Time and Dose Dependent Effects of Continuous Consumption of Monosodium Glutamate on Organ Histology (Kidney and Liver), Haematological and Biochemical Profiles of Albino Wistar Rats.

Halilu, Tilako B.; Ernest, Ukaejiofo O.; Otuu, Fred C.; Obi-Ezeani, Nwando Chikaodili; Nwodo, Sunday E.; Ilouno, Lawrence; Amazu, Louis U; Shu, En; Ifeoma, Inya-Agha Stella; Christopher, Okechukwu C.

doi:10.9790/2402-1101035064

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“…3 Feeding of MSG at a dose of 6 g/kgb.wt for 21 days gives a picture of vacuolization, the presence of necrosis cells and inflammatory cells in the pericellular channels of rat hepar. 4 The toxic effect on the liver is due to the activity of free radical compounds from MSG. 1 The toxic effects due to free radicals from MSG can be overcome by the body in the presence of endogenous antioxidants or antioxidants that come from within the body.…”

Section: Introductionmentioning

confidence: 99%

Effect of Tiger Shrimp Shell Extract (Penaeus monodon) on Monosodium Glutamate-Induced Mice

Saraswati,

Armalina,

Ayu

et al. 2023

dmj

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Background: The shell is a part of the tiger shrimp (Penaeus monodon) body that often becomes waste and has not been utilized properly, but it contains secondary antioxidants that can prevent oxidative stress in the form of astaxanthin. Although several studies have examined the function of astaxanthin as an antioxidant, the role of it in tiger shrimp shells against hepar mice induced by monosodium glutamate (MSG) is not well knownObjective: to determine the effect of tiger shrimp shell extract in graded doses on the histopathological picture of hepatic mice induced by MSG.Methods: Extraction of tiger shrimp shell was carried out with palm head oil solvent and analyzed with Ultraviolet-Visible spectrophotometer (UV-Vis). This study used 25 male mice classified into 5 groups. One group was negative control without any need and 4 other groups were induced with MSG 0.84 g/kgBB. Three of the MSG-induced groups were induced with tiger shrimp shell extract at doses of 50 mg/kgBB, 100 mg/kgBB, and 200 mg/kgBB. The treatment was given for 35 days. Mice were terminated on the 42nd day and hepatic histopathology was observed with Manja Roenigk score.Results: The group induced with tiger shrimp shell extract in graded doses showed a better picture of hepatic histology structure compared to the group that was only induced with MSG. Statistical tests using the Kruskal Wallis test showed a significant difference between each group with a P value of 0.005.Conclusion: Feeding of tiger shrimp shell extract in graded doses can prevent hepatic damage to MSG-induced mice.

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Section: Introductionmentioning

confidence: 99%