Tigecycline is the First Clinically-Available Drug in a new class of Antibiotics called the Glycylcyclines: A Review

Jain, Mayur Shirish; Barhate, Shashikant D.

doi:10.5958/2231-5713.2020.00010.0

Cited by 3 publications

(1 citation statement)

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“…In 2018, 22.0% K. pneumoniae isolated from Ramadi hospitals were resistant for carbapenem . Genotypic testing on six CRE isolates revealed that the blaOXA-48 and blaVIM genes were equally detected in these isolates, followed by blaKPC ( 23) , (28). Moreover, Mohammed and Safaa reported blaFOX11 (42.3%), blaACC8 (30.7%), blaDHA 8 (30.7%), blaCIT 9(34.6%) and blaMOX 7 (26.92%) (29).…”

Section: Detection Of Blatem Genementioning

confidence: 99%

Molecular Screening of Extended Spectrum β-lactamases in Klebsiella pneumoniae isolated from Clinical Sources

Jassim¹,

Hassan²

2022

Journal of Pharmaceutical Negative Results

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Klebsiella pneumoniae is a major pathogen responsiple for nosocomial infections in world hospitals . One of the causes for the drug resistance in the Klebsiella pneumoniae is the production of ESBls enzymes.This research documented TEM , SHV , and CTX-M for the first time among Klebsiella pneumoniae in Al-Anbar hospitals of Iraqi. All studied clinical isolates of K. pneumoniae (30) resistant- beta lactam from 100 isolates were collected from different clinicals sources such as (burned, wounds, sputum,and urine samples). The susceptibility to different antibiotics was tested by VITEK-2 system. The bla TEM , SHV , and CTX-M genes were detected by conventional PCR and the result showed 30/30 (100%) strains harbored these genes. This results showed the coexistence of these genes in one strains of K. pneumoniae, while indicated widespread ESBLs in Anbar, Iraq.

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Section: Detection Of Blatem Genementioning

confidence: 99%

Molecular Screening of Extended Spectrum β-lactamases in Klebsiella pneumoniae isolated from Clinical Sources

Jassim¹,

Hassan²

2022

Journal of Pharmaceutical Negative Results

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Study the Epidemiology of Antibiotics Resistance in Ramadi Hospitals of Iraq

Najeeb

Meani

Abdulkareem

et al. 2022

RJPT

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In many hospitals around the world, antibiotic resistance has reached a crisis. Mainly, Staphylococcus aureus (MRSA), which is immune to methicillin, is swamped and many with Gram-negative multidrug-resistant (MDR). The occurrence of carbapenmases for the first time was considered a major problem because of several factors, such as: many plasmids carrying gene resistance elements take on other resistance elements, including QnrA (QnrA and QnrB) and aminoglycoside (rmtB) Resistance elements. For severe MRSA infections, good treatment options are available, death rates continue to be high. The condition is more complicated and disturbing for MDR Gram-negatives. In developing countries, there are few new agents who can profit from the situation in the coming decade . Although the meanings are muddled, some patients in intensive care are thought to die because of the lack of antibiotics effective against Pseudomonas aeruginosa and A. baumanni. If molecular resistance is to be overcome, additional understanding is needed urgently. We additionally need to install early warning systems to keep pace with new resistances.

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In Vitro and In Vivo Effect of Oxytetracycline on Sperm Parameters In Breeding Rooster

Mohammedi,

Messai,

Touazi

et al. 2023

cryo letters

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BACKGROUND: Some antimicrobials could adversely affect sperm quality during sperm cryopreservation and antibiotic treatment with subsequent effects on fertility outputs. To our knowledge, no similar studies have been conducted on breeding roosters, especially for oxytetracycline (OTC). OBJECTIVE: To investigate both in vitro and in vivo impact of oxytetracycline on sperm parameters in breeding roosters. METHODS: Sperm motility parameters were objectively analyzed using the CASA system including total motility (TM %), progressive motility (PM %), all sperm velocities, the sperm count, and cell viability during 9 days of in vivo treatment. In the in vitro investigation, the pooled sperm was diluted and divided into a control aliquot (diluted in 0.9% NaCl) and treated samples. Motility parameters were assessed after 0, 1, 2, 3, 4, 5, and 6 hours of storage at 37ºC. In the in vivo study, 1 g/L of OTC was administrated to five individuals for nine consecutive days. Fresh semen samples were analyzed at T0 (before treatment) and after 6 (T6) and 9 days (T9) of treatment. RESULTS: OTC caused significant impairment of sperm quality in vivo. A drastic reduction in sperm concentration, viability, TM, PM, and all kinematic parameters was observed after 6 days of treatment. However, at day 9 sperm quality had improved to be nearly similar to T0. In vitro, OTC induced similar sperm impairment on all sperm motility parameters. CONCLUSION: Oxytetracycline exhibited negative effects on rooster sperm both in vivo and in vitro and appears consequently not suitable in cryopreservation extenders.

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Tigecycline is the First Clinically-Available Drug in a new class of Antibiotics called the Glycylcyclines: A Review

Cited by 3 publications

References 0 publications

Molecular Screening of Extended Spectrum β-lactamases in Klebsiella pneumoniae isolated from Clinical Sources

Molecular Screening of Extended Spectrum β-lactamases in Klebsiella pneumoniae isolated from Clinical Sources

Study the Epidemiology of Antibiotics Resistance in Ramadi Hospitals of Iraq

In Vitro and In Vivo Effect of Oxytetracycline on Sperm Parameters In Breeding Rooster

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