The petrography and mineral chemistry of magnetite and hematite from igneous, metasedimentary, and sedimentary bedrock in the area of the Kiggavik unconformity-related uranium deposit, and from till covering the deposit were investigated using optical microscopy, scanning electron microscopy (SEM), electron probe micro-analyzer (EPMA), and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The R-package rob-Compositions method was used to treat censored values in the EPMA and LA-ICP-MS geochemical data, and the results were transformed using a centered log-ratio transformation prior to data analysis using partial least squares-discriminant analysis (PLS-DA). The Kiggavik rock samples are from a wide range of lithologies including granite, leucogranite, syenite, metagreywacke, quartzite, and quartz arenite. The integration of petrography and mineral chemistry identifies four origins for iron oxides in the Kiggavik bedrocks: magmatic, hydrothermal, diagenetic, and weathering. The igneous bedrocks mainly contain magmatic magnetite replaced by mostly hydrothermal and rarely by weathering related hematite. Higher concentrations of trace elements such as Mg, Al, Ti, and Zr in hydrothermal hematite from leucogranite, granite and Martell syenite relative to parent magnetite suggest that hematite crystallized from high-temperatures hydrothermal fluids. By contrast, relative trace elements depletion in hematite replacing V-Cr-rich magnetite from Schultz Lake Intrusive Complex syenite may indicate hematite precipitation from low-temperature oxidizing fluids. The high U content (450 ppm averagely), rounded shape, and altered edges of hematite grains from metagreywacke indicate that the iron oxide is detrital, originally precipitated from U-rich hydrothermal fluids. Quartzite also contains hydrothermal hematite. Distinct chemical compositions of hydrothermal hematite from Kiggavik metasedimentary and igneous basement demonstrate different compositions and temperatures of parental hydrothermal fluids, as well as different compositions of replaced minerals/host rocks.