Tight Mechanism Correlation Between Heart Rate Turbulence and Baroreflex Sensitivity: Sequential Autonomic Blockade Analysis

Abstract

Heart rate turbulence of turbulence onset and turbulence slope is critically vagal dependent and highly correlated with spontaneous baroreflex sensitivity, which underscores its clinical importance in cardiovascular risk stratification.

Demonstration of circadian rhythm in heart rate turbulence using novel application of correlator functions

“…Instead, betablockade likely affects HRT values indirectly by reducing VPC frequency and heart rate. It should be noted that acute beta blockade did not affect HRT values in an induced HRT study (34), and that the effectiveness of HRT as a risk predictor has remained high despite increases in betablocker usage over the years. Finally, beta 14 blocker therapy has been shown to increase TS along with left ventricular ejection fraction in patients with congestive heart failure (35), demonstrating that betablockers can influence HRT.…”

“…Vagal outflow is the predominant determinant of heart rate, and appears to be the predominant determinant of HRT (6,34) as well. It is difficult to think of a physiological dependence of HRT on heart rate that is unrelated to their mutual dependence on baseline autonomic tone.…”

Could decreased vitamin D levels be related with impaired cardiac autonomic functions in patients with chronic heart failure: An observational study

“…Beta-blockers inhibit sympathetic activity and improve HRV (32, 33) also angiotensin converting enzym inhibitors and angio- Statistics were done using by қ 2 , in this table. NS -not significant; IDKMP -ischemic dilated cardiomyopathy; NIDCM -non-ischemic dilated cardiomyopathy; SDNN -standard deviation of all normal-to-normal RR intervals; SDANN -standard deviation of the average normal to normal interval; RMSSD -squares of the differences between adjacent normal-to-normal RR intervals; TO -turbulence onset; TS -turbulence slope tensin receptor blockers enhance the vagal stimulations and baroreflex sensitivity so that positively effects HRV and HRT (34,35). In our study, the number of patients who were using angiotensin-II antagonist and digoxin were much more in NIDCM group and the number of patients using aspirin, statins and nitrates were much more in IDCM group than the other group.…”

A New Cardiac Autonomic Function Predictor (Heart Rate Turbulence) in Patients with Ankylosing Spondylitis

“…BRS and HRT, which are some of the noninvasive prognostic factors showing cardiac autonomic activity, can determine cardiovascular death with associated arrhythmia (27). HRT is interrelated with spontaneous BRS and it may be used in its place as a new diagnostic method (27). It is proven that HRT also predicts mortality and sudden cardiac death in various cardiac abnormalities (14,(28)(29)(30).…”