Tight junctions and bladder cancer (Review)

Haynes, Mark D.; Martin, Tracey Amanda; Jenkins, S. A.; Kynaston, Howard; Matthews, P. N.; Jiang, Wen Guo

doi:10.3892/ijmm.16.1.3

Cited by 18 publications

(21 citation statements)

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“…A growing literature indicates that changes in claudin expression may alter the metastatic potential of numerous tumor types (199), and alterations in expression of tight junction proteins may also play an important role in the genesis of bladder cancer (84). Furthermore, disruptions of tight junctions may contribute to bladder conditions such as outlet obstruction, bacterial cystitis, spinal cord injury, and interstitial cystitis (IC), all of which are characterized by alterations of the uroepithelium and umbrella cell junctional complex (12,106,119,127,128,149,213,215,237).…”

Section: Paracellular and Transcellular Ion Solute And Water Transpmentioning

confidence: 99%

Cell biology and physiology of the uroepithelium

Khandelwal

Abraham

Apodaca

2009

American Journal of Physiology-Renal Physiology

313

339

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The uroepithelium sits at the interface between the urinary space and underlying tissues, where it forms a high-resistance barrier to ion, solute, and water flux, as well as pathogens. However, the uroepithelium is not simply a passive barrier; it can modulate the composition of the urine, and it functions as an integral part of a sensory web in which it receives, amplifies, and transmits information about its external milieu to the underlying nervous and muscular systems. This review examines our understanding of uroepithelial regeneration and how specializations of the outermost umbrella cell layer, including tight junctions, surface uroplakins, and dynamic apical membrane exocytosis/endocytosis, contribute to barrier function and how they are co-opted by uropathogenic bacteria to infect the uroepithelium. Furthermore, we discuss the presence and possible functions of aquaporins, urea transporters, and multiple ion channels in the uroepithelium. Finally, we describe potential mechanisms by which the uroepithelium can transmit information about the urinary space to the other tissues in the bladder proper.

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Section: Paracellular and Transcellular Ion Solute And Water Transpmentioning

confidence: 99%

Cell biology and physiology of the uroepithelium

Khandelwal

Abraham

Apodaca

2009

American Journal of Physiology-Renal Physiology

313

339

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“…TJs are comprised of transmembrane proteins such as occludin, claudin, and junctional adhesion molecule and cytoplasmic proteins including zona occludens (ZO)-1, -2, -3, cingulin, and 7H6 (22). Loss of TJ function and loss of cell-to-cell adhesion accompanies the dedifferentiation of primary tumor cells into an invasive phenotype (23). Decreased levels of TJ proteins ZO-1, occludin, and claudin-4 have been reported in metastatic tumors including colorectal tumors with liver metastasis (24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

Cell-Free Supernatants from ProbioticLactobacillus caseiandLactobacillus rhamnosusGG Decrease Colon Cancer Cell Invasion In Vitro

Escamilla

Lane

Maitin

2012

Nutrition and Cancer

151

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“…In human bladder uroepithelium, an alteration of TJs during cancer progression has been recognized as a potential therapeutic target. 4 Specifically, CAR-1 can elicit a negative signal cascade to modulate the cell cycle regulators of bladder cancer cells. 16,18,19 CAR-1 might negatively regulate the proliferation of adult bladder uroepithelium.…”

Section: Commentmentioning

confidence: 99%

“…Furthermore, in the human uroepithelium, bacterial cystitis, interstitial cystitis, hypercalciuria spinal cord injury, and cancer alter the permeability of the paracellular barrier. [3][4][5] To date, several different TJ proteins have been identified in the bladder uroepithelium. [6][7][8][9] One such TJ protein is coxsackievirus and adenovirus receptor (CAR), a member of the Ig-type superfamily of cell adhesion molecules.…”

mentioning

confidence: 99%