Thyroid screening in HIV-infected patients with antiretroviral therapy

Hatzl, Margit; Öllinger, Angela; Geit, Maria; Wiesinger, Klaus; Angerbauer, Kristina; Auböck, Josef; Gabriel, Michael

doi:10.1007/s00508-015-0733-7

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…Hypothyroidism and subclinical hypothyroidism have been reported by various studies. 15,21,22 The prevalence of subclinical hypothyroidism in this study was 7.8% which is similar to a study conducted before the advent of ART, 23 slightly higher than the studies conducted by Beltran et al 2003 and lower than Joshi et al 2016. In this study, we did not find any differences in the prevalence of thyroid dysfunction among the sexes.…”

Section: Discussionsupporting

confidence: 82%

Study of thyroid dysfunction in people living with HIV in Nepalese population undergoing antiretroviral therapy: a cross-sectional study

Sah

Ansari²,

Sah³

et al. 2023

Int J STD AIDS

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Introduction Thyroid dysfunction is one of the most common endocrine disorders in people living with HIV (PLHIV). The abnormality in thyroid function has been linked with the adverse effects of prolonged antiretroviral therapy (ART) in PLHIV, but its prevalence remains obscure. The present study aimed to determine the prevalence of impaired thyroid function and its relationship to ART duration in Nepalese people living with HIV. Methods This cross-sectional clinical laboratory based study was conducted at SRL Diagnostics Nepal, Pvt. Ltd. from October 2021 to May 2022. Two hundred and three HIV-seropositive patients enrolled at Tribhuvan University Teaching Hospital (TUTH) in Kathmandu, Nepal were examined for their thyroid function test (TFT) by analyzing the serum T3, T4, and TSH concentrations using a fully automated COBAS e411 analyzer (Roche Diagnostics, USA) based on the electrochemiluminescence assay (ECLIA). Results Out of 203 PLHIV, 22 (10.83%) had a thyroid disorder, with subclinical hypothyroidism ( n = 16, 72.73%) being the most common, followed by subclinical hyperthyroidism ( n = 3, 13.63%). Thyroid dysfunction had no significant correlation with HIV/ART duration ( p = 0.304) and sex ( p = 0.419), whereas, the risk of thyroid dysfunction was induced with the rise in the age of the PLHIV ( p = 0.002, ϕ = 0.274). There were no significant differences in the mean serum T3, T4 and TSH values among different sexes and the HIV/ART duration, however a significant difference in the mean values of TSH (F (3, 199) = 3.231, p = 0.023) and T3 (F (3, 199) = 4.587, p = 0.004) among the different age-groups were shown. The mean T3 values also indicated a gradual decrease with increasing age. Conclusion The study revealed subclinical hypothyroidism as the prevailing thyroid disorder associated with PLHIV. The risk of thyroid dysfunction in PLHIV was neither gender specific nor being attributed by the ART duration in Nepalese population; however, elderly PLHIV were highly susceptible to the risk of thyroid disorder.

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Section: Discussionsupporting

confidence: 82%

Study of thyroid dysfunction in people living with HIV in Nepalese population undergoing antiretroviral therapy: a cross-sectional study

Sah

Ansari²,

Sah³

et al. 2023

Int J STD AIDS

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“…The prevalence of thyroid abnormalities was reported to be significantly increased with further exposure to HAART [26]. In a retrospective study in Germany, subclinical disease was seen in 6% of the studied population and it correlated with duration of HAART use [27]. However, in this study, there was no correlation between length of HAART use and thyroid abnormalities.…”

Section: Discussionmentioning

confidence: 56%

Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria

Akinsete

Oyenusi

Odugbemi

et al. 2019

Journal of Thyroid Research

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Thyroid disorders have been described in an adult population but are underreported in the pediatric population. The aim of this study was to determine the prevalence and describe the spectrum of thyroid abnormalities among HIV infected children on Highly Active Antiretroviral Therapy (HAART) in Lagos, Nigeria. This was a cross-sectional study carried out at a teaching hospital with an antiretroviral therapy (ART) center. Serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) were analyzed in 83 children living with HIV on HAART and 51 controls. The prevalence of thyroid dysfunction and correlation of fT3, fT4, and TSH with duration on HAART, age, CD4 count, and nutritional status were assessed. Thyroid abnormalities were seen in 9.6% of the children living with HIV comprising subclinical hypothyroidism in 6%, euthyroid sick syndrome in 2.4%, and overt hypothyroidism in 1.2% as compared to 2% subclinical thyroid disease among the controls (p= 0.15). Hypothyroidism was correlated with CD4 count and viral load. None of the patients had clinical features of thyroid disease. Thyroid abnormalities were more prevalent among children living with HIV and yearly screening with follow-up is advocated.

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Microorganisms in Pathogenesis and Management of Hashimoto Thyroiditis

Cuan-Baltazar

Soto‐Vega

2022

Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases

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Thyroid screening in HIV-infected patients with antiretroviral therapy

Cited by 6 publications

References 26 publications

Study of thyroid dysfunction in people living with HIV in Nepalese population undergoing antiretroviral therapy: a cross-sectional study

Study of thyroid dysfunction in people living with HIV in Nepalese population undergoing antiretroviral therapy: a cross-sectional study

Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria

Microorganisms in Pathogenesis and Management of Hashimoto Thyroiditis

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