Time course of myocardial viability after acute myocardial infarction: An echocardiographic study

Knudsen, Alice; Darwish, A.Z.; Nørgaard, Aage; Gøtzsche, Ole; Thygesen, Kristian

doi:10.1016/s0002-8703(98)70342-4

Cited by 27 publications

(20 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the finding of perinecrotic viable tissue in patients who later experienced an in-stent occlusion was not consistent with the relationship between the lack of viability in the infarct area and the development of a restenosis suggested by Assmus et al (33). According to the usual time course of myocardial viability after AMI (38), a progressive reduction in the number of viable segments was observed at 6 and 12 mo, without any significant differences among the groups differently treated (Table 1).…”

Section: Discussionmentioning

confidence: 70%

The Role of PET with ¹³N-Ammonia and ¹⁸F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

et al. 2010

View full text Add to dashboard Cite

Over the last decade, the effects of stem cell therapy on cardiac repair after acute myocardial infarction (AMI) have been investigated with different imaging techniques. We evaluated a new imaging approach using 13 N-ammonia and 18 F-FDG PET for a combined analysis of cardiac perfusion, metabolism, and function in patients treated with intracoronary injection of endothelial progenitors or with conventional therapy for AMI. Methods: A total of 15 patients were randomly assigned to 3 groups based on different treatments (group A: bone marrow-derived stem cells; group B: peripheral blood-derived stem cells; group C: standard therapy alone). The number of scarred and viable segments, along with the infarct size and the extent of the viable area, were determined on a 9-segment 13 N-ammonia/ 18 F-FDG PET polar map. Myocardial blood flow (MBF) was calculated for each segment on the ammonia polar map, whereas a global evaluation of left ventricular function was obtained by estimating left ventricular ejection fraction (LVEF) and end-diastolic volume, both derived from electrocardiography-gated 18 F-FDG images. Both intragroup and intergroup comparative analyses of the mean values of each parameter were performed at baseline and 3, 6, and 12 mo after AMI. During follow-up, major cardiac events were also registered. Results: A significant decrease (P , 0.05) in the number of scarred segments and infarct size was observed in group A, along with an increase in MBF (P , 0.05) and a mild improvement in cardiac function. Lack of infarct size shrinkage in group B was associated with a marked impairment of MBF (P 5 0.01) and cardiac dysfunction. Ambiguous changes in infarct size, MBF, and LVEF were found in group C. No differences in number of viable segments or in extent of viable area were found among the groups. At clinical follow-up, no major cardiac events occurred in group A patients, whereas 2 patients of group B experienced in-stent occlusion and one patient of group C received a transplant for heart failure. Conclusion: Our data suggest that a single nuclear imaging technique accurately analyzes changes in myocardial perfusion and metabolism occurring after stem cell transplantation.

show abstract

Section: Discussionmentioning

confidence: 70%

The Role of PET with ¹³N-Ammonia and ¹⁸F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Each segment was graded according to the semiquantitative scoring system described by Knudsen and colleagues. 21 Views were acquired and analyzed upon CCU admission, and again 6 months later, by a single echocardiographer, using the software program of the echocardiography machine and blinded to the study protocol.…”

Section: Echocardiographic Evaluationmentioning

confidence: 99%

Intensive Statin Therapy in NSTE-ACS Patients Undergoing PCI: Clinical and Biochemical Effects

Shehata¹,

Fayez²,

Nassar³

2015

Texas Heart Institute Journal

View full text Add to dashboard Cite

Early initiation of statin therapy in acute coronary syndrome patients has a favorable prognostic impact because of its anti-inflammatory and antithrombotic properties. In this study, we explored the effect of atorvastatin-loading, followed by intensive atorvastatin therapy, on clinical and biochemical outcomes in non-ST-segment-elevation acute coronary syndrome patients who were scheduled for percutaneous coronary intervention. We prospectively enrolled 140 patients (mean age, 56 ± 9 years, 68% men). Once eligible, patients were randomly assigned to receive either a moderate 20-mg daily dose of atorvastatin (Group A) or a 160-mg loading dose followed by an intensified 80-mg daily dose (Group B). High-sensitivity C-reactive protein (hs-CRP) levels were recorded before and after intervention. Evaluation after 6 months included hs-CRP levels, left ventricular systolic function, and major adverse cardiac events. We found no significant difference between the 2 groups in regard to the interventional data. However, blood sampling after coronary intervention, and again 6 months later, revealed a significant decline in mean hs-CRP level among Group B patients (P <0.001). Moreover, patients in Group B manifested a higher left ventricular ejection fraction than did patients in Group A (P <0.05). After 6 months, we found no significant difference between groups in the incidence of major adverse cardiac events. We conclude that intensive atorvastatin therapy in non-ST-segment-elevation acute coronary syndrome patients is associated with lower hs-CRP levels and with higher left ventricular ejection fraction after 6 months, with no significant impact on adverse cardiac events.

show abstract

“…Individual segments were then sub-grouped based on the known vascular distribution into left anterior descending territory, left circumflex territory, right coronary artery territory, and overlap segments 7 . Regional wall motion was visually assessed for each segment individually, considering both endocardial excursion and systolic thickening, and each segment was graded according to the semiquantitative scoring system described by Knudsen et al 8 . Segments with poorly defined endocardial borders for 50% or more of their length were considered non-visualized and assigned a score of 0 9 .…”

Section: Baseline Echocardiographic Assessmentmentioning

confidence: 99%

“…All studies were subjected to quality-control checks and cor rections when necessary for camera non-uniformity, center-of -rotation offsets, patient motion, and "upward creep" 8 .…”

Section: Abdel-salam and Nammas Viability In Negative Dobutamine Echocamentioning

confidence: 99%

Preditores de viabilidade em pacientes com resposta negativa à ecocardiografia de estresse com dobutamina de baixa dose

Abdel-Salam

Nammas

2011

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

Time course of myocardial viability after acute myocardial infarction: An echocardiographic study

Cited by 27 publications

References 27 publications

The Role of PET with ¹³N-Ammonia and ¹⁸F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

The Role of PET with ¹³N-Ammonia and ¹⁸F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

Intensive Statin Therapy in NSTE-ACS Patients Undergoing PCI: Clinical and Biochemical Effects

Preditores de viabilidade em pacientes com resposta negativa à ecocardiografia de estresse com dobutamina de baixa dose

Contact Info

Product

Resources

About

Time course of myocardial viability after acute myocardial infarction: An echocardiographic study

Cited by 27 publications

References 27 publications

The Role of PET with 13N-Ammonia and 18F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

The Role of PET with 13N-Ammonia and 18F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

Intensive Statin Therapy in NSTE-ACS Patients Undergoing PCI: Clinical and Biochemical Effects

Preditores de viabilidade em pacientes com resposta negativa à ecocardiografia de estresse com dobutamina de baixa dose

Contact Info

Product

Resources

About

The Role of PET with ¹³N-Ammonia and ¹⁸F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

The Role of PET with ¹³N-Ammonia and ¹⁸F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection