Tiger nut oil-based diet improves the lipid profile and antioxidant status of male Wistar rats

Ibitoye, O.B.; Aliyu, Najeeb O.; Ajiboye, Taofeek O.

doi:10.1111/jfbc.12587

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…Consumption of plant‐based foods is on the increase (Ibitoye, Aliyu, & Ajiboye, ) because of awareness of their health benefits and bioactive constituents such as polyphenols and micro‐ and macronutrients (Ibitoye, Olofinsan, et al, ; Oloyede et al, ). In this study, we present gallic and protocatechuic acids as the α‐amylase and α‐glucosidase inhibitory principles in H. sabdariffa calyx.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

et al. 2019

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We isolated and identified gallic and protocatechuic acids as the antidiabetic principles in Hibiscus sabdariffa using solvent extraction, column chromatographic fractionation, and nuclear magnetic resonance (NMR) spectroscopy. Ethylacetate fraction of the aqueous extract of H. sabdariffa inhibited α‐amylase and α‐glucosidase with IC50 of 411.73 and 433.93 μg/ml, respectively. Furthermore, fractions I and II obtained from column chromatography inhibited α‐amylase with IC50 of 27.03 and 20.12 μg/ml, and α‐glucosidase with IC50 of 24.30 and 22.29 μg/ml, respectively. In addition, the principles reduced the serum glucose and lipid peroxide levels of diabetic rats and with an improvement in the rat lipid profiles and antioxidant defenses. Fractions I and II were identified as protocatechuic acid and gallic acid, respectively, using 1H and 13C NMR. Protein–ligand docking showed that these compounds form multiple favorable interactions with the active‐site residues of the two glycosidases. Overall, protocatechuic and gallic acids emerge as natural antidiabetic agents. Practical applications Hibiscus sabdariffa (Zoborodo) is a refreshment drink for ceremonial gatherings in Nigeria. Also, its pharmacological use includes diabetes, hypertension, hyperlipidemia, metabolic syndrome, and hepatoprotection. The consumption of this food drink could improve diabetes, hypertension, dyslipidemia, metabolic syndrome, and liver disease. Furthermore, the inhibition of α‐amylase and α‐glucosidase could prevent diabetic complications associated with postprandial glucose. Developing the extract of H. sabdariffa calyx as food supplement could be used in managing diabetes and its associated complications such as dyslipidemia, hypertension, and metabolic syndrome.

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Section: Resultsmentioning

confidence: 99%

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

et al. 2019

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“…Therefore, the capacity of tiger nut to counteract the effect of H 2 O 2 may suggest that the antioxidant capacity, mainly ascribed to its polyphenol and α-tocopherol contents [ 8 ], could also be responsible for the recovery of epithelial barrier function induced by oxidative stress. Along these lines, there have been descriptions of an increase in reduced glutathione in the liver, kidney, and heart among rats fed a diet based on tiger nut oil [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Cyperus esculentus L. Tubers (Tiger Nuts) Protect Epithelial Barrier Function in Caco-2 Cells Infected by Salmonella Enteritidis and Promote Lactobacillus plantarum Growth

et al. 2020

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Cyperus esculentus L. tubers (tiger nuts) contain different compounds with several intestinal health-promoting properties. Here, we studied the capacity of tiger nuts from Valencia, Spain, to prevent epithelial barrier function disruption induced by Salmonella enteritidis in Caco-2 cell cultures. Paracellular permeability was assessed by transepithelial electrical resistance (TER) and tight junction protein immunolocalization. Moreover, the effect of tiger nuts on S. enteritidis agglutination, oxidative stress, and Lactobacillus plantarum growth was tested. Compared to controls, tiger nuts partially restored TER in S. enteritidis-infected cultures, an effect confirmed by immunolocalization of tight junction proteins ZO-1 and occludin. The results also revealed that this protective effect may be associated with the capacity to agglutinate the pathogen, restore TER in TNFα-stimulated cultures, and reduce reactive oxygen species in H2O2-stimulated cultures. Moreover, they favor L. plantarum growth. In conclusion, this study demonstrates that the tiger nut protects epithelial barrier function by reducing bacterial invasion, along with counteracting TNFα and H2O2 effects, thus giving an additional value to this tuber as a potential functional food.

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“…The results showed that the mixed oil resulted in a lower serum cholesterol level of rats compared with the control. Ibitoye et al studied the influence of tiger nut oil and soybean oil on the lipid profile of male Wistar rats [ 41 ]. They found that rats fed with tiger nut oil displayed a lower level of the total cholesterol, triglycerides, low-density lipoprotein cholesterol and higher levels in the high-density lipoprotein cholesterol and glutathione compared with that of rats fed with soybean oil.…”

Section: Tiger Nut Oilmentioning

confidence: 99%

Tiger Nut (Cyperus esculentus L.): Nutrition, Processing, Function and Applications

Zhang

et al. 2022

Foods

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The tiger nut is the tuber of Cyperus esculentus L., which is a high-quality wholesome crop that contains lipids, protein, starch, fiber, vitamins, minerals and bioactive factors. This article systematically reviewed the nutritional composition of tiger nuts; the processing methods for extracting oil, starch and other edible components; the physiochemical and functional characteristics; as well as their applications in food industry. Different extraction methods can affect functional and nutritional properties to a certain extent. At present, mechanical compression, alkaline methods and alkali extraction–acid precipitation are the most suitable methods for the production of its oil, starch and protein in the food industry, respectively. Based on traditional extraction methods, combination of innovative techniques aimed at yield and physiochemical characteristics is essential for the comprehensive utilization of nutrients. In addition, tiger nut has the radical scavenging ability, in vitro inhibition of lipid peroxidation, anti-inflammatory and anti-apoptotic effects and displays medical properties. It has been made to milk, snacks, beverages and gluten-free bread. Despite their ancient use for food and feed and the many years of intense research, tiger nuts and their components still deserve further exploitation on the functional properties, modifications and intensive processing to make them suitable for industrial production.

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Tiger nut oil-based diet improves the lipid profile and antioxidant status of male Wistar rats

Cited by 6 publications

References 34 publications

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

Cyperus esculentus L. Tubers (Tiger Nuts) Protect Epithelial Barrier Function in Caco-2 Cells Infected by Salmonella Enteritidis and Promote Lactobacillus plantarum Growth

Tiger Nut (Cyperus esculentus L.): Nutrition, Processing, Function and Applications

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