Thyroid Status and Leptin in Basedow-Graves and Multinodular Goiter Patients

Seven, Rıdvan

doi:10.1080/152873901316857752

Cited by 13 publications

(8 citation statements)

References 27 publications

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“…Our data are consistent with those from Guzel et al ., in which serum levels of leptin were significantly higher in overt and subclinical hypothyroid patients 49 . Some studies found lack of change in leptin levels with thyroid dysfunction 50 51 52 53 . For instance, thyroid dysfunction was of recent onset and patients usually presented lack of change in body mass.…”

Section: Discussionmentioning

confidence: 99%

Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

Chen

et al. 2016

Sci Rep

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Changes in profile of lipids and adipokines have been reported in patients with thyroid dysfunction. But the evidence is controversial. The present study aimed to explore the relationships between thyroid function and the profile of lipids and adipokines. A cross-sectional study was conducted in 197 newly diagnosed hypothyroid patients, 230 newly diagnosed hyperthyroid patients and 355 control subjects. Hypothyroid patients presented with significantly higher serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDLC), fasting insulin, resistin and leptin than control (p < 0.05). Hyperthyroid patients presented with significantly lower serum levels of high-density lipoprotein cholesterol, LDLC and leptin, as well as higher levels of fasting insulin, resistin, adiponectin and homeostasis model insulin resistance index (HOMA-IR) than control (p < 0.05). Nonlinear regression and multivariable linear regression models all showed significant associations of resistin or adiponectin with free thyroxine and association of leptin with thyroid-stimulating hormone (p < 0.001). Furthermore, significant correlation between resistin and HOMA-IR was observed in the patients (p < 0.001). Thus, thyroid dysfunction affects the profile of lipids and adipokines. Resistin may serve as a link between thyroid dysfunction and insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

Chen

et al. 2016

Sci Rep

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“…High levels of thyroid hormones decrease leptin expression in adipose tissue. But the most studies have not shown significant changes in leptin levels in hypothyroidism and hyperthyroidism disorders [36, 37]. However, increased leptin level in postpartum thyroiditis has been reported [38].…”

Section: Discussionmentioning

confidence: 99%

Leptin: A Correlated Peptide to Papillary Thyroid Carcinoma?

Hedayati

Yaghmaei²,

Pooyamanesh³

et al. 2011

Journal of Thyroid Research

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Introduction. Leptin as an adipose-tissue-related peptide hormone contributes to the control of food intake, energy expenditure, and other activities such as cell proliferation. Therefore, association of leptin level with thyroid cancer has been suggested recently. Considering that thyroid cancer is the most common endocrine cancer, the aim of this study was evaluation of leptin levels in thyroid cancer. Materials and Methods. 83 patients with papillary thyroid cancer (35 males and 48 females) with 90 healthy persons as control group (40 male and 50 females) were selected. serum thyroxine, thyrotropin, and leptin levels were determined in both groups. As a body fat tissue affects leptin level, so height and weight were measured and body mass index was calculated too. Results. There was no statistically significant difference in age, serum Thyroxine, and Thyrotropin levels. BMI in women was more than in men in both groups. Serum leptin levels in thyroid cancer group were significantly higher than control group (P < 0.05). Conclusion. The results of this study showed an acceptable association between the hormone Leptin levels with papillary thyroid cancer, so it may be considerad as a correlated peptide which may help in the diagnosis or confirmation of thyroid cancer beside in other specific tumor markers.

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“…In addition, leptin has been shown to improve hepatic and skeletal muscle sensitivity to insulin (113). In hyperthyroidism, circulating leptin levels have been found to be normal (116,118,(123)(124)(125) or decreased (115,126). Interestingly, leptin has been shown to increase peripheral type 2 deiodinase activity so that more T 3 is available to peripheral tissues (127,128); thus, leptin may play a role in raising levels of T 3 , thereby worsening hyperthyroidism (2).…”

Section: B Leptinmentioning

confidence: 97%

Insulin Action in Hyperthyroidism: A Focus on Muscle and Adipose Tissue

2010

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Hyperthyroidism leads to an enhanced demand for glucose, which is primarily provided by increased rates of hepatic glucose production due to increased gluconeogenesis (in the fasting state) and increased Cori cycle activity (in the late postprandial and fasting state). Adipose tissue lipolysis is increased in the fasting state, resulting in increased production of glycerol and nonesterified fatty acids. Under these conditions, increased glycerol generated by lipolysis and increased amino acids generated by proteolysis are used as substrates for gluconeogenesis. Increased nonesterified fatty acid levels are necessary to stimulate gluconeogenesis and provide substrate for oxidation in other tissues (such as muscle). In the postprandial period, insulin-stimulated glucose uptake by the skeletal muscle has been found to be normal or increased, mainly due to increased blood flow. Under hyperthyroid conditions, insulin-stimulated rates of glycogen synthesis in skeletal muscle are decreased, whereas there is a preferential increase in the rates of lactate formation vs. glucose oxidation leading to increased Cori cycle activity. In hyperthyroidism, the Cori cycle could be considered as a large substrate cycle; by maintaining a high flux through it, a dynamic buffer of glucose and lactate is provided, which can be used by other tissues as required. Moreover, lipolysis is rapidly suppressed to normal after the meal to facilitate the disposal of glucose by the insulin-resistant muscle. This ensures the preferential use of glucose when available and helps to preserve fat stores.

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Thyroid Status and Leptin in Basedow-Graves and Multinodular Goiter Patients

Cited by 13 publications

References 27 publications

Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

Leptin: A Correlated Peptide to Papillary Thyroid Carcinoma?

Insulin Action in Hyperthyroidism: A Focus on Muscle and Adipose Tissue

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