Time course of diurnal rhythm disturbances in autonomic function of rats with myocardial infarction

Lee, Heow Won; Han, Tae Hee; Yi, Kang Jae; Choi, Mincheol; Lee, So Yeong; Ryu, Pan Dong

doi:10.1016/j.autneu.2013.06.007

Cited by 8 publications

(8 citation statements)

References 63 publications

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“…L/D differences in the LF/HIF ratio change from negative to positive values along with a decrease in SDANN, HR, LF/HIF ratio in the dark phase, and elevated plasma norepinephrine levels ( 66 ). These data suggest that the timing of the disturbance of diurnal rhythm in SDANN and the LF/HIF ratio are different from those in HR and in the plasma norepinephrine levels ( 67 ). In patients with HF, arterial underfilling caused by decreased cardiac output or peripheral arterial vasodilation activates the SNS, RAAS, and non-osmotic vasopressin release ( 68 ).…”

Section: The Autonomic Nervous System Regulates the Circadian Disruption In Hfmentioning

confidence: 97%

Improving Diuretic Response in Heart Failure by Implementing a Patient-Tailored Variability and Chronotherapy-Guided Algorithm

Kenig

Kolben

Asleh

et al. 2021

Front. Cardiovasc. Med.

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Heart failure is a major public health problem, which is associated with significant mortality, morbidity, and healthcare expenditures. A substantial amount of the morbidity is attributed to volume overload, for which loop diuretics are a mandatory treatment. However, the variability in response to diuretics and development of diuretic resistance adversely affect the clinical outcomes. Morevoer, there exists a marked intra- and inter-patient variability in response to diuretics that affects the clinical course and related adverse outcomes. In the present article, we review the mechanisms underlying the development of diuretic resistance. The role of the autonomic nervous system and chronobiology in the pathogenesis of congestive heart failure and response to therapy are also discussed. Establishing a novel model for overcoming diuretic resistance is presented based on a patient-tailored variability and chronotherapy-guided machine learning algorithm that comprises clinical, laboratory, and sensor-derived inputs, including inputs from pulmonary artery measurements. Inter- and intra-patient signatures of variabilities, alterations of biological clock, and autonomic nervous system responses are embedded into the algorithm; thus, it may enable a tailored dose regimen in a continuous manner that accommodates the highly dynamic complex system.

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Section: The Autonomic Nervous System Regulates the Circadian Disruption In Hfmentioning

confidence: 97%

Improving Diuretic Response in Heart Failure by Implementing a Patient-Tailored Variability and Chronotherapy-Guided Algorithm

Kenig

Kolben

Asleh

et al. 2021

Front. Cardiovasc. Med.

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“…In this study, we made a continuous observation of HRV and distributed density of vagal nerve fibers or sympathetic nerve fibers during a 10-week of period of STZ-induced diabetes. [4][5][6]. VLF represents factors such as thermo regulation, the renin-angiotensin system, and endothelial functioning [7].…”

Section: Introduction ▼mentioning

confidence: 99%

Analysis of Heart Rate Variability and Cardiac Autonomic Nerve Remodeling in Streptozotocin-induced Diabetic Rats

Jiang

et al. 2015

Exp Clin Endocrinol Diabetes

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“…Experimental studies (27,28) show that starting from the second week post-MI, the spectral variables of BP and heart rate were not different throughout the course of the disease. For example, Lee et al (29) evaluated autonomic variation in rats from 2–8 weeks after coronary ligation via electrocardiogram recording by telemetry. The authors found no change in spectral power over the observation period.…”

Section: Discussionmentioning

confidence: 99%

Time course of changes in heart rate and blood pressure variability in rats with myocardial infarction

Aires

Pimentel

Forechi

et al. 2017

Braz J Med Biol Res

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Our aim was to determine the time course of changes in autonomic balance in the acute (1 and 3 days), sub-acute (7 days) and chronic (28 days) phases of myocardial infarction (MI) in rats. Autonomic balance was assessed by temporal and spectral analyses of blood pressure variability (BPV) and heart rate variability (HRV). Pulsatile blood pressure (BP) recordings (30 min) were obtained in awake and unrestrained male Wistar rats (N = 77; 8-10 weeks old) with MI (coronary ligature) or sham operation (SO). Data are reported as means±SE. The high frequency (HF) component (n.u.) of HRV was significantly lower in MI-1- (P<0.01) and MI-3-day rats (P<0.05) than in their time-control groups (SO-1=68±4 vs MI-1=35.3±4.3; SO-3=71±5.8 vs MI-3=45.2±3.8), without differences thereafter (SO-7=69.2±4.8 vs MI-7=56±5.8; SO-28=73±4 vs MI-28=66±6.6). A sharp reduction (P<0.05) of BPV (mmHg2) was observed in the first week after MI (SO-1=8.55±0.80; SO-3=9.11±1.08; SO-7=7.92±1.10 vs MI-1=5.63±0.73; MI-3=5.93±0.30; MI-7=5.30±0.25). Normal BPV, however, was observed 4 weeks after MI (SO-28=8.60±0.66 vs MI-28=8.43±0.56 mmHg2; P>0.05). This reduction was mainly due to attenuation of the low frequency (LF) band of BPV in absolute and normalized units (SO-1=39.3±7%; SO-3=55±4.5%; SO-7=46.8±4.5%; SO-28=45.7±5%; MI-1=13±3.5%; MI-3=35±4.7%; MI-7=25±2.8%; MI-28=21.4±2.8%). The results suggest that the reduction in HRV was associated with decrease of the HF component of HRV suggesting recovery of the vagal control of heartbeats along the post-infarction healing period. The depression of BPV was more dependent on the attenuation of the LF component, which is linked to the baroreflex modulation of the autonomic balance.

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Time course of diurnal rhythm disturbances in autonomic function of rats with myocardial infarction

Cited by 8 publications

References 63 publications

Improving Diuretic Response in Heart Failure by Implementing a Patient-Tailored Variability and Chronotherapy-Guided Algorithm

Improving Diuretic Response in Heart Failure by Implementing a Patient-Tailored Variability and Chronotherapy-Guided Algorithm

Analysis of Heart Rate Variability and Cardiac Autonomic Nerve Remodeling in Streptozotocin-induced Diabetic Rats

Time course of changes in heart rate and blood pressure variability in rats with myocardial infarction

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