Thyroid function in patients with pustulosis palmoplantaris

Rosén, K; Lindstedt, Göran; Mobacken, H; Nyström, Ernst

doi:10.1016/s0190-9622(88)70265-0

Cited by 43 publications

(30 citation statements)

References 18 publications

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“…The prevalence of thyroid pathologies in PPP ranged from 16% to 25% in some studies, and these rates are significantly higher than these found in the general population [3, 13–15]. Our rate was 21% according to the history of thyroid disease in the PPP group, which was three-times higher than in the control group (21% vs. 7%).…”

Section: Discussioncontrasting

confidence: 51%

“…The rate in the control group was 7% according to the history of thyroid disease in our study. In addition, high frequencies of thyroid disease and thyroid autoantibodies were found in the patients with PPP in one previous study [13]. In another study of PPP, 3 (25%) and 2 (16%) of 12 patients were diagnosed with thyroid diseases and antimicrosomal antibodies, respectively [3].…”

Section: Discussionmentioning

confidence: 94%

“…The relationships between PPP and certain clinical features, such as gluten sensitivity, thyroid disease, diabetes mellitus and focal infections (like tonsillitis) have been demonstrated in recent studies [5, 6, 12, 13]. The increased frequency of thyroid disorders varies based on different studies, while the prevalence of thyroid pathologies is about 5% in the general population [3].…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid antigen antibodies are more common in women, with a rate of 8.4% in the general population [16]. Gul et al reported the frequency of thyroid autoantibodies in healthy Turkish individuals as 9.9% [17]; however, this rate has been reported as 22.5% in women with PPP [13]. In this study, a moderate correlation between the gender and anti-TPO levels was found ( r = 0.361, p = 0.039), while the anti-TPO rate was three-times higher in women than in men in the PPP group.…”

Section: Discussionmentioning

confidence: 99%

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Insulin resistance, diabetes mellitus and thyroid dysfunction in patients with palmoplantar pustulosis: a case-controlled study

Ataş

Gönül

2017

pdia

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IntroductionPalmoplantar pustulosis (PPP) is a chronic pustular inflammatory skin disease; however, its pathogenesis is not well understood. Several factors, such as genetics, tobacco use and autoimmune issues, may contribute to this disease.AimThis research was conducted to investigate the relationships between insulin resistance, thyroid disease and PPP.Material and methodsThirty-three patients with PPP and 27 age- and gender-matched controls were analysed for their smoking histories, thyroid function tests, anti-thyroid peroxidase antibody (anti-TPO) levels, fasting glucose, fasting insulin levels and the homeostatic model assessment (HOMA) index for insulin resistance.ResultsWe found significant differences between the PPP and control groups according to their tobacco use and anti-TPO levels (p = 0.009 and p = 0.009, respectively). The proportion of tobacco use was 90% in the PPP patients and 63% in the controls. Gender and tobacco use were predictive risk factors for PPP in the multivariate analysis (OR = 141.7, p < 0.0001 and OR = 147.6, p = 0.006, respectively). An anti-TPO level > 35 U/ml and the presence of a thyroid abnormality were independent risk factors in the univariate, but not the multivariate analysis (OR = 4.2, p = 0.025 and OR = 5.4, p = 0.004, respectively). A moderate correlation between the gender and anti-TPO level was found (r = 0.361, p = 0.039); however, the fasting glucose, insulin and HOMA index were not significant between the PPP and control groups.ConclusionsFemale gender and smoking were the most important risk factors for PPP; however, the increase in the anti-TPO level may be related to the predominance of females afflicted with this disease. Additional studies are necessary to clarify the relationships between PPP, thyroid disease and diabetes mellitus.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Insulin resistance, diabetes mellitus and thyroid dysfunction in patients with palmoplantar pustulosis: a case-controlled study

Ataş

Gönül

2017

pdia

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“…65 Several observational and case-control studies have demonstrated up to 94% prevalence of tobacco use in patients with PPP. [66][67][68] Eczema The association between eczema and smoking has been a subject of controversy. 69 One study of 678 preschool children correlated a positive history of maternal smoking with atopic dermatitis.…”

Section: Psoriasismentioning

confidence: 99%