THYROID I<sup>131</sup>METABOLISM IN THE ABSENCE OF THE PITUITARY: THE UNTREATED, HYPOPHYSECTOMIZED RAT1<sup>1</sup>

Taurog, Alvin; Tong, Winton; Chaikoff, I.L.

doi:10.1210/endo-62-5-646

Cited by 51 publications

(14 citation statements)

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“…Chromatograms were developed in a solvent system consisting of collidine: water: NH40H ( 2 ) and applied to Kodak Blue-Brand Xray film for radioautography.…”

mentioning

confidence: 99%

Accelerated Biliary Thyroxine Secretion in Rats Treated with 3-Methylcholanthrene

Newman

Fernández

Slayden

et al. 1971

Experimental Biology and Medicine

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“…Chromatograms were developed in a solvent system consisting of collidine: water: NH40H ( 2 ) and applied to Kodak Blue-Brand Xray film for radioautography.…”

mentioning

confidence: 99%

Accelerated Biliary Thyroxine Secretion in Rats Treated with 3-Methylcholanthrene

Newman

Fernández

Slayden

et al. 1971

Experimental Biology and Medicine

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“…In the experiments that involved measurements of specific activities of iodoamino acids, I 127 analyses were carried out by the Chaney method with the modifications described previously (3,5). In order that sufficient iodine for reliable analyses would be present on the chromatograms, 200-/xl portions of thyroid hydrolysates were chromatographed on Whatman No.…”

mentioning

confidence: 99%

Recovery of Thyroxine from Thyroid Protein Hydrolyzed with Pancreatic and Bacterial Proteases

1963

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“…In other words, amounts of growth hormone and of thyroxine that were effective in the hypophysectomized and the thyroidectomized rats, respectively, were without any effect on the It has been well established by others that thyroxine is necessary for the production of growth hormone by the pituitary (8)(9)(10)(11)(12)(13)(14)(15). It is also well established that a small amount of thyroxine is secreted from the thyroid gland in the absence of the pituitary (16)(17)(18). In our experiments, thyroxine was without any effect on transamidinase activity when administered to animals without a pituitary gland.…”

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confidence: 99%

A Bioassay for Thyroxine Based on Rat Kidney Transamidinase Activities

et al. 1970

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Kidneys removed from rats 6 weeks after thyroidectomy have been found to have low transamidinase activities which were similar to those found in kidneys from hypophysectomized rats. Injections of growth hormone into thyroidectomized rats or of thyroxine into hypophysectomized rats were without any effect on the low enzyme activities, whereas the injections of growth hormone into hypophysectomized rats or of thyroxine into thyroidectomized rats did have an effect on the low transamidinase activities. Thyroxine is concluded to have a concomitant or prerequisite role in the direct regulation of transamidinase activities by growth hormone. A bioassay for thyroxine based on the transamidinase activities of kidneys from thyroidectomized rats has been developed. (Endocrinology 87: 1237(Endocrinology 87: , 1970 K IDNEYS removed from rats one week after hypophysectomy have only a fraction of the transamidinase activities found in kidneys from sham-hypophysectomized rats (1). Hypophysectomized rats that had received injections of bovine growth hormone had greater kidney transamidinase activities than hypophysectomized rats, and the activities were an increasing linear function of the log of the dose of the growth hormone injected (1). This is to report that kidneys removed from rats six weeks after thyroidectomy have only a fraction of the transamidinase activities found in kidneys from shamthyroidectomized rats. Thyroidectomized rats that had received injections of thyroxine had greater transamidinase activities than thyroidectomized rats and the activities were an increasing linear function of the log of the dose of the thyroxine injected. Details of a bioassay for thyroxine and studies on the nature of the apparent reg-

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THYROID I¹³¹METABOLISM IN THE ABSENCE OF THE PITUITARY: THE UNTREATED, HYPOPHYSECTOMIZED RAT1¹

Cited by 51 publications

References 0 publications

Accelerated Biliary Thyroxine Secretion in Rats Treated with 3-Methylcholanthrene

Accelerated Biliary Thyroxine Secretion in Rats Treated with 3-Methylcholanthrene

Recovery of Thyroxine from Thyroid Protein Hydrolyzed with Pancreatic and Bacterial Proteases

A Bioassay for Thyroxine Based on Rat Kidney Transamidinase Activities

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THYROID I131METABOLISM IN THE ABSENCE OF THE PITUITARY: THE UNTREATED, HYPOPHYSECTOMIZED RAT11

Cited by 51 publications

References 0 publications

Accelerated Biliary Thyroxine Secretion in Rats Treated with 3-Methylcholanthrene

Accelerated Biliary Thyroxine Secretion in Rats Treated with 3-Methylcholanthrene

Recovery of Thyroxine from Thyroid Protein Hydrolyzed with Pancreatic and Bacterial Proteases

A Bioassay for Thyroxine Based on Rat Kidney Transamidinase Activities

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THYROID I¹³¹METABOLISM IN THE ABSENCE OF THE PITUITARY: THE UNTREATED, HYPOPHYSECTOMIZED RAT1¹