Thyroid Function in Molar Pregnancy

Kock, H.; Kessel, H. Van; Stolte, L.A.M.; Leusden, H. van

doi:10.1210/jcem-26-10-1128

Cited by 31 publications

(12 citation statements)

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“…However, Burger's report that crude urinary preparations of human chorionic gonadotropin contain a thyrotropic factor suggests that placental thyrotropin circulates (7). Several reports on thyroid function in patients with choriocarcinoma or mole suggest that the abnormal trophoblast secretes a thyroid stimulator (5,(26)(27)(28). It is also possible that the placental material is secreted into the fetal circulation and stimulates the fetal thyroid.…”

Section: Resultsmentioning

confidence: 99%

Extraction and characterization of a thyrotropic material from the human placenta

Hershman¹,

Starnes²

1969

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

Extraction and characterization of a thyrotropic material from the human placenta

Hershman¹,

Starnes²

1969

J. Clin. Invest.

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“…It is also of clinical interest that hyperthyroidism is present in cases of trophoblastic neoplasia (Odell et al, 1963;Kock et al, 1966;Galton et al, 1971;Hershman et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

Human Chorionic TSH (hCTSH, hCT) during Normal or Molar Pregnancy

et al. 1973

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SynopsisUsing a purified human chorionic TSH (hCTSH), which was extracted from the term placenta, the authors developed a method of radioimmunoassay of hCTSH and estimated serum hCTSH in normal or molar pregnancy along with estimations of pituitary TSH (hPTSH), total thyroxine (T4) and effective thyroxine ratio (ETR). As a result, hPTSH level remained within the non-pregnant range throughout the whole course of pregnancy, but hCTSH tended to increase gradually toward the terminal stage of pregnancy. T4 and ETR remained within the non-pregnant range but the former showed gradual increase toward the term. In molar pregnancy, the hPTSH level was normal but the level of hCTSH was markedly high. The same applied to T4 and ETR.After molar delivery hCTSH disappeared rapidly accompanied with gradual decrease in T4 and ETR.

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“…More recently, Kock, Kessel, Stolte, and Leusden confirmed the elevation of PBI in six patients, and found that the resin uptake of '31I-labeled triiodothyronine (T3), assessed in two patients, was in the same range as in normal pregnancy. An 31J-tracer test performed in one patient indicated a very high thyroidal 131I uptake, conversion ratio, and thyroidal "1I-secretion rate (3).…”

Section: Introductionmentioning

confidence: 91%

Alterations in thyroid hormone economy in patients with hydatidiform mole

Galton¹,

Ingbar²,

Jimenez-Fonseca³

et al. 1971

J. Clin. Invest.

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A B S T R A C T Studies of several aspects of thyroid hormone economy have been conducted in 11 patients before and after removal of a molar pregnancy. Before evacuation of the mole, all patients demonstrated moderately to greatly elevated values for thyroidal 'I uptake, absolute iodine uptake, and serum protein-bound-I. Values for serum PBI and serum thyroxine (T4) concentration were consistently and often greatly increased, averaging more than twice those found in normal pregnancy and three times those in normal controls. On the other hand, the maximum binding capacity of the T4-binding globulin (TBG) was variably affected, and ranged between the values found in normal controls and those found in normal pregnancy. Values for the absolute concentration of free T4 in serum were, on the average, only moderately elevated, since the proportion of free To was moderately low, although not as low as in normal pregnancy. Sera of patients with molar pregnancy contained high levels of thyroid stimulating activity, as assessed in the McKenzie mouse bioassay system. The stimulator displayed a more prolonged duration of action than that of TSH and did not reveal a major immunological cross-reactivity with either human or bovine TSH, differing in the latter respect from the chorionic thyrotropin of normal human placenta. Abnormalities in iodine metabolism were rapidly ameliorated after removal of the molar pregnancy, and this was Despite the foregoing evidence of thyroid hyperfunction and hypersecretion of T4, patients with molar pregnancy were neither goitrous nor overtly thyrotoxic. They did display, however, high values of the urinary pigment/creatinine ratio, a possible indication of the presence of a hypermetabolic state.It is concluded that in patients with molar pregnancy, thyroid function and T4 secretion are stimulated, often greatly so, by an unusual thyroid stimulator which is demonstrable in the blood and which is probably of molar origin. The nature of the stimulator, as well as the reasons for both the variability of the increase in TBG which occurs in molar pregnancy and the lack of frank thyrotoxicosis, remain to be clarified.

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Thyroid Function in Molar Pregnancy

Cited by 31 publications

References 1 publication

Extraction and characterization of a thyrotropic material from the human placenta

Extraction and characterization of a thyrotropic material from the human placenta

Human Chorionic TSH (hCTSH, hCT) during Normal or Molar Pregnancy

Alterations in thyroid hormone economy in patients with hydatidiform mole

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