Tibial bone density, cross‐sectional geometry and strength in Finnish pet rabbits: a peripheral quantitative computed tomography study

Mäkitaipale, Johanna; Sievänen, Harri; Laitinen‐Vapaavuori, Outi

doi:10.1136/vr.104419

Cited by 10 publications

(6 citation statements)

References 45 publications

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“…Rabbits provide a more relevant size to evaluate some human orthopedic implants, as well as an appropriate size to be maintained long-term so that revision procedures can be performed. Rabbits also provide a more similar immune system and long bone density to humans than mice and rats provide ( 143 , 144 ). Despite these benefits, rabbit models are accompanied by more complex challenges including respiratory depression under anesthesia, hindgut fermentation, which impacts the ability to assess oral antibiotic therapies, and variation in bone healing response of young rabbits compared to humans.…”

Section: Discussionmentioning

confidence: 99%

Role of Animal Models to Advance Research of Bacterial Osteomyelitis

Billings

Anderson

2022

Front. Vet. Sci.

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Osteomyelitis is an inflammatory bone disease typically caused by infectious microorganisms, often bacteria, which causes progressive bone destruction and loss. The most common bacteria associated with chronic osteomyelitis is Staphylococcus aureus. The incidence of osteomyelitis in the United States is estimated to be upwards of 50,000 cases annually and places a significant burden upon the healthcare system. There are three general categories of osteomyelitis: hematogenous; secondary to spread from a contiguous focus of infection, often from trauma or implanted medical devices and materials; and secondary to vascular disease, often a result of diabetic foot ulcers. Independent of the route of infection, osteomyelitis is often challenging to diagnose and treat, and the effect on the patient's quality of life is significant. Therapy for osteomyelitis varies based on category and clinical variables in each case. Therapeutic strategies are typically reliant upon protracted antimicrobial therapy and surgical interventions. Therapy is most successful when intensive and initiated early, although infection may recur months to years later. Also, treatment is accompanied by risks such as systemic toxicity, selection for antimicrobial drug resistance from prolonged antimicrobial use, and loss of form or function of the affected area due to radical surgical debridement or implant removal. The challenges of diagnosis and successful treatment, as well as the negative impacts on patient's quality of life, exemplify the need for improved strategies to combat bacterial osteomyelitis. There are many in vitro and in vivo investigations aimed toward better understanding of the pathophysiology of bacterial osteomyelitis, as well as improved diagnostic and therapeutic strategies. Here, we review the role of animal models utilized for the study of bacterial osteomyelitis and their critically important role in understanding and improving the management of bacterial osteomyelitis.

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Section: Discussionmentioning

confidence: 99%

Role of Animal Models to Advance Research of Bacterial Osteomyelitis

Billings

Anderson

2022

Front. Vet. Sci.

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“…As mentioned by Mäkitaipale et al [ 54 ], the growing rabbits have a high bone growth rate and their bone density is positively proportional with the age of the rabbit. So, for evaluation of the AOI density at each time-point, the measurement of the normal bone density was a must at each time-point where a significant increase in the density of the normal bone was observed and the AOI in the PRF/ZnONPs group had restored the normal density as early as the second month of the study.…”

Section: Discussionmentioning

confidence: 99%

Does zinc oxide nanoparticles potentiate the regenerative effect of platelet-rich fibrin in healing of critical bone defect in rabbits?

et al. 2022

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Background Many encouraging studies confirmed the ability of Zinc Oxide Nanoparticles (ZnONPs) in accelerating bone growth and mineralization. The use of Platelet Rich-Fibrin (PRF) as a sole filling material for large segmental bone defects remains questionable. The objectives are to investigate the regenerative efficacy of autologous Platelet Rich-Fibrin (PRF) and Zinc Oxide Nanoparticles (ZnONPs) in repairing large segmental bone ulnar defects in a randomized controlled study in rabbits using computed tomographic interpretations. A 12 mm critical size defect was surgically induced in the ulna of 30 rabbits (n = 10/ group). In the control group, the defect was left empty. In the PRF group, the defect is filled with PRF. In the PRF/ZnONPs group, the defect is filled with PRF that was inoculated with 0.1 ml of 0.2% ZnONPs. Radiologic healing capacity was evaluated at the first, second, and third postoperative months. Results Statistical analysis showed significant differences in the radiologic healing scores between the groups (P = 0.000–0.0001) at all-time points (P = 0.000–0.047) during the study. Conclusion Rabbits in the PRF/ZnONPs group showed the highest appreciable bone quality and quantity followed by the PRF group with high quantity but low bone quality meanwhile, rabbits in the control group showed minimal quantity but medium bone quality. Interestingly, the addition of ZnONPs to PRF can accelerate the healing of ulnar critical-size defects in rabbits.

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“…Castration is known to increase the risk of osteoporosis and associated fractures in men treated for prostate cancer (Daniell et al 2000). However, the impact of neutering on the bone strength of male CGR rabbits is unknown, although neutering appears to have no impact on trabecular or cortical bone density of the tibia in rabbits (Mäkitaipale et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Femoral condylar fractures in four continental giant breed rabbits

Dorlis

Garcia-Pertierra

Richardson

et al. 2021

J of Small Animal Practice

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Four male neutered continental giant rabbits aged between 10 and 30 months were presented with femoral condylar fractures, which developed without an observed traumatic injury. Stabilisation of the condylar fracture was achieved with screw fixation in all cases, which was supplemented with additional fixation in three cases. Complications consequent to the surgical intervention occurred in two cases: a femoral fracture and loss of fixation. Three rabbits were reported to have recovered normal limb function, and the rabbit that developed a femoral fracture as a consequence of its surgical intervention was treated with amputation.

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Tibial bone density, cross‐sectional geometry and strength in Finnish pet rabbits: a peripheral quantitative computed tomography study

Cited by 10 publications

References 45 publications

Role of Animal Models to Advance Research of Bacterial Osteomyelitis

Role of Animal Models to Advance Research of Bacterial Osteomyelitis

Does zinc oxide nanoparticles potentiate the regenerative effect of platelet-rich fibrin in healing of critical bone defect in rabbits?

Femoral condylar fractures in four continental giant breed rabbits

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