Thyroid Function in Patients with Mongolism

Pearse, J; Reiß, M.; Suwalski, R.

doi:10.1210/jcem-23-3-311

Cited by 31 publications

(5 citation statements)

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“…All but one of the patients with elevated titers of TAB also had detectable AMA, although the prevalence of AMA was higher (32 % versus 17 %). Inappropriately high T3U has also been documented by others (Pearse et al 1963, Saxena & Pryles 1965. The test appears to be unreliable in Down syndrome (Saxena & Pryles 1965).…”

Section: Discussionmentioning

confidence: 77%

Prevalence of thyroid disorder in Down syndrome

1978

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Thyroid function has been studied in 121 patients between 13 and 48 years old with proven Down syndrome. Chemically, hypothyroidism was found in 17 % and hyperthyroidism in 2.5 % of the patients; 18 % of patients had goiter. Thyroid antibodies were detected in 33 % of subjects studied. The abnormal findings were almost equally distributed between the sexes above 20 years of age; however, females had significantly more thyroid disease than males in the younger age group.

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Section: Discussionmentioning

confidence: 77%

Prevalence of thyroid disorder in Down syndrome

1978

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“…These last results might suggest that abnormal TBG or iodoprotein was present in the serum of some mongols, but methodological explanations for the abnormal findings cannot be excluded. Pearse, Reiss, and Suwalski (1963) reported low thyroid 131I uptakes in 17 out of 125 male and seven out of 26 female mongols, and a high uptake in one patient. They also stated that diffuse or nodular thyroid enlargements were noted in many of their patients.…”

Section: Genetic and Developmental Disordersmentioning

confidence: 81%

The interpretation of the serum protein-bound iodine: A review

Acland

1971

J Clin Pathol

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“…Congenital hypothyroidism is commoner in DS (Fort et al, 1984), although its aetiology is unclear. Early studies with proteinbound iodine (Simon et al, 1954), radioactive iodine uptake (Friedman, 1955) and T3 resin uptake (Pearse et at., 1963;Saxena & Pryles, 1965) showed that there was no consistent change in thyroid function associated with DS. However, acquired autoimmune thyroid disease is common and often occurs prematurely; thus, hyperthyroidism, and more particularly hypothyroidism, are well recognized to occur with increased frequency in DS (for review of early case reports see Aarskog, 1969).…”

mentioning

confidence: 99%