Thyroid Function Tests in Preeclampsia

Chowdhary, Sumaira; Aara, Shaugfta; Nazeer, Masarat; Allaqband, Musadiq

doi:10.18535/ijmsci/v5i3.09

Cited by 2 publications

(5 citation statements)

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“…Consistent with our findings, several studies have observed lower TT4 and TT3 levels in preeclampsia [ 7 , 16 , 35 ]. According to other studies, women with preeclampsia have increased antiangiogenic factors, which in turn reduce nitric oxide production.…”

Section: Discussionsupporting

confidence: 93%

“…Naturally, thyroid hormones increase by 40–100% to meet the needs of both mother and fetus [ 6 ]. In a normal pregnancy, Thyroid Stimulating Hormone (TSH) increases due to an increase in concentration of Human Chorionic Gonadotropin (HCG) [ 7 ]. Total Thyroxine(TT4) and Total Triiodothyronine(TT3) concentrations increase rapidly, while Free Triiodothyronine and Free Thyroxine (FT3 and FT4) increase at a slower rate [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…About 45- 70% of thyroid hormones bind to thyroxine-binding globulin (TBG) and the rest to trans-thyrotin and albumin. [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis

et al. 2022

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Background Preeclampsia is a life-threatening disorder during pregnancy and postpartum periods. Preeclampsia can affect the activity of many organs. It is very important because if this disorder is associated with changes in thyroid function, it can affect the results of maternal and fetal tests. Accordingly, the aim of this meta-analysis study was to assess the abnormalities in thyroid function tests in preeclampsia. Methods Studies were selected through a systematic search of the MEDLINE/PubMed, Scopus, Web of Science Core Collection, and Google Scholar databases in 31st August 2021. Also, reference lists of review articles and relevant studies were manual-searched to identify other potentially eligible studies. English studies that compared TSH, T4 and T3 of normal pregnant with preeclamptic women (Known to be normotensive before pregnancy; gestational age 20 week or more; singleton pregnancy; no previous history of thyroid dysfunction) were screened. Data sets were screened for eligibility by two independent reviewers. Articles were assessed by the Newcastle–Ottawa Scale. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used for quality assessment of evidence on outcome levels. Results After reviewing 886 published studies, 63 observational studies were selected and used for this meta-analysis. The study population included 21,528 pregnant women. The findings revealed that TSH (SMD = 1.70, 95%CI: 1.39 to 2.02; p < 0.001) was significantly higher in preeclamptic women. TT4 (SMD = -0.82, 95%CI: -1.16, -0.49; p < 0.001), TT3 (SMD = -0.88, 95%CI: -1.36 to -0.41; p < 0.001) and FT3 (SMD = -0.59, 95%CI: -0.91 to -0.27; p < 0.001) were less in preeclamptic women. There was no statistically significant difference in FT4 between two groups (SMD = 0.002, 95%CI: -0.27 to 0.27; p = .990). The results of publication bias and sensitivity analysis confirmed the reliability and stability of this meta-analysis. The quality of evidence was regarded as moderate, low, and very low for these risk factors according to the GRADE approach. Conclusions Findings of this meta-analysis indicated preeclamptic women were more at risk of changes in thyroid function tests. In order to prevent thyroid disorders, it is recommended that thyroid function tests be performed in women with pre-eclampsia.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis

et al. 2022

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“…Thyroid hormone levels naturally rise by 40-100% based on the nutritional requirements of both the mother and the fetus [5]. Thyroid Stimulating Hormone (TSH) rises in a healthy pregnancy as a result of an increase in Human Chorionic Gonadotropin (HCG) concentration [6]. While free triiodothyronine and free thyroxine (FT3 and FT4) increase more slowly, total thyroxine (TT4) and total triiodothyronine (TT3) concentrations rise quickly [5].…”

Section: Introductionmentioning

confidence: 99%

“…Only 0.2% of T3 and 0.02% of T4 are free in the serum, whereas the majority of thyroid hormones are protein bound. The majority of thyroid hormones-between 45 and 70 percent bind to thyroxine-binding globulin (TBG), with the remainder bound to albumin and transthyrotin [6].…”

Section: Introductionmentioning

confidence: 99%

Frequency of Pregnancy Induced Hypertension (PIH) in Patients Presenting with Hypothyroidism

Atif,

Imran,

Ilyas

et al. 2023

PJMHS

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Objective: Preeclampsia is a potentially fatal condition during pregnancy and following delivery. Numerous organs' functions can be influenced by preeclampsia. It is crucial, as this illness may be linked to abnormalities in thyroid function. Therefore, the aim of this study was to assess the frequency of thyroid dysfunction and its association with hypertension in pregnant women. Methodology: This descriptive cross sectional study was conducted at Obstetrics and Gynecology Unit-I, Civil Hospital, Karachi, using a non-probability consecutive sampling technique. The duration of the study was about six months from October 2022 till March 2023. A total of 80 pregnant women who were between the ages of 18 and 40, had gestational ages between 20 and 40 weeks, and had laboratory results that suggested hypothyroidism were included in this study. A chi-square test was applied to evaluate the association between maternal age, parity, gestational age, serum levels of TSH and T4 and pregnancy induced hypertension. Results: The study findings showed that most of the women 33(41.25%) were between 26 to 35 years of age. The mean age of the pregnant women was 29.43±4.64 years. The mean parity was 1.74±0.83 and the mean gestational age was 30.33±5.22 weeks, and the mean duration of hypothyroidism was 4.27±2.06 years. Concerning thyroid parameters, the mean T4 was 5.79±1.21 pmol/L, and the mean TSH was 6.28±2.03 mIU/L. Additionally, there was an insignificant association observed between pregnancy induced hypertension and maternal age, gestational age, parity, and thyroid hormone parameters. Conclusion: This study concluded that alterations in the thyroid function of pregnant women led to pregnancy induced hypertension. Only 25% of hypothyroid pregnant women had gestational hypertension. Furthermore, age, parity, gestational age, and thyroid parameters of pregnant women were insignificantly associated with pregnancy induced hypertension. Keywords: Pregnancy induced hypertension, hypothyroidism, gestational age.

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Thyroid Function Tests in Preeclampsia

Cited by 2 publications

References 1 publication

Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis

Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis

Frequency of Pregnancy Induced Hypertension (PIH) in Patients Presenting with Hypothyroidism

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