Thyroid-like follicular carcinoma of the kidney with metastases to the lungs and retroperitoneal lymph nodes

Dhillon, Jasreman; Tannir, Nizar M.; Matin, Surena F.; Tamboli, Pheroze; Czerniak, Bogdan; Guo, Charles C.

doi:10.1016/j.humpath.2010.01.026

Cited by 67 publications

(56 citation statements)

References 11 publications

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“…Eleven cases have been found in an unrestricted PubMed search. 52–56 Two of these had metastasis—1 to hilar lymph node 53 and 1 to lung 54 —proving their designation as a carcinoma. The nature of the tumor has no relationship to thyroid carcinoma, and the nomenclature stems purely from their light microscopic appearance.…”

Section: Nonpapillary Neoplasmsmentioning

confidence: 98%

Diagnostic Approach to Eosinophilic Renal Neoplasms

Kryvenko

Jordà

Argani

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

108

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Context Eosinophilic renal neoplasms include a spectrum of solid and papillary tumors ranging from indolent benign oncocytoma to highly aggressive malignancies. Recognition of the correct nature of the tumor, especially in biopsy specimens, is paramount for patient management. Objective To review the diagnostic approach to eosinophilic renal neoplasms with light microscopy and ancillary techniques. Data Sources Review of the published literature and personal experience. Conclusions The following tumors are in the differential diagnosis of oncocytic renal cell neoplasm: oncocytoma, chromophobe renal cell carcinoma (RCC), hybrid tumor, tubulocystic carcinoma, papillary RCC, clear cell RCC with predominant eosinophilic cell morphology, follicular thyroid-like RCC, hereditary leiomyomatosis–associated RCC, acquired cystic disease–associated RCC, rhabdoid RCC, microphthalmia transcription factor translocation RCC, epithelioid angiomyolipoma, and unclassified RCC. In low-grade nonpapillary eosinophilic neoplasms, distinction between oncocytoma and low-grade RCC mostly rests on histomorphology; however, cytokeratin 7 immunostain may be helpful. In high-grade nonpapillary lesions, there is more of a role for ancillary techniques, including immunohistochemistry for cytokeratin 7, CA9, CD10, racemase, HMB45, and Melan-A. In papillary eosinophilic neoplasms, it is important to distinguish sporadic type 2 papillary RCC from microphthalmia transcription factor translocation and hereditary leiomyomatosis–associated RCC. Histologic and cytologic features along with immunohistochemistry and fluorescence in situ hybridization tests for TFE3 (Xp11.2) and TFEB [t(6;11)] are reliable confirmatory tests. Eosinophilic epithelial neoplasms with architecture, cytology, and/or immunoprofile not qualifying for either of the established types of RCC should be classified as unclassified eosinophilic RCC and arbitrarily assigned a grade (low or high).

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Section: Nonpapillary Neoplasmsmentioning

confidence: 98%

Diagnostic Approach to Eosinophilic Renal Neoplasms

Kryvenko

Jordà

Argani

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

108

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“…1(pp9-88) , This extremely rare entity of renal cell carcinoma (RCC) has a great resemblance to thyroid follicular carcinoma, with only 8 cases reported in the literature. [2][3][4] None of these cases showed papillary thyroid carcinoma (PTC) nuclear features. We report the first case of carcinoma of the kidney with PTC nuclear features with no clinical or radiological evidence of a primary tumor in the thyroid gland or other sites.…”

Section: Introductionmentioning

confidence: 99%

Papillary Thyroid Carcinoma– Like Tumor of the Kidney

et al. 2011

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Thyroid carcinoma-like tumor of the kidney is an extremely rare variant of renal cell carcinoma. Most previously reported cases were incidental finding; and none of them showed papillary thyroid carcinoma (PTC) nuclear features. This study reports the first case of PTC (follicular variant)-like tumor of the kidney in which a female patient presented with hematuria, weight loss, and flank pain. Imaging studies revealed a left renal mass with enlarged hilar lymph nodes. Histologically, the renal tumor had a striking resemblance to follicular variant of PTC. However, no radiological abnormalities were found in the thyroid, mediastinum, or pelvis. Tumor cells were negative for thyroid markers (thyroglobulin and TTF1). According to the authors, this is the first case of PTC (follicular variant)-like tumor of the kidney.

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“…EMA, CK7 and vimentin showed frequent positivity. PAX8 has been reported positive in tumor cells [5]. Immunostaining for CK19, CK20, and 504 s protein shows variable results.…”

Section: Discussionmentioning

confidence: 99%

Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature

et al. 2014

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Thyroid-like follicular carcinoma of the kidney is an extremely rare histological variant of renal cell carcinoma. It was described only recently and is not included in the World Health Organization classification of renal tumors. This tumor characteristically shows similar histology to thyroid follicular carcinoma but lacks typical thyroid markers. Herein, we report a new case of thyroid-like follicular carcinoma of the kidney diagnosed in a partial nephrectomy specimen in a 68-year-old-woman. We present typical histological and immunohistochemical findings, discuss differential diagnosis and provide a review of the literature.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_186

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Thyroid-like follicular carcinoma of the kidney with metastases to the lungs and retroperitoneal lymph nodes

Cited by 67 publications

References 11 publications

Diagnostic Approach to Eosinophilic Renal Neoplasms

Diagnostic Approach to Eosinophilic Renal Neoplasms

Papillary Thyroid Carcinoma– Like Tumor of the Kidney

Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature

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