Thyroid Transplantation: Possibility of Application for the Treatment of Persistent Hypothyroidis and Study of Mechanisms of Interaction between Graft and Hypothalamic-Pituitary Axis of Recipient

Pasteur, I.P.; Тронько, Н Д; Drozdovich, I. I.; Turchin, Irina; Balla, I.

doi:10.1007/0-306-46865-4_49

Cited by 5 publications

(10 citation statements)

References 5 publications

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“…Even though all animal and human studies documented the survival and function of thyroid tissue that was implanted in muscle, the technique suffered heterogeneity of tissue preparation (some used frozen, while others used fresh tissue), implant timing, and variability of implant weight. [13][14][15][16][17][18][19][20][21][22][23][24] This work was set to study the survival and function of thyroid tissues implanted at sternomastoid muscle after total thyroidectomy in benign goiters. In this study, we compared preoperative and postoperative thyroid hormone level and TSH at 1, 3, 6, 9, and 12 months postoperatively.…”

Section: Discussionmentioning

confidence: 99%

Thyroid autotransplantation following total thyroidectomy in benign thyroid disorders: a new technique to avoid postoperative hypothyroidism

et al. 2019

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Background: Although total thyroidectomy has become the operation of choice in treatment of BMNG, it leads to permanent hypothyroidism which lead the patient to take a lifelong exogenous hormone replacement therapy, which involves daily administration of levothyroxine at a dose that must be in close follow-up in terms of thyroid hormone levels. In addition, reaching euthyroid status using hormone replacement therapy can be affected in presence of other medical problems that interfere with absorption of the drug as mal-absorption syndrome. When all these are considered, there is a necessity of a novel method to avoid the occurrence of postoperative hypothyroidism.Methods: A case series prospective study carried out over 30 patients with benign thyroid disorders for whom total thyroidectomy is indicated to evaluate the capacity of auto-implanted thyroid tissue in achieving an euthyroid state without any need for life-long hormone replacement therapy. Postoperative Assessment consists of repeated thyroid function tests and thyroid scan with complementary SPECT/CT.Results: significant gradual increase in serum levels of T3 and T4 with corresponding decrease in TSH levels returning to normal levels 6-9 months postoperatively. Thyroid scan with complementary SPECT/CT was done for 15 patients to evaluate the functional capacity of the thyroid implant. Among the 15 patients, 13 patients have functioning thyroid implant (success percent: 6.6%). whereas 2 patients show non functioning thyroid implant (failure percent: 13.3%).Conclusions: Thyroid Auto-transplantation following total thyroidectomy in benign thyroid disorders is an effective method to prevent postoperative hypothyroidism.

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Section: Discussionmentioning

confidence: 99%

Thyroid autotransplantation following total thyroidectomy in benign thyroid disorders: a new technique to avoid postoperative hypothyroidism

et al. 2019

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“…Another large study was done by Pasteur et al [ 47 ] in Ukraine in 1999, for developing a new culture technique to achieve the highest activity of newborn pig thyroid tissue hormones and preserve the morphological and other functional characteristics of thyroid follicles. The study showed that during culturing of the thyroid tissue of newborn pig, the morphological and functional features of thyrocytes are preserved for a period of 1 month.…”

Section: Animal Experimentsmentioning

confidence: 99%

Review of Heterotopic Thyroid Autotransplantation

Sakr

Mahmoud

2017

Clin Exp Otorhinolaryngol

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Total thyroidectomy is increasingly accepted for the management of bilateral benign thyroid disorders. Postoperatively, patients require lifelong levothyroxine replacement therapy to avoid postoperative hypothyroidism, which besides the burden of compliance, has been proven to be associated with several long-term side effects. Heterotopic thyroid autotransplantation was proposed several decades ago to avoid the need for life-long postoperative replacement therapy with maintaining the autoregulatory mechanism of thyroxin production inside the body according to its needs. Available data regarding this topic in literature is relatively poor. Before applying thyroid autotransplantation on humans, several studies have been done on animals, where the autologous transplantations were found to be successful in almost all the cases, proved by follow up postoperative 8-week measurements of thyroid hormones and histopathological examination of the removed autografts. Regarding the clinical application, few trials have been done using cryopreserved in vivo, in vitro or immediately autotransplanted thyroid autografts. Satisfactory results were obtained, however, the number of these studies and the number of patients per each study was very low. Besides the study methodologies were not so consistent.

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“…Each male Wistar rat (weight of rats: 100-150 g) received the dose of 75.0 µCi of 131-iodine by intraperitoneal injection. Newborn pig thyroid organ culture was obtained as previously described (Pasteur et al, 1999). The XTP of 3-day-old thyroid organ culture was performed on day 18 after radioactive ablation by injection into the fat tissue of anterior abdominal wall.…”

Section: Transplantation Of Cultured Newborn Pig Thyroid Tissuementioning

confidence: 99%

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Pasteur¹,

Тронько²,

Drozdovich³

et al. 2000

Cytotechnology

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The aim of the present study was to develop atransplantation technique for restoration of thyroidfunction in rats with radioiodine-inducedhypothyroidism. Each Wistar rat received the dose of75.0 muCi of 131-iodine by intraperitonealinjection. The serum thyroxine and triiodothyroninevalues in all rats fell to low levels by 2.5 weeksafter radioiodine administration. Thexenotransplantation of 3-day-old newborn pig thyroidorgan culture was performed on day 18 afterradioactive ablation by injection into the fat tissueof anterior abdominal wall. Epithelial cell swarmswith follicular formation manifested themselves amongadipose tissue on day 7 as well as day 17 afterxenotransplantation. The serum thyroxine andtriiodothyronine values in the rats were generallywithin the euthyroid range by day 7-17 afterxenotransplantation. The thyroid gland of ratsreverted to the norm in morphofunctional appearance.These results indicated that the xenografted newbornpig thyroid organ culture allowed a restoration of thyroid function in Wistar rats with post-radioiodine hypothyroidism.

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Thyroid Transplantation: Possibility of Application for the Treatment of Persistent Hypothyroidis and Study of Mechanisms of Interaction between Graft and Hypothalamic-Pituitary Axis of Recipient

Cited by 5 publications

References 5 publications

Thyroid autotransplantation following total thyroidectomy in benign thyroid disorders: a new technique to avoid postoperative hypothyroidism

Thyroid autotransplantation following total thyroidectomy in benign thyroid disorders: a new technique to avoid postoperative hypothyroidism

Review of Heterotopic Thyroid Autotransplantation

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