Thyroid hormones and thyroid antibodies in infertile males

Trummer, Harald; Ramschak-Schwarzer, Sigrid; Haas, Josef; Habermann, Helga; Pummer, Karl; Leb, G.

doi:10.1016/s0015-0282(01)01875-1

Cited by 37 publications

(24 citation statements)

References 13 publications

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“…In the latter group, TAI was found in 7.5% of the men and elevated thyroid antibody titers were significantly correlated with asthenozoospermia. Subclinical hypothyroidism was present in 3% of the cases, but was not correlated with altered semen density, sperm motility or morphology (21).…”

Section: Discussionmentioning

confidence: 84%

“…These studies postulated that TAI and other organspecific antibodies were probably related to a common immune dysregulation (19,20). More recently, Trummer et al (21) investigated prospectively the impact of thyroid dysfunction and autoimmunity on semen in a large cohort of subfertile men. In the latter group, TAI was found in 7.5% of the men and elevated thyroid antibody titers were significantly correlated with asthenozoospermia.…”

Section: Discussionmentioning

confidence: 99%

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Is systematic screening for thyroid disorders indicated in subfertile men?

Poppe

Glinoer²,

Tournaye³

et al. 2006

eur j endocrinol

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Context: Data on the prevalence of thyroid disorders in male subfertility remain scarce. Objective: To investigate the prevalence of thyroid dysfunction and thyroid autoimmunity in men with normal and abnormal semen characteristics. Setting: Tertiary referral center for reproductive medicine of the University Hospital AZ-VUB, Brussels, Belgium. Patients and design: Two hundred and ninety-two men were stratified according to the presence of normal (group 1; n ¼ 39) or abnormal (group 2; n ¼ 253) semen characteristics. Thyroid function was assessed by serum thyrotropin (TSH) and free thyroxine (FT4), and thyroid peroxidase antibodies (TPO-Ab) for thyroid autoimmunity (TAI or TPO-Ab . 34 kU/l); both were correlated with semen characteristics. Main outcome measures: Semen characteristics were determined by World Health Organisation criteria (rapid þ slow motility $ 50% and concentration $20 £ 10 6 ) and Kruger criteria (morphology $ 14% normal cells). Results: In group 1, the mean (^S.D.) age was 33^4 years; serum TSH was 1.6 (0.3 -29.6) mU/l (median (range)) and FT4 was 12.2 (8.8 -15.6) ng/l. In group 2, the mean age was 33^5 years, serum TSH was 1.3 (0.3-5.2) mU/l and FT4 was 12.5 (8.4-17.5) ng/l; (compared with group 1 P ¼ 0:008 for TSH and P ¼ 0:037 for FT4). In both groups, one patient had increased TSH (2.6% and 0.4%; P ¼ not significant (ns)). In group 1, one patient had TAI and in group 2 twelve patients had TAI (2.6% compared with 4.7%; P ¼ ns). FT4 was an independent determinant for semen characteristics. Conclusions: The prevalence of thyroid dysfunction and autoimmunity is comparable between men with normal and abnormal semen characteristics. On the basis of these data, we do not advise systematic screening for thyroid disorders in subfertile men consulting a tertiary referral center for reproductive medicine.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Is systematic screening for thyroid disorders indicated in subfertile men?

Poppe

Glinoer²,

Tournaye³

et al. 2006

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…Apparently, post-pubertal hypothyroidism does not cause severe seminal alterations. Another study designed to investigate the correlation of thyroid dysfunction and semen parameters in infertile men, however, analyzed 305 patients and did not find any correlation between thyroid dysfunction and semen parameters, but between elevated thyroid peroxidase antibody (TPO-Ab) and panthozoospermia and asthenozoospermia (60). These results, conversely, were not confirmed in a recent cohort of subfertile men (61).…”

Section: Thyroid Hormone Disorders and Male Reproductionmentioning

confidence: 93%

Clinical implications of altered thyroid status in male testicular function

Wajner

Wagner

Maia

2009

Arq Bras Endocrinol Metab

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Thyroid hormones are involved in the development and maintenance of virtually all tissues. Although for many years the testis was thought to be a thyroid-hormone unresponsive organ, studies of the last decades have demonstrated that thyroid dysfunction is associated not only with abnormalities in morphology and function of testes, but also with decreased fertility and alterations of sexual activity in men. Nowadays, the participation of triiodothyronine (T3) in the control of Sertoli and Leydig cell proliferation, testicular maturation, and steroidogenesis is widely accepted, as well as the presence of thyroid hormone transporters and receptors in testicular cells throughout the development process and in adulthood. But even with data suggesting that T3 may act directly on these cells to bring about its effects, there is still controversy regarding the impact of thyroid diseases on human spermatogenesis and fertility, which can be in part due to the lack of well-controlled clinical studies. The current review aims at presenting an updated picture of recent clinical data about the role of thyroid hormones in male gonadal function. RESUMOOs hormônios da tireoide estão envolvidos virtualmente no desenvolvimento e na manutenção de todos os tecidos. As gônadas masculinas foram, por décadas, consideradas insensíveis aos hormônios tireoidianos. No entanto, estudos mais recentes têm demonstrado que disfunções tireoidianas estão associadas não somente a anormalidades na morfologia e na função dos testículos, mas também à diminuição da fertilidade e alterações na atividade sexual masculina. Atualmente, o papel da triiodotironina (T3) no controle da proliferação das células de Sertoli e Leydig, maturação testicular e esteroidogênese é amplamente aceito, bem como a presença de transportadores e receptores para o hormônio tireoidiano nos testículos durante o período de desenvolvimento e a idade adulta. No entanto, apesar dos dados que indicam que o T3 atua diretamente nos testículos humanos, persistem controvérsias em relação ao impacto das doenças tireoidianas sobre a espermatogênese e a fertilidade, o que pode ser em parte devido à escassez de estudos clínicos nessa área. Essa revisão tem por objetivo apresentar um panorama de dados clínicos atualizados sobre o papel dos hormônios tireoidianos na função gonadal masculina. Arq Bras Endocrinol Metab. 2009;53(8):976-82 Descritores

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“…The prevalence of thyroid antibody positivity in a population of infertile men was found to be 7.5%; there was no difference in prevalence of abnormal thyroid function tests in normozoospermic vs pathozoospermic patients (11.1 vs 11.8%), but when correlating thyroid autoimmunity with semen parameters, the authors found a significantly higher presence of TPO-Abs in pathozoospermic and asthenozoospermic vs normozoospermic infertile men (6.7% and 7.2% respectively vs 1.6%) (Trummer et al, 2001). This datum was not confirmed in other studies (Krassas et al, 2010).…”

Section: Hypothyroidism and Male Infertilitymentioning

confidence: 87%