinical and overt hypothyroidism, menorrhagia was found to be 55% prevalent, followed by polymenorrhagia, acyclical bleeding, polymenorrhea, oligomenorrhea, and metrorrhagia [ 18 ]. In another study conducted among women of reproductive age, subclinical hypothyroidism was found in about 15 seemingly normal individuals with AUB (15%) [ 19 ]. Pujari et al conducted a study in a tertiary hospital in India on patients with subclinical hypothyroidism.…”

Assessment of thyroid disorders prevalence in women during reproductive age

“…The cases of thyroid dys-function are on rise worldwide [4] . In India also the same is observed for which there may be multiple causes like family history or lifestyle modifications or excess of stress [7] . Earlier studies reported that there was more cases of hypothyroidism and sub clinical hypothyroidism in the women of reproductive age [8] .…”