Time Course of Antioxidant Enzyme Activities in Liver Transplant Recipients

Hassan, Laila; Bueno, Pablo; Ferrón-Celma, I.; Ramia, J. M.; Garrote, Daniel; Muffak, Karim; García-Navarro, Ana; Mansilla, Alfonso; Villar, Jesús; Ferrón, José Antonio

doi:10.1016/j.transproceed.2005.10.088

Cited by 36 publications

(25 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Its sensitivity to diagnose HCV patients was 100%, while in HBV and schistosomiasis the sensitivity levels were 16.7% and 17.7% respectively, at a specificity level of 93.3%. These results are in accordance with the findings of previous studies [25][26][27] that GR was highly specific for GSSG and could be used in the detection of liver injury. So the increased activity of GR in our study could be explained by the fact that the increased production of reactive oxygen metabolites might be actively scavenged by GSH, resulting in the formation of GSSG, which is rapidly converted to GSH by GR.…”

Section: Discussionsupporting

confidence: 93%

“…Hydroxyl radicals may react by either hydroxylation or hydrogen abstraction, setting off free-radical chain reactions that subsequently increases MDA concentration [26,34]. To sum up, our results agree with other studies that have shown increased MDA level and changes in activities of GSHrelated enzymes [27]. These findings indicate that the glutathione antioxidant system is imbalanced in hepatocellular damage, and they support the hypothesis that oxidative stress plays an important role in the development of these liver diseases.…”

Section: ،٤ ‫ﺍﻟﻌﺪﺩ‬ ‫ﻋﴩ،‬ ‫ﺍﳋﺎﻣﺲ‬ ‫ﺍﳌﺠﻠﺪ‬ ‫ﺍﻟﻌﺎﳌﻴﺔ،‬ ‫ﺍﻟﺼﺤﺔ‬ ‫ﻣﻨsupporting

confidence: 92%

See 1 more Smart Citation

Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children

Mahdy¹,

Abd-El-Shaheed²,

Khadr³

et al. 2009

East Mediterr Health J

View full text Add to dashboard Cite

Serum levels of glutathione reductase (GR), glutathione S-transferase-α (GST-α) and malondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. Except for level of GR in patients with HBV, GR, GST-α and MDA were raised significantly in patients compared with controls. At 100% specificity, the sensitivity of the 3 markers for detecting hepatitis B virus, hepatitis C virus and schistosomiasis infection respectively were: 16.7%, 100.0% and 17.7% for GR; 33.3%, 62.1% and 38.2% for GST-α; and 25.0%, 10.3% and 29.4% for MDA. GR was more sensitive in hepatitis C infection, while MDA reflected changes in liver ultrasound and GST-α was the best indicator for histopathological changes. Rôle du statut antioxydant et du processus de péroxydation des lipides dans l'évaluation des lésions hépatocellulaires chez l'enfant RÉSUMÉ Nous avons déterminé les taux sériques de glutathion-réductases (GR), d'α-glutathion-Stransférases (α-GST) et de malondialdéhyde (MDA) afin d'évaluer leur rôle dans le diagnostic des lésions hépatocellulaires chez 75 enfants souffrant d'une maladie hépatique. À l'exception du taux de GR chez les patients atteints du virus de l'hépatite B (VHB), les taux de GR, d'α-GST et de MDA étaient significativement plus élevés chez les malades que chez les témoins. Avec une spécificité de 100 %, la sensibilité des trois marqueurs pour le dépistage du VHB, du VHC et de la schistosomiase était respectivement de 16,7 %, 100,0 % et 17,7 % pour les GR ; de 33,3 %, 62,1 % et 38,2 % pour les α-GST ; et de 25,0 %, 10,3 % et 29,4 % pour le MDA. Les GR étaient plus sensibles dans le cas de l'infection par le VHC, alors que le MDA témoignait de changements à l'échographie du foie et que les α-GST étaient le meilleur indicateur des changements histopathologiques.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: ،٤ ‫ﺍﻟﻌﺪﺩ‬ ‫ﻋﴩ،‬ ‫ﺍﳋﺎﻣﺲ‬ ‫ﺍﳌﺠﻠﺪ‬ ‫ﺍﻟﻌﺎﳌﻴﺔ،‬ ‫ﺍﻟﺼﺤﺔ‬ ‫ﻣﻨsupporting

confidence: 92%

Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children

Mahdy¹,

Abd-El-Shaheed²,

Khadr³

et al. 2009

East Mediterr Health J

View full text Add to dashboard Cite

show abstract

“…Among them, LPO is a free radical-related process (30). One of the main end products of LPO is MDA, which is characterized by cross-linking cellular macromolecules such as protein or DNA and induces widespread cellular damage (31). The results in Figure 2A showed that ET and quercetin isolated from L. christinae significantly inhibited alcohol-induced excessive amounts of MDA, indicating that ET and quercetin can prevent alcohol-induced LPO injury in liver.…”

Section: Discussionmentioning

confidence: 97%

Protective effect of Lysimachia christinae against acute alcohol-induced liver injury in mice

Wang

Zhang

et al. 2012

Biosci Trends

View full text Add to dashboard Cite

“…Free radical ablation for the treatment of reperfusion injury has found its first clinical application in the prevention of postischemic hepatic failure following liver transplantation. Thus, agents proposed to be useful in the clinical setting of hepatic I/R damage includes free radical scavengers [7] . Biological compounds with antioxidant properties may contribute to the protection of cells against oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Alpha-Lipoic Acid Protects against Hepatic Ischemia-Reperfusion Injury in Rats

et al. 2007

View full text Add to dashboard Cite

Background and Aim: To evaluate the protective effect of alpha-lipoic acid in reducing oxidative damage after severe hepatic ischemia/reperfusion (IR) injury. Methods: Wistar albino rats were subjected to 45 min of hepatic ischemia, followed by 60 min reperfusion period. Lipoic acid (100 mg/kg i.p.) was administered 15 min prior to ischemia and immediately before reperfusion period. At the end of the reperfusion period aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) activity, and cytokine, TNF-α and IL-1β levels were determined in serum samples. Malondialdehyde (MDA), and glutathione (GSH) levels and myeloperoxidase (MPO) activity were determined in the liver tissue samples while formation of reactive oxygen species was monitored by using chemiluminescence (CL) technique with luminol and lucigenin probes. Tissues were also analyzed histologically. Results: Serum ALT, AST, and LDH activities and TNF-α and IL-1β levels were elevated in the I/R group, while this increase was significantly lower in the group of animals treated concomitantly with lipoic acid. Hepatic GSH levels, significantly depressed by I/R, were elevated back to control levels in lipoic acid-treated I/R group. Furthermore, increases in tissue luminol and lucigenin CL, MDA levels and MPO activity due to I/R injury were reduced back to control levels with lipoic acid treatment. Conclusion: Since lipoic acid administration alleviated the I/R-induced liver injury and improved the hepatic structure and function, it seems likely that lipoic acid with its antioxidant and oxidant-scavenging properties may be of potential therapeutic value in protecting the liver against oxidative injury due to ischemia-reperfusion.

show abstract

Time Course of Antioxidant Enzyme Activities in Liver Transplant Recipients

Cited by 36 publications

References 9 publications

Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children

Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children

Protective effect of Lysimachia christinae against acute alcohol-induced liver injury in mice

Alpha-Lipoic Acid Protects against Hepatic Ischemia-Reperfusion Injury in Rats

Contact Info

Product

Resources

About